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Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging
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| Zeitschriftentitel: | Stroke |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Stroke, 35, 2004, 2, S. 566-571 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Gerriets, T. Stolz, E. Walberer, M. Müller, C. Kluge, A. Bachmann, A. Fisher, M. Kaps, M. Bachmann, G. Gerriets, T. Stolz, E. Walberer, M. Müller, C. Kluge, A. Bachmann, A. Fisher, M. Kaps, M. Bachmann, G. |
|---|---|
| author |
Gerriets, T. Stolz, E. Walberer, M. Müller, C. Kluge, A. Bachmann, A. Fisher, M. Kaps, M. Bachmann, G. |
| spellingShingle |
Gerriets, T. Stolz, E. Walberer, M. Müller, C. Kluge, A. Bachmann, A. Fisher, M. Kaps, M. Bachmann, G. Stroke Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| author_sort |
gerriets, t. |
| spelling |
Gerriets, T. Stolz, E. Walberer, M. Müller, C. Kluge, A. Bachmann, A. Fisher, M. Kaps, M. Bachmann, G. 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/01.str.0000113692.38574.57 <jats:p> <jats:bold> <jats:italic>Background and Purpose—</jats:italic> </jats:bold> Brain edema is a life-threatening consequence of stroke and leads to an extension of the affected tissue. The space-occupying effect due to brain edema can be quantified in rat stroke models with the use of MRI. The present study was performed to test 2 hypotheses: (1) Can quantification of the space-occupying effect due to brain edema serve as a noninvasive measure for brain water content? (2) Does morphometric assessment of brain swelling allow determination of true infarct size on MRI after correction for the space-occupying effect of edema? </jats:p> <jats:p> <jats:bold> <jats:italic>Methods—</jats:italic> </jats:bold> Thirty rats were subjected to permanent suture middle cerebral artery occlusion. MRI was performed after 6 or 24 hours, and hemispheric swelling was assessed morphometrically. Interobserver and intraobserver agreements were determined for MRI measurements. In study I, the space-occupying effect due to brain edema was correlated with the absolute brain water content by the wet/dry method. In study II, lesion volumes corrected and uncorrected for edema were calculated on MRI and on TTC staining and compared. </jats:p> <jats:p> <jats:bold> <jats:italic>Results—</jats:italic> </jats:bold> Interobserver and intraobserver agreements for MRI measurements were excellent ( <jats:italic>r</jats:italic> ≥0.97). Brain water content and hemispheric swelling correlated well after 6 and 24 hours ( <jats:italic>r</jats:italic> ≥0.95). Corrected lesion volumes correlated with <jats:italic>r</jats:italic> =0.78 between TTC staining and MRI. Without edema correction, lesion volumes were overestimated by 20.3% after 6 hours and by 29.6% after 24 hours of ischemia. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> Morphometric assessment of hemispheric swelling on MRI can determine the increase in absolute brain water content noninvasively and can also provide ischemic lesion volumes corrected for brain edema. </jats:p> Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging Stroke |
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Ovid Technologies (Wolters Kluwer Health), 2004 |
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0039-2499 1524-4628 |
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Stroke |
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49 |
| title |
Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| title_unstemmed |
Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| title_full |
Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| title_fullStr |
Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| title_full_unstemmed |
Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| title_short |
Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| title_sort |
noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging |
| topic |
Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) |
| url |
http://dx.doi.org/10.1161/01.str.0000113692.38574.57 |
| publishDate |
2004 |
| physical |
566-571 |
| description |
<jats:p>
<jats:bold>
<jats:italic>Background and Purpose—</jats:italic>
</jats:bold>
Brain edema is a life-threatening consequence of stroke and leads to an extension of the affected tissue. The space-occupying effect due to brain edema can be quantified in rat stroke models with the use of MRI. The present study was performed to test 2 hypotheses: (1) Can quantification of the space-occupying effect due to brain edema serve as a noninvasive measure for brain water content? (2) Does morphometric assessment of brain swelling allow determination of true infarct size on MRI after correction for the space-occupying effect of edema?
</jats:p>
<jats:p>
<jats:bold>
<jats:italic>Methods—</jats:italic>
</jats:bold>
Thirty rats were subjected to permanent suture middle cerebral artery occlusion. MRI was performed after 6 or 24 hours, and hemispheric swelling was assessed morphometrically. Interobserver and intraobserver agreements were determined for MRI measurements. In study I, the space-occupying effect due to brain edema was correlated with the absolute brain water content by the wet/dry method. In study II, lesion volumes corrected and uncorrected for edema were calculated on MRI and on TTC staining and compared.
</jats:p>
<jats:p>
<jats:bold>
<jats:italic>Results—</jats:italic>
</jats:bold>
Interobserver and intraobserver agreements for MRI measurements were excellent (
<jats:italic>r</jats:italic>
≥0.97). Brain water content and hemispheric swelling correlated well after 6 and 24 hours (
<jats:italic>r</jats:italic>
≥0.95). Corrected lesion volumes correlated with
<jats:italic>r</jats:italic>
=0.78 between TTC staining and MRI. Without edema correction, lesion volumes were overestimated by 20.3% after 6 hours and by 29.6% after 24 hours of ischemia.
</jats:p>
<jats:p>
<jats:bold>
<jats:italic>Conclusions—</jats:italic>
</jats:bold>
Morphometric assessment of hemispheric swelling on MRI can determine the increase in absolute brain water content noninvasively and can also provide ischemic lesion volumes corrected for brain edema.
