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Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells
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Zeitschriftentitel: | Circulation Research |
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Personen und Körperschaften: | , , , , , , , , |
In: | Circulation Research, 113, 2013, 7, S. 856-862 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
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Schlagwörter: |
author_facet |
Ohtani, Kisho Zhao, Cong Dobreva, Gergana Manavski, Yosif Kluge, Britta Braun, Thomas Rieger, Michael A. Zeiher, Andreas M. Dimmeler, Stefanie Ohtani, Kisho Zhao, Cong Dobreva, Gergana Manavski, Yosif Kluge, Britta Braun, Thomas Rieger, Michael A. Zeiher, Andreas M. Dimmeler, Stefanie |
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author |
Ohtani, Kisho Zhao, Cong Dobreva, Gergana Manavski, Yosif Kluge, Britta Braun, Thomas Rieger, Michael A. Zeiher, Andreas M. Dimmeler, Stefanie |
spellingShingle |
Ohtani, Kisho Zhao, Cong Dobreva, Gergana Manavski, Yosif Kluge, Britta Braun, Thomas Rieger, Michael A. Zeiher, Andreas M. Dimmeler, Stefanie Circulation Research Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells Cardiology and Cardiovascular Medicine Physiology |
author_sort |
ohtani, kisho |
spelling |
Ohtani, Kisho Zhao, Cong Dobreva, Gergana Manavski, Yosif Kluge, Britta Braun, Thomas Rieger, Michael A. Zeiher, Andreas M. Dimmeler, Stefanie 0009-7330 1524-4571 Ovid Technologies (Wolters Kluwer Health) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1161/circresaha.113.302035 <jats:sec> <jats:title> <jats:underline>Rationale:</jats:underline> </jats:title> <jats:p>The developmental role of the H3K27 demethylases Jmjd3, especially its epigenetic regulation at target genes in response to upstream developmental signaling, is unclear.</jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Objective:</jats:underline> </jats:title> <jats:p>To determine the role of Jmjd3 during mesoderm and cardiovascular lineage commitment.</jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Methods and Results:</jats:underline> </jats:title> <jats:p> Ablation of Jmjd3 in mouse embryonic stem cells does not affect the maintenance of pluripotency and self-renewal but compromised mesoderm and subsequent endothelial and cardiac differentiation. Jmjd3 reduces H3K27me3 marks at the <jats:italic>Brachyury</jats:italic> promoter and facilitates the recruitment of β-catenin, which is critical for Wnt signal–induced mesoderm differentiation. </jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Conclusions:</jats:underline> </jats:title> <jats:p>These data demonstrate that Jmjd3 is required for mesoderm differentiation and cardiovascular lineage commitment.</jats:p> </jats:sec> Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells Circulation Research |
doi_str_mv |
10.1161/circresaha.113.302035 |
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Online Free |
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Medizin Biologie |
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ElectronicArticle |
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Ovid Technologies (Wolters Kluwer Health), 2013 |
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Ovid Technologies (Wolters Kluwer Health), 2013 |
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0009-7330 1524-4571 |
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2013 |
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Ovid Technologies (Wolters Kluwer Health) |
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Circulation Research |
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49 |
title |
Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
title_unstemmed |
Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
title_full |
Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
title_fullStr |
Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
title_full_unstemmed |
Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
title_short |
Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
title_sort |
jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells |
topic |
Cardiology and Cardiovascular Medicine Physiology |
url |
http://dx.doi.org/10.1161/circresaha.113.302035 |
publishDate |
2013 |
physical |
856-862 |
description |
<jats:sec>
<jats:title>
<jats:underline>Rationale:</jats:underline>
</jats:title>
<jats:p>The developmental role of the H3K27 demethylases Jmjd3, especially its epigenetic regulation at target genes in response to upstream developmental signaling, is unclear.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>
<jats:underline>Objective:</jats:underline>
</jats:title>
<jats:p>To determine the role of Jmjd3 during mesoderm and cardiovascular lineage commitment.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>
<jats:underline>Methods and Results:</jats:underline>
</jats:title>
<jats:p>
Ablation of Jmjd3 in mouse embryonic stem cells does not affect the maintenance of pluripotency and self-renewal but compromised mesoderm and subsequent endothelial and cardiac differentiation. Jmjd3 reduces H3K27me3 marks at the
<jats:italic>Brachyury</jats:italic>
promoter and facilitates the recruitment of β-catenin, which is critical for Wnt signal–induced mesoderm differentiation.
