ChIP-chip Comes of Age for Genome-wide Functional Analysis

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Bibliographische Detailangaben
Zeitschriftentitel:	Cancer Research
Personen und Körperschaften:	Wu, Jiejun, Smith, Laura T., Plass, Christoph, Huang, Tim H-M.
In:	Cancer Research, 66, 2006, 14, S. 6899-6902
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Association for Cancer Research (AACR)
Schlagwörter:	Cancer Research Oncology

Details
Zusammenfassung:	<jats:title>Abstract</jats:title> <jats:p>In the post-genome era, attention has focused on the functions of genome sequences and how they are regulated. The emerging epigenomic changes and the interactions between cis-acting elements and protein factors may play a central role in gene regulation. To understand the crosstalk between DNA and protein on a genome-wide scale, one emerging technique, called ChIP-chip, takes the strategy of combining chromatin immunoprecipitation with microarray. This new high-throughput strategy helps screen the targets of critical transcription factors and profile the genome-wide distribution of histone modifications, which will enable the feasibility of conducting a large-scale study, such as the Human Epigenome Project. (Cancer Res 2006; 66(14): 6899-902)</jats:p>
Umfang:	6899-6902
ISSN:	0008-5472 1538-7445
DOI:	10.1158/0008-5472.can-06-0276