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The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila
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| Zeitschriftentitel: | Genetical Research |
|---|---|
| Personen und Körperschaften: | , |
| In: | Genetical Research, 59, 1992, 3, S. 189-198 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Torres, Miguel Sanchez, Lucas Torres, Miguel Sanchez, Lucas |
|---|---|
| author |
Torres, Miguel Sanchez, Lucas |
| spellingShingle |
Torres, Miguel Sanchez, Lucas Genetical Research The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila Genetics General Medicine |
| author_sort |
torres, miguel |
| spelling |
Torres, Miguel Sanchez, Lucas 0016-6723 1469-5073 Hindawi Limited Genetics General Medicine http://dx.doi.org/10.1017/s0016672300030470 <jats:title>Summary</jats:title><jats:p>In<jats:italic>Drosophila</jats:italic>, sex is determined by the relative number of X chromosomes to autosomal sets (X: A ratio). The amount of products from several X-linked genes, called<jats:italic>sisterless</jats:italic>elements, is used to indicate to<jats:italic>Sex-lethal</jats:italic>the relative number of X chromosomes present in the cell. In response to the X: A signal,<jats:italic>Sex-lethal</jats:italic>is activated in females but remains inactive in males, being responsible for the control of both sex determination and dosage compensation. Here we find that the X-linked segmentation gene<jats:italic>runt</jats:italic>plays a role in this process. Reduced function of runt results in femalespecific lethality and sexual transformation of XX animals that are heterozygous for<jats:italic>Sxl</jats:italic>or<jats:italic>sis</jats:italic>loss-of-function mutations. These interactions are suppressed by<jats:italic>Sxl</jats:italic><jats:sub><jats:italic>MI</jats:italic></jats:sub>, a mutation that constitutively expresses female<jats:italic>Sex-lethal</jats:italic>functions, and occur at the time when the X: A signal determines<jats:italic>Sex-lethal</jats:italic>activity. Moreover, the presence of a loss-of-function<jats:italic>runt</jats:italic>mutation masculinizes triploid intersexes. On the other hand,<jats:italic>runt</jats:italic>duplications cause a reduction in male viability by ectopic activation of<jats:italic>Sex-lethal</jats:italic>. We conclude that<jats:italic>runt</jats:italic>is needed for the initial step of<jats:italic>Sex-lethal</jats:italic>activation, but does not have a major role as an X-counting element.</jats:p> The segmentation gene<i>runt</i>is needed to activate<i>Sex-lethal</i>, a gene that controls sex determination and dosage compensation in<i>Drosophila</i> Genetical Research |
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10.1017/s0016672300030470 |
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Hindawi Limited, 1992 |
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1992 |
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Hindawi Limited |
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Genetical Research |
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49 |
| title |
The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| title_unstemmed |
The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| title_full |
The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| title_fullStr |
The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| title_full_unstemmed |
The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| title_short |
The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| title_sort |
the segmentation gene<i>runt</i>is needed to activate<i>sex-lethal</i>, a gene that controls sex determination and dosage compensation in<i>drosophila</i> |
| topic |
Genetics General Medicine |
| url |
http://dx.doi.org/10.1017/s0016672300030470 |
| publishDate |
1992 |
| physical |
189-198 |
| description |
<jats:title>Summary</jats:title><jats:p>In<jats:italic>Drosophila</jats:italic>, sex is determined by the relative number of X chromosomes to autosomal sets (X: A ratio). The amount of products from several X-linked genes, called<jats:italic>sisterless</jats:italic>elements, is used to indicate to<jats:italic>Sex-lethal</jats:italic>the relative number of X chromosomes present in the cell. In response to the X: A signal,<jats:italic>Sex-lethal</jats:italic>is activated in females but remains inactive in males, being responsible for the control of both sex determination and dosage compensation. Here we find that the X-linked segmentation gene<jats:italic>runt</jats:italic>plays a role in this process. Reduced function of runt results in femalespecific