Anti-Babesial Compounds from Berberis Vulgaris

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Bibliographische Detailangaben
Zeitschriftentitel:	Natural Product Communications
Personen und Körperschaften:	Elkhateeb, A., Yamada, K., Takahashi, K., Matsuura, H., Yamasaki, M., Maede, Y., Katakura, K., Nabeta, K.
In:	Natural Product Communications, 2, 2007, 2, S. 1934578X0700200
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	SAGE Publications
Schlagwörter:	Complementary and alternative medicine Plant Science Drug Discovery Pharmacology General Medicine

Details
Zusammenfassung:	<jats:p> Extracts of nine North African medicinal plants have been evaluated for their anti-babesial properties in vitro. The extracts of Berberis vulgaris and Rosa damascena showed more than 90% inhibition of the parasite growth at a test concentration of 100 μg/mL. In addition to berberine alkaloids, we isolated nine active ingredients from B. vulgaris: E-coniferyl alcohol, (-)-simulanol, p-hydroxybenzaldehyde, 3-hydroxy-4,5-dimethoxybenzoic acid, trans-ferulic acid, syringic acid, vanillic acid, cis-ferulic acid, and syringaresinol-β-D-glucoside. These compounds are all known, but are newly reported for B. vulgaris. Among them, trans-ferulic acid showed the lowest IC<jats:sub>50</jats:sub> value (7.33 μg/mL), not much above that of the standard drug, diminazene aceturate (0.60 μg/mL). </jats:p>
Umfang:	1934578X0700200
ISSN:	1934-578X 1555-9475
DOI:	10.1177/1934578x0700200213