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Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae
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| Zeitschriftentitel: | Allergy |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Allergy, 57, 2002, 8, S. 729-731 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Jeong, K. Y. Lee, I.‐Y. Ree, H.‐I. Hong, C.‐S. Yong, T.‐S. Jeong, K. Y. Lee, I.‐Y. Ree, H.‐I. Hong, C.‐S. Yong, T.‐S. |
|---|---|
| author |
Jeong, K. Y. Lee, I.‐Y. Ree, H.‐I. Hong, C.‐S. Yong, T.‐S. |
| spellingShingle |
Jeong, K. Y. Lee, I.‐Y. Ree, H.‐I. Hong, C.‐S. Yong, T.‐S. Allergy Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae Immunology Immunology and Allergy |
| author_sort |
jeong, k. y. |
| spelling |
Jeong, K. Y. Lee, I.‐Y. Ree, H.‐I. Hong, C.‐S. Yong, T.‐S. 0105-4538 1398-9995 Wiley Immunology Immunology and Allergy http://dx.doi.org/10.1034/j.1398-9995.2002.23623.x <jats:p> <jats:bold>Background: </jats:bold> House dust mite derived materials are known to be the most potent agent inducing allergic diseases. Localization of Der f 2 was attempted to specify the sites and concentrations of Der f 2 within the mite, which may indicate the importance of secreted materials and nonexcreted body components as allergen sources.</jats:p><jats:p> <jats:bold>Methods: </jats:bold> Serial cryostat sections of embedded live mites and the fecal pellets, collected by brush, were immunoprobed using monoclonal antibody (mAb) 2F38 raised against recombinant (r) Der f 2.</jats:p><jats:p> <jats:bold>Results: </jats:bold> Highest concentrations were found in the anterior midgut, implying that this is the site of Der f 2 synthesis and secretion. Digestive material and defecated fecal pellets were also labeled with mAb.</jats:p><jats:p> <jats:bold>Conclusions: </jats:bold> Our results show that the major allergen, Der f 2, found in the house dust mite <jats:italic>D. farinae</jats:italic> is derived from the digestive tract, and is concentrated in the feces.</jats:p> Localization of Der f 2 in the gut and fecal pellets of <i>Dermatophagoides farinae</i> Allergy |
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10.1034/j.1398-9995.2002.23623.x |
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| title |
Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| title_unstemmed |
Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| title_full |
Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| title_fullStr |
Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| title_full_unstemmed |
Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| title_short |
Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| title_sort |
localization of der f 2 in the gut and fecal pellets of <i>dermatophagoides farinae</i> |
| topic |
Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1034/j.1398-9995.2002.23623.x |
| publishDate |
2002 |
| physical |
729-731 |
| description |
<jats:p> <jats:bold>Background: </jats:bold> House dust mite derived materials are known to be the most potent agent inducing allergic diseases. Localization of Der f 2 was attempted to specify the sites and concentrations of Der f 2 within the mite, which may indicate the importance of secreted materials and nonexcreted body components as allergen sources.</jats:p><jats:p> <jats:bold>Methods: </jats:bold> Serial cryostat sections of embedded live mites and the fecal pellets, collected by brush, were immunoprobed using monoclonal antibody (mAb) 2F38 raised against recombinant (r) Der f 2.</jats:p><jats:p> <jats:bold>Results: </jats:bold> Highest concentrations were found in the anterior midgut, implying that this is the site of Der f 2 synthesis and secretion. Digestive material and defecated fecal pellets were also labeled with mAb.</jats:p><jats:p> <jats:bold>Conclusions: </jats:bold>
Our results show that the major allergen, Der f 2, found in the house dust mite
<jats:italic>D. farinae</jats:italic> is derived from the digestive tract, and is concentrated in the feces.</jats:p> |
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| author | Jeong, K. Y., Lee, I.‐Y., Ree, H.‐I., Hong, C.‐S., Yong, T.‐S. |
| author_facet | Jeong, K. Y., Lee, I.‐Y., Ree, H.‐I., Hong, C.‐S., Yong, T.‐S., Jeong, K. Y., Lee, I.‐Y., Ree, H.‐I., Hong, C.‐S., Yong, T.‐S. |
| author_sort | jeong, k. y. |
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| description | <jats:p> <jats:bold>Background: </jats:bold> House dust mite derived materials are known to be the most potent agent inducing allergic diseases. Localization of Der f 2 was attempted to specify the sites and concentrations of Der f 2 within the mite, which may indicate the importance of secreted materials and nonexcreted body components as allergen sources.</jats:p><jats:p> <jats:bold>Methods: </jats:bold> Serial cryostat sections of embedded live mites and the fecal pellets, collected by brush, were immunoprobed using monoclonal antibody (mAb) 2F38 raised against recombinant (r) Der f 2.</jats:p><jats:p> <jats:bold>Results: </jats:bold> Highest concentrations were found in the anterior midgut, implying that this is the site of Der f 2 synthesis and secretion. Digestive material and defecated fecal pellets were also labeled with mAb.</jats:p><jats:p> <jats:bold>Conclusions: </jats:bold> Our results show that the major allergen, Der f 2, found in the house dust mite <jats:italic>D. farinae</jats:italic> is derived from the digestive tract, and is concentrated in the feces.</jats:p> |
| doi_str_mv | 10.1034/j.1398-9995.2002.23623.x |
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| imprint | Wiley, 2002 |
| imprint_str_mv | Wiley, 2002 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 0105-4538, 1398-9995 |
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| spelling | Jeong, K. Y. Lee, I.‐Y. Ree, H.‐I. Hong, C.‐S. Yong, T.‐S. 0105-4538 1398-9995 Wiley Immunology Immunology and Allergy http://dx.doi.org/10.1034/j.1398-9995.2002.23623.x <jats:p> <jats:bold>Background: </jats:bold> House dust mite derived materials are known to be the most potent agent inducing allergic diseases. Localization of Der f 2 was attempted to specify the sites and concentrations of Der f 2 within the mite, which may indicate the importance of secreted materials and nonexcreted body components as allergen sources.</jats:p><jats:p> <jats:bold>Methods: </jats:bold> Serial cryostat sections of embedded live mites and the fecal pellets, collected by brush, were immunoprobed using monoclonal antibody (mAb) 2F38 raised against recombinant (r) Der f 2.</jats:p><jats:p> <jats:bold>Results: </jats:bold> Highest concentrations were found in the anterior midgut, implying that this is the site of Der f 2 synthesis and secretion. Digestive material and defecated fecal pellets were also labeled with mAb.</jats:p><jats:p> <jats:bold>Conclusions: </jats:bold> Our results show that the major allergen, Der f 2, found in the house dust mite <jats:italic>D. farinae</jats:italic> is derived from the digestive tract, and is concentrated in the feces.</jats:p> Localization of Der f 2 in the gut and fecal pellets of <i>Dermatophagoides farinae</i> Allergy |
| spellingShingle | Jeong, K. Y., Lee, I.‐Y., Ree, H.‐I., Hong, C.‐S., Yong, T.‐S., Allergy, Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae, Immunology, Immunology and Allergy |
| title | Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| title_full | Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| title_fullStr | Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| title_full_unstemmed | Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| title_short | Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| title_sort | localization of der f 2 in the gut and fecal pellets of <i>dermatophagoides farinae</i> |
| title_unstemmed | Localization of Der f 2 in the gut and fecal pellets of Dermatophagoides farinae |
| topic | Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1034/j.1398-9995.2002.23623.x |