</jats:p> |
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| author | Gerriets, T., Stolz, E., Walberer, M., Müller, C., Kluge, A., Bachmann, A., Fisher, M., Kaps, M., Bachmann, G. |
| author_facet | Gerriets, T., Stolz, E., Walberer, M., Müller, C., Kluge, A., Bachmann, A., Fisher, M., Kaps, M., Bachmann, G., Gerriets, T., Stolz, E., Walberer, M., Müller, C., Kluge, A., Bachmann, A., Fisher, M., Kaps, M., Bachmann, G. |
| author_sort | gerriets, t. |
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| description | <jats:p> <jats:bold> <jats:italic>Background and Purpose—</jats:italic> </jats:bold> Brain edema is a life-threatening consequence of stroke and leads to an extension of the affected tissue. The space-occupying effect due to brain edema can be quantified in rat stroke models with the use of MRI. The present study was performed to test 2 hypotheses: (1) Can quantification of the space-occupying effect due to brain edema serve as a noninvasive measure for brain water content? (2) Does morphometric assessment of brain swelling allow determination of true infarct size on MRI after correction for the space-occupying effect of edema? </jats:p> <jats:p> <jats:bold> <jats:italic>Methods—</jats:italic> </jats:bold> Thirty rats were subjected to permanent suture middle cerebral artery occlusion. MRI was performed after 6 or 24 hours, and hemispheric swelling was assessed morphometrically. Interobserver and intraobserver agreements were determined for MRI measurements. In study I, the space-occupying effect due to brain edema was correlated with the absolute brain water content by the wet/dry method. In study II, lesion volumes corrected and uncorrected for edema were calculated on MRI and on TTC staining and compared. </jats:p> <jats:p> <jats:bold> <jats:italic>Results—</jats:italic> </jats:bold> Interobserver and intraobserver agreements for MRI measurements were excellent ( <jats:italic>r</jats:italic> ≥0.97). Brain water content and hemispheric swelling correlated well after 6 and 24 hours ( <jats:italic>r</jats:italic> ≥0.95). Corrected lesion volumes correlated with <jats:italic>r</jats:italic> =0.78 between TTC staining and MRI. Without edema correction, lesion volumes were overestimated by 20.3% after 6 hours and by 29.6% after 24 hours of ischemia. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> Morphometric assessment of hemispheric swelling on MRI can determine the increase in absolute brain water content noninvasively and can also provide ischemic lesion volumes corrected for brain edema. </jats:p> |
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| imprint_str_mv | Ovid Technologies (Wolters Kluwer Health), 2004 |
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| spelling | Gerriets, T. Stolz, E. Walberer, M. Müller, C. Kluge, A. Bachmann, A. Fisher, M. Kaps, M. Bachmann, G. 0039-2499 1524-4628 Ovid Technologies (Wolters Kluwer Health) Advanced and Specialized Nursing Cardiology and Cardiovascular Medicine Neurology (clinical) http://dx.doi.org/10.1161/01.str.0000113692.38574.57 <jats:p> <jats:bold> <jats:italic>Background and Purpose—</jats:italic> </jats:bold> Brain edema is a life-threatening consequence of stroke and leads to an extension of the affected tissue. The space-occupying effect due to brain edema can be quantified in rat stroke models with the use of MRI. The present study was performed to test 2 hypotheses: (1) Can quantification of the space-occupying effect due to brain edema serve as a noninvasive measure for brain water content? (2) Does morphometric assessment of brain swelling allow determination of true infarct size on MRI after correction for the space-occupying effect of edema? </jats:p> <jats:p> <jats:bold> <jats:italic>Methods—</jats:italic> </jats:bold> Thirty rats were subjected to permanent suture middle cerebral artery occlusion. MRI was performed after 6 or 24 hours, and hemispheric swelling was assessed morphometrically. Interobserver and intraobserver agreements were determined for MRI measurements. In study I, the space-occupying effect due to brain edema was correlated with the absolute brain water content by the wet/dry method. In study II, lesion volumes corrected and uncorrected for edema were calculated on MRI and on TTC staining and compared. </jats:p> <jats:p> <jats:bold> <jats:italic>Results—</jats:italic> </jats:bold> Interobserver and intraobserver agreements for MRI measurements were excellent ( <jats:italic>r</jats:italic> ≥0.97). Brain water content and hemispheric swelling correlated well after 6 and 24 hours ( <jats:italic>r</jats:italic> ≥0.95). Corrected lesion volumes correlated with <jats:italic>r</jats:italic> =0.78 between TTC staining and MRI. Without edema correction, lesion volumes were overestimated by 20.3% after 6 hours and by 29.6% after 24 hours of ischemia. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> Morphometric assessment of hemispheric swelling on MRI can determine the increase in absolute brain water content noninvasively and can also provide ischemic lesion volumes corrected for brain edema. </jats:p> Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging Stroke |
| spellingShingle | Gerriets, T., Stolz, E., Walberer, M., Müller, C., Kluge, A., Bachmann, A., Fisher, M., Kaps, M., Bachmann, G., Stroke, Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging, Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| title | Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| title_full | Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| title_fullStr | Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| title_full_unstemmed | Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| title_short | Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| title_sort | noninvasive quantification of brain edema and the space-occupying effect in rat stroke models using magnetic resonance imaging |
| title_unstemmed | Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging |
| topic | Advanced and Specialized Nursing, Cardiology and Cardiovascular Medicine, Neurology (clinical) |
| url | http://dx.doi.org/10.1161/01.str.0000113692.38574.57 |