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Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study
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| Zeitschriftentitel: | Epidemiology and Infection |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Epidemiology and Infection, 146, 2018, 15, S. 1891-1895 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge University Press (CUP)
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| Schlagwörter: |
| author_facet |
Zhou, N. Zhang, X. Y. Li, Y. X. Wang, L. Wang, L. L. Cong, W. Zhou, N. Zhang, X. Y. Li, Y. X. Wang, L. Wang, L. L. Cong, W. |
|---|---|
| author |
Zhou, N. Zhang, X. Y. Li, Y. X. Wang, L. Wang, L. L. Cong, W. |
| spellingShingle |
Zhou, N. Zhang, X. Y. Li, Y. X. Wang, L. Wang, L. L. Cong, W. Epidemiology and Infection Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study Infectious Diseases Epidemiology |
| author_sort |
zhou, n. |
| spelling |
Zhou, N. Zhang, X. Y. Li, Y. X. Wang, L. Wang, L. L. Cong, W. 0950-2688 1469-4409 Cambridge University Press (CUP) Infectious Diseases Epidemiology http://dx.doi.org/10.1017/s0950268818001978 <jats:title>Abstract</jats:title><jats:p>Over the recent years, potential associations between <jats:italic>Toxoplasma gondii</jats:italic> (<jats:italic>T. gondii</jats:italic>) infection and cancer risk have attracted a lot of attention. Nevertheless, the association between <jats:italic>T. gondii</jats:italic> infection and oral cancer remains relatively unexplored. We performed a case–control study of 861 oral cancer patients and 861 control subjects from eastern China with the aim to detect antibodies to <jats:italic>T. gondii</jats:italic> by enzyme-linked immunosorbent assay (ELISA) in these patients. The results showed that oral cancer patients (21.72%, 187/861) had a significantly higher seroprevalence than control subjects (8.25%, 71/861) (<jats:italic>P</jats:italic> < 0.001). Among them, 144 (16.72%) oral cancer patients and 71 (8.25%) control subjects were positive for IgG antibodies to <jats:italic>T. gondii</jats:italic>, while 54 (6.27%) oral cancer patients and 9 (1.05%) controls were positive for IgM antibodies to <jats:italic>T. gondii</jats:italic>. In addition, multiple logistic analysis showed that <jats:italic>T. gondii</jats:italic> infection in oral cancer patients was associated with blood transfusion history, keeping cats at home, and oyster consumption. To our knowledge, this is the first study that provided a serological evidence of an association between <jats:italic>T. gondii</jats:italic> infection and oral cancer patients. However, further studies are necessary to elucidate the role of <jats:italic>T. gondii</jats:italic> in oral cancer patients.</jats:p> Seroprevalence and risk factors of <i>Toxoplasma gondii</i> infection in oral cancer patients in China: a case–control prospective study Epidemiology and Infection |
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| title |
Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| title_unstemmed |
Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| title_full |
Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| title_fullStr |
Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| title_full_unstemmed |
Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| title_short |
Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| title_sort |
seroprevalence and risk factors of <i>toxoplasma gondii</i> infection in oral cancer patients in china: a case–control prospective study |
| topic |
Infectious Diseases Epidemiology |
| url |
http://dx.doi.org/10.1017/s0950268818001978 |
| publishDate |
2018 |
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1891-1895 |
| description |
<jats:title>Abstract</jats:title><jats:p>Over the recent years, potential associations between <jats:italic>Toxoplasma gondii</jats:italic> (<jats:italic>T. gondii</jats:italic>) infection and cancer risk have attracted a lot of attention. Nevertheless, the association between <jats:italic>T. gondii</jats:italic> infection and oral cancer remains relatively unexplored. We performed a case–control study of 861 oral cancer patients and 861 control subjects from eastern China with the aim to detect antibodies to <jats:italic>T. gondii</jats:italic> by enzyme-linked immunosorbent assay (ELISA) in these patients. The results showed that oral cancer patients (21.72%, 187/861) had a significantly higher seroprevalence than control subjects (8.25%, 71/861) (<jats:italic>P</jats:italic> < 0.001). Among them, 144 (16.72%) oral cancer patients and 71 (8.25%) control subjects were positive for IgG antibodies to <jats:italic>T. gondii</jats:italic>, while 54 (6.27%) oral cancer patients and 9 (1.05%) controls were positive for IgM antibodies to <jats:italic>T. gondii</jats:italic>. In addition, multiple logistic analysis showed that <jats:italic>T. gondii</jats:italic> infection in oral cancer patients was associated with blood transfusion history, keeping cats at home, and oyster consumption. To our knowledge, this is the first study that provided a serological evidence of an association between <jats:italic>T. gondii</jats:italic> infection and oral cancer patients. However, further studies are necessary to elucidate the role of <jats:italic>T. gondii</jats:italic> in oral cancer patients.</jats:p> |