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>
<jats:underline>Conclusions:</jats:underline>
</jats:title>
<jats:p>These data demonstrate that Jmjd3 is required for mesoderm differentiation and cardiovascular lineage commitment.</jats:p>
</jats:sec> |
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author | Ohtani, Kisho, Zhao, Cong, Dobreva, Gergana, Manavski, Yosif, Kluge, Britta, Braun, Thomas, Rieger, Michael A., Zeiher, Andreas M., Dimmeler, Stefanie |
author_facet | Ohtani, Kisho, Zhao, Cong, Dobreva, Gergana, Manavski, Yosif, Kluge, Britta, Braun, Thomas, Rieger, Michael A., Zeiher, Andreas M., Dimmeler, Stefanie, Ohtani, Kisho, Zhao, Cong, Dobreva, Gergana, Manavski, Yosif, Kluge, Britta, Braun, Thomas, Rieger, Michael A., Zeiher, Andreas M., Dimmeler, Stefanie |
author_sort | ohtani, kisho |
container_issue | 7 |
container_start_page | 856 |
container_title | Circulation Research |
container_volume | 113 |
description | <jats:sec> <jats:title> <jats:underline>Rationale:</jats:underline> </jats:title> <jats:p>The developmental role of the H3K27 demethylases Jmjd3, especially its epigenetic regulation at target genes in response to upstream developmental signaling, is unclear.</jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Objective:</jats:underline> </jats:title> <jats:p>To determine the role of Jmjd3 during mesoderm and cardiovascular lineage commitment.</jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Methods and Results:</jats:underline> </jats:title> <jats:p> Ablation of Jmjd3 in mouse embryonic stem cells does not affect the maintenance of pluripotency and self-renewal but compromised mesoderm and subsequent endothelial and cardiac differentiation. Jmjd3 reduces H3K27me3 marks at the <jats:italic>Brachyury</jats:italic> promoter and facilitates the recruitment of β-catenin, which is critical for Wnt signal–induced mesoderm differentiation. </jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Conclusions:</jats:underline> </jats:title> <jats:p>These data demonstrate that Jmjd3 is required for mesoderm differentiation and cardiovascular lineage commitment.</jats:p> </jats:sec> |
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spelling | Ohtani, Kisho Zhao, Cong Dobreva, Gergana Manavski, Yosif Kluge, Britta Braun, Thomas Rieger, Michael A. Zeiher, Andreas M. Dimmeler, Stefanie 0009-7330 1524-4571 Ovid Technologies (Wolters Kluwer Health) Cardiology and Cardiovascular Medicine Physiology http://dx.doi.org/10.1161/circresaha.113.302035 <jats:sec> <jats:title> <jats:underline>Rationale:</jats:underline> </jats:title> <jats:p>The developmental role of the H3K27 demethylases Jmjd3, especially its epigenetic regulation at target genes in response to upstream developmental signaling, is unclear.</jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Objective:</jats:underline> </jats:title> <jats:p>To determine the role of Jmjd3 during mesoderm and cardiovascular lineage commitment.</jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Methods and Results:</jats:underline> </jats:title> <jats:p> Ablation of Jmjd3 in mouse embryonic stem cells does not affect the maintenance of pluripotency and self-renewal but compromised mesoderm and subsequent endothelial and cardiac differentiation. Jmjd3 reduces H3K27me3 marks at the <jats:italic>Brachyury</jats:italic> promoter and facilitates the recruitment of β-catenin, which is critical for Wnt signal–induced mesoderm differentiation. </jats:p> </jats:sec> <jats:sec> <jats:title> <jats:underline>Conclusions:</jats:underline> </jats:title> <jats:p>These data demonstrate that Jmjd3 is required for mesoderm differentiation and cardiovascular lineage commitment.</jats:p> </jats:sec> Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells Circulation Research |
spellingShingle | Ohtani, Kisho, Zhao, Cong, Dobreva, Gergana, Manavski, Yosif, Kluge, Britta, Braun, Thomas, Rieger, Michael A., Zeiher, Andreas M., Dimmeler, Stefanie, Circulation Research, Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells, Cardiology and Cardiovascular Medicine, Physiology |
title | Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
title_full | Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
title_fullStr | Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
title_full_unstemmed | Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
title_short | Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
title_sort | jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells |
title_unstemmed | Jmjd3 Controls Mesodermal and Cardiovascular Differentiation of Embryonic Stem Cells |
topic | Cardiology and Cardiovascular Medicine, Physiology |
url | http://dx.doi.org/10.1161/circresaha.113.302035 |