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IL-8 and pH Values in Exhaled Condensate after Antibiotics in Cystic Fibrosis Children
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| Zeitschriftentitel: | International Journal of Immunopathology and Pharmacology |
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| Personen und Körperschaften: | , , , , , , , , |
| In: | International Journal of Immunopathology and Pharmacology, 20, 2007, 3, S. 467-472 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| Zusammenfassung: | <jats:p> Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidification. The aim of our study is to investigate whether IL-8 and pH levels in EBC of cystic fibrosis (CF) children with respiratory exacerbations change after antibiotic treatment. Lung function, IL-8 and pH EBC values were measured in fifteen CF children (mean age 11 years) with acute exacerbation before (T0) and after two weeks (T1) of antibiotic treatment. IL-8 and pH values were compared by paired t-test. A p<0.05 was considered significant. IL-8 EBC levels decreased after antibiotic treatment (TO 0.36±0.03pg/ml vs T1 0.28±0.03pg/ml; p=0.03) and pH values increased (TO 7.3610.09 vs T1 7.61±0.08; p=0.04). Results suggest possible application of EBC as a non-invasive tool to monitor efficacy of antibiotic treatment in CF patients. </jats:p> |
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| Umfang: | 467-472 |
| ISSN: |
2058-7384
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| DOI: | 10.1177/039463200702000305 |