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| author | Zhou, N., Zhang, X. Y., Li, Y. X., Wang, L., Wang, L. L., Cong, W. |
| author_facet | Zhou, N., Zhang, X. Y., Li, Y. X., Wang, L., Wang, L. L., Cong, W., Zhou, N., Zhang, X. Y., Li, Y. X., Wang, L., Wang, L. L., Cong, W. |
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| description | <jats:title>Abstract</jats:title><jats:p>Over the recent years, potential associations between <jats:italic>Toxoplasma gondii</jats:italic> (<jats:italic>T. gondii</jats:italic>) infection and cancer risk have attracted a lot of attention. Nevertheless, the association between <jats:italic>T. gondii</jats:italic> infection and oral cancer remains relatively unexplored. We performed a case–control study of 861 oral cancer patients and 861 control subjects from eastern China with the aim to detect antibodies to <jats:italic>T. gondii</jats:italic> by enzyme-linked immunosorbent assay (ELISA) in these patients. The results showed that oral cancer patients (21.72%, 187/861) had a significantly higher seroprevalence than control subjects (8.25%, 71/861) (<jats:italic>P</jats:italic> < 0.001). Among them, 144 (16.72%) oral cancer patients and 71 (8.25%) control subjects were positive for IgG antibodies to <jats:italic>T. gondii</jats:italic>, while 54 (6.27%) oral cancer patients and 9 (1.05%) controls were positive for IgM antibodies to <jats:italic>T. gondii</jats:italic>. In addition, multiple logistic analysis showed that <jats:italic>T. gondii</jats:italic> infection in oral cancer patients was associated with blood transfusion history, keeping cats at home, and oyster consumption. To our knowledge, this is the first study that provided a serological evidence of an association between <jats:italic>T. gondii</jats:italic> infection and oral cancer patients. However, further studies are necessary to elucidate the role of <jats:italic>T. gondii</jats:italic> in oral cancer patients.</jats:p> |
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| spelling | Zhou, N. Zhang, X. Y. Li, Y. X. Wang, L. Wang, L. L. Cong, W. 0950-2688 1469-4409 Cambridge University Press (CUP) Infectious Diseases Epidemiology http://dx.doi.org/10.1017/s0950268818001978 <jats:title>Abstract</jats:title><jats:p>Over the recent years, potential associations between <jats:italic>Toxoplasma gondii</jats:italic> (<jats:italic>T. gondii</jats:italic>) infection and cancer risk have attracted a lot of attention. Nevertheless, the association between <jats:italic>T. gondii</jats:italic> infection and oral cancer remains relatively unexplored. We performed a case–control study of 861 oral cancer patients and 861 control subjects from eastern China with the aim to detect antibodies to <jats:italic>T. gondii</jats:italic> by enzyme-linked immunosorbent assay (ELISA) in these patients. The results showed that oral cancer patients (21.72%, 187/861) had a significantly higher seroprevalence than control subjects (8.25%, 71/861) (<jats:italic>P</jats:italic> < 0.001). Among them, 144 (16.72%) oral cancer patients and 71 (8.25%) control subjects were positive for IgG antibodies to <jats:italic>T. gondii</jats:italic>, while 54 (6.27%) oral cancer patients and 9 (1.05%) controls were positive for IgM antibodies to <jats:italic>T. gondii</jats:italic>. In addition, multiple logistic analysis showed that <jats:italic>T. gondii</jats:italic> infection in oral cancer patients was associated with blood transfusion history, keeping cats at home, and oyster consumption. To our knowledge, this is the first study that provided a serological evidence of an association between <jats:italic>T. gondii</jats:italic> infection and oral cancer patients. However, further studies are necessary to elucidate the role of <jats:italic>T. gondii</jats:italic> in oral cancer patients.</jats:p> Seroprevalence and risk factors of <i>Toxoplasma gondii</i> infection in oral cancer patients in China: a case–control prospective study Epidemiology and Infection |
| spellingShingle | Zhou, N., Zhang, X. Y., Li, Y. X., Wang, L., Wang, L. L., Cong, W., Epidemiology and Infection, Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study, Infectious Diseases, Epidemiology |
| title | Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| title_full | Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| title_fullStr | Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| title_full_unstemmed | Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| title_short | Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| title_sort | seroprevalence and risk factors of <i>toxoplasma gondii</i> infection in oral cancer patients in china: a case–control prospective study |
| title_unstemmed | Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study |
| topic | Infectious Diseases, Epidemiology |
| url | http://dx.doi.org/10.1017/s0950268818001978 |