Eintrag weiter verarbeiten
Noninvasive Quantification of Brain Edema and the Space-Occupying Effect in Rat Stroke Models Using Magnetic Resonance Imaging
Gespeichert in:
| Zeitschriftentitel: | Stroke |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Stroke, 35, 2004, 2, S. 566-571 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| Zusammenfassung: | <jats:p> <jats:bold> <jats:italic>Background and Purpose—</jats:italic> </jats:bold> Brain edema is a life-threatening consequence of stroke and leads to an extension of the affected tissue. The space-occupying effect due to brain edema can be quantified in rat stroke models with the use of MRI. The present study was performed to test 2 hypotheses: (1) Can quantification of the space-occupying effect due to brain edema serve as a noninvasive measure for brain water content? (2) Does morphometric assessment of brain swelling allow determination of true infarct size on MRI after correction for the space-occupying effect of edema? </jats:p> <jats:p> <jats:bold> <jats:italic>Methods—</jats:italic> </jats:bold> Thirty rats were subjected to permanent suture middle cerebral artery occlusion. MRI was performed after 6 or 24 hours, and hemispheric swelling was assessed morphometrically. Interobserver and intraobserver agreements were determined for MRI measurements. In study I, the space-occupying effect due to brain edema was correlated with the absolute brain water content by the wet/dry method. In study II, lesion volumes corrected and uncorrected for edema were calculated on MRI and on TTC staining and compared. </jats:p> <jats:p> <jats:bold> <jats:italic>Results—</jats:italic> </jats:bold> Interobserver and intraobserver agreements for MRI measurements were excellent ( <jats:italic>r</jats:italic> ≥0.97). Brain water content and hemispheric swelling correlated well after 6 and 24 hours ( <jats:italic>r</jats:italic> ≥0.95). Corrected lesion volumes correlated with <jats:italic>r</jats:italic> =0.78 between TTC staining and MRI. Without edema correction, lesion volumes were overestimated by 20.3% after 6 hours and by 29.6% after 24 hours of ischemia. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> Morphometric assessment of hemispheric swelling on MRI can determine the increase in absolute brain water content noninvasively and can also provide ischemic lesion volumes corrected for brain edema. </jats:p> |
|---|---|
| Umfang: | 566-571 |
| ISSN: |
0039-2499
1524-4628 |
| DOI: | 10.1161/01.str.0000113692.38574.57 |