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IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children
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| Zeitschriftentitel: | International Journal of Immunopathology and Pharmacology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | International Journal of Immunopathology and Pharmacology, 20, 2007, 3, S. 467-472 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Bodini, A. D'Orazio, C. Peroni, D.G. Corradi, M. Zerman, L. Folesani, G. Assael, B.M. Boner, A.L. Piacentini, G.L. Bodini, A. D'Orazio, C. Peroni, D.G. Corradi, M. Zerman, L. Folesani, G. Assael, B.M. Boner, A.L. Piacentini, G.L. |
|---|---|
| author |
Bodini, A. D'Orazio, C. Peroni, D.G. Corradi, M. Zerman, L. Folesani, G. Assael, B.M. Boner, A.L. Piacentini, G.L. |
| spellingShingle |
Bodini, A. D'Orazio, C. Peroni, D.G. Corradi, M. Zerman, L. Folesani, G. Assael, B.M. Boner, A.L. Piacentini, G.L. International Journal of Immunopathology and Pharmacology IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children Pharmacology Immunology Immunology and Allergy Pharmacology Immunology Immunology and Allergy |
| author_sort |
bodini, a. |
| spelling |
Bodini, A. D'Orazio, C. Peroni, D.G. Corradi, M. Zerman, L. Folesani, G. Assael, B.M. Boner, A.L. Piacentini, G.L. 2058-7384 2058-7384 SAGE Publications Pharmacology Immunology Immunology and Allergy Pharmacology Immunology Immunology and Allergy http://dx.doi.org/10.1177/039463200702000305 <jats:p> Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidification. The aim of our study is to investigate whether IL-8 and pH levels in EBC of cystic fibrosis (CF) children with respiratory exacerbations change after antibiotic treatment. Lung function, IL-8 and pH EBC values were measured in fifteen CF children (mean age 11 years) with acute exacerbation before (T0) and after two weeks (T1) of antibiotic treatment. IL-8 and pH values were compared by paired t-test. A p<0.05 was considered significant. IL-8 EBC levels decreased after antibiotic treatment (TO 0.36±0.03pg/ml vs T1 0.28±0.03pg/ml; p=0.03) and pH values increased (TO 7.3610.09 vs T1 7.61±0.08; p=0.04). Results suggest possible application of EBC as a non-invasive tool to monitor efficacy of antibiotic treatment in CF patients. </jats:p> IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children International Journal of Immunopathology and Pharmacology |
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| title |
IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| title_unstemmed |
IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| title_full |
IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| title_fullStr |
IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| title_full_unstemmed |
IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| title_short |
IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| title_sort |
il-8 and ph values in exhaled condensate after antibiotics in cystic fibrosis children |
| topic |
Pharmacology Immunology Immunology and Allergy Pharmacology Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1177/039463200702000305 |
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2007 |
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467-472 |
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<jats:p> Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidification. The aim of our study is to investigate whether IL-8 and pH levels in EBC of cystic fibrosis (CF) children with respiratory exacerbations change after antibiotic treatment. Lung function, IL-8 and pH EBC values were measured in fifteen CF children (mean age 11 years) with acute exacerbation before (T0) and after two weeks (T1) of antibiotic treatment. IL-8 and pH values were compared by paired t-test. A p<0.05 was considered significant. IL-8 EBC levels decreased after antibiotic treatment (TO 0.36±0.03pg/ml vs T1 0.28±0.03pg/ml; p=0.03) and pH values increased (TO 7.3610.09 vs T1 7.61±0.08; p=0.04). Results suggest possible application of EBC as a non-invasive tool to monitor efficacy of antibiotic treatment in CF patients. </jats:p> |
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| author | Bodini, A., D'Orazio, C., Peroni, D.G., Corradi, M., Zerman, L., Folesani, G., Assael, B.M., Boner, A.L., Piacentini, G.L. |
| author_facet | Bodini, A., D'Orazio, C., Peroni, D.G., Corradi, M., Zerman, L., Folesani, G., Assael, B.M., Boner, A.L., Piacentini, G.L., Bodini, A., D'Orazio, C., Peroni, D.G., Corradi, M., Zerman, L., Folesani, G., Assael, B.M., Boner, A.L., Piacentini, G.L. |
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| description | <jats:p> Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidification. The aim of our study is to investigate whether IL-8 and pH levels in EBC of cystic fibrosis (CF) children with respiratory exacerbations change after antibiotic treatment. Lung function, IL-8 and pH EBC values were measured in fifteen CF children (mean age 11 years) with acute exacerbation before (T0) and after two weeks (T1) of antibiotic treatment. IL-8 and pH values were compared by paired t-test. A p<0.05 was considered significant. IL-8 EBC levels decreased after antibiotic treatment (TO 0.36±0.03pg/ml vs T1 0.28±0.03pg/ml; p=0.03) and pH values increased (TO 7.3610.09 vs T1 7.61±0.08; p=0.04). Results suggest possible application of EBC as a non-invasive tool to monitor efficacy of antibiotic treatment in CF patients. </jats:p> |
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| spelling | Bodini, A. D'Orazio, C. Peroni, D.G. Corradi, M. Zerman, L. Folesani, G. Assael, B.M. Boner, A.L. Piacentini, G.L. 2058-7384 2058-7384 SAGE Publications Pharmacology Immunology Immunology and Allergy Pharmacology Immunology Immunology and Allergy http://dx.doi.org/10.1177/039463200702000305 <jats:p> Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidification. The aim of our study is to investigate whether IL-8 and pH levels in EBC of cystic fibrosis (CF) children with respiratory exacerbations change after antibiotic treatment. Lung function, IL-8 and pH EBC values were measured in fifteen CF children (mean age 11 years) with acute exacerbation before (T0) and after two weeks (T1) of antibiotic treatment. IL-8 and pH values were compared by paired t-test. A p<0.05 was considered significant. IL-8 EBC levels decreased after antibiotic treatment (TO 0.36±0.03pg/ml vs T1 0.28±0.03pg/ml; p=0.03) and pH values increased (TO 7.3610.09 vs T1 7.61±0.08; p=0.04). Results suggest possible application of EBC as a non-invasive tool to monitor efficacy of antibiotic treatment in CF patients. </jats:p> IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children International Journal of Immunopathology and Pharmacology |
| spellingShingle | Bodini, A., D'Orazio, C., Peroni, D.G., Corradi, M., Zerman, L., Folesani, G., Assael, B.M., Boner, A.L., Piacentini, G.L., International Journal of Immunopathology and Pharmacology, IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children, Pharmacology, Immunology, Immunology and Allergy, Pharmacology, Immunology, Immunology and Allergy |
| title | IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| title_full | IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| title_fullStr | IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| title_full_unstemmed | IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| title_short | IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| title_sort | il-8 and ph values in exhaled condensate after antibiotics in cystic fibrosis children |
| title_unstemmed | IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children |
| topic | Pharmacology, Immunology, Immunology and Allergy, Pharmacology, Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1177/039463200702000305 |