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Seroprevalence and risk factors of Toxoplasma gondii infection in oral cancer patients in China: a case–control prospective study
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| Zeitschriftentitel: | Epidemiology and Infection |
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| Personen und Körperschaften: | , , , , , |
| In: | Epidemiology and Infection, 146, 2018, 15, S. 1891-1895 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge University Press (CUP)
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>Abstract</jats:title><jats:p>Over the recent years, potential associations between <jats:italic>Toxoplasma gondii</jats:italic> (<jats:italic>T. gondii</jats:italic>) infection and cancer risk have attracted a lot of attention. Nevertheless, the association between <jats:italic>T. gondii</jats:italic> infection and oral cancer remains relatively unexplored. We performed a case–control study of 861 oral cancer patients and 861 control subjects from eastern China with the aim to detect antibodies to <jats:italic>T. gondii</jats:italic> by enzyme-linked immunosorbent assay (ELISA) in these patients. The results showed that oral cancer patients (21.72%, 187/861) had a significantly higher seroprevalence than control subjects (8.25%, 71/861) (<jats:italic>P</jats:italic> < 0.001). Among them, 144 (16.72%) oral cancer patients and 71 (8.25%) control subjects were positive for IgG antibodies to <jats:italic>T. gondii</jats:italic>, while 54 (6.27%) oral cancer patients and 9 (1.05%) controls were positive for IgM antibodies to <jats:italic>T. gondii</jats:italic>. In addition, multiple logistic analysis showed that <jats:italic>T. gondii</jats:italic> infection in oral cancer patients was associated with blood transfusion history, keeping cats at home, and oyster consumption. To our knowledge, this is the first study that provided a serological evidence of an association between <jats:italic>T. gondii</jats:italic> infection and oral cancer patients. However, further studies are necessary to elucidate the role of <jats:italic>T. gondii</jats:italic> in oral cancer patients.</jats:p> |
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| Umfang: | 1891-1895 |
| ISSN: |
0950-2688
1469-4409 |
| DOI: | 10.1017/s0950268818001978 |