lethality and sexual transformation of XX animals that are heterozygous for<jats:italic>Sxl</jats:italic>or<jats:italic>sis</jats:italic>loss-of-function mutations. These interactions are suppressed by<jats:italic>Sxl</jats:italic><jats:sub><jats:italic>MI</jats:italic></jats:sub>, a mutation that constitutively expresses female<jats:italic>Sex-lethal</jats:italic>functions, and occur at the time when the X: A signal determines<jats:italic>Sex-lethal</jats:italic>activity. Moreover, the presence of a loss-of-function<jats:italic>runt</jats:italic>mutation masculinizes triploid intersexes. On the other hand,<jats:italic>runt</jats:italic>duplications cause a reduction in male viability by ectopic activation of<jats:italic>Sex-lethal</jats:italic>. We conclude that<jats:italic>runt</jats:italic>is needed for the initial step of<jats:italic>Sex-lethal</jats:italic>activation, but does not have a major role as an X-counting element.</jats:p> |
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| description | <jats:title>Summary</jats:title><jats:p>In<jats:italic>Drosophila</jats:italic>, sex is determined by the relative number of X chromosomes to autosomal sets (X: A ratio). The amount of products from several X-linked genes, called<jats:italic>sisterless</jats:italic>elements, is used to indicate to<jats:italic>Sex-lethal</jats:italic>the relative number of X chromosomes present in the cell. In response to the X: A signal,<jats:italic>Sex-lethal</jats:italic>is activated in females but remains inactive in males, being responsible for the control of both sex determination and dosage compensation. Here we find that the X-linked segmentation gene<jats:italic>runt</jats:italic>plays a role in this process. Reduced function of runt results in femalespecific lethality and sexual transformation of XX animals that are heterozygous for<jats:italic>Sxl</jats:italic>or<jats:italic>sis</jats:italic>loss-of-function mutations. These interactions are suppressed by<jats:italic>Sxl</jats:italic><jats:sub><jats:italic>MI</jats:italic></jats:sub>, a mutation that constitutively expresses female<jats:italic>Sex-lethal</jats:italic>functions, and occur at the time when the X: A signal determines<jats:italic>Sex-lethal</jats:italic>activity. Moreover, the presence of a loss-of-function<jats:italic>runt</jats:italic>mutation masculinizes triploid intersexes. On the other hand,<jats:italic>runt</jats:italic>duplications cause a reduction in male viability by ectopic activation of<jats:italic>Sex-lethal</jats:italic>. We conclude that<jats:italic>runt</jats:italic>is needed for the initial step of<jats:italic>Sex-lethal</jats:italic>activation, but does not have a major role as an X-counting element.</jats:p> |
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| series | Genetical Research |
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| spelling | Torres, Miguel Sanchez, Lucas 0016-6723 1469-5073 Hindawi Limited Genetics General Medicine http://dx.doi.org/10.1017/s0016672300030470 <jats:title>Summary</jats:title><jats:p>In<jats:italic>Drosophila</jats:italic>, sex is determined by the relative number of X chromosomes to autosomal sets (X: A ratio). The amount of products from several X-linked genes, called<jats:italic>sisterless</jats:italic>elements, is used to indicate to<jats:italic>Sex-lethal</jats:italic>the relative number of X chromosomes present in the cell. In response to the X: A signal,<jats:italic>Sex-lethal</jats:italic>is activated in females but remains inactive in males, being responsible for the control of both sex determination and dosage compensation. Here we find that the X-linked segmentation gene<jats:italic>runt</jats:italic>plays a role in this process. Reduced function of runt results in femalespecific lethality and sexual transformation of XX animals that are heterozygous for<jats:italic>Sxl</jats:italic>or<jats:italic>sis</jats:italic>loss-of-function mutations. These interactions are suppressed by<jats:italic>Sxl</jats:italic><jats:sub><jats:italic>MI</jats:italic></jats:sub>, a mutation that constitutively expresses female<jats:italic>Sex-lethal</jats:italic>functions, and occur at the time when the X: A signal determines<jats:italic>Sex-lethal</jats:italic>activity. Moreover, the presence of a loss-of-function<jats:italic>runt</jats:italic>mutation masculinizes triploid intersexes. On the other hand,<jats:italic>runt</jats:italic>duplications cause a reduction in male viability by ectopic activation of<jats:italic>Sex-lethal</jats:italic>. We conclude that<jats:italic>runt</jats:italic>is needed for the initial step of<jats:italic>Sex-lethal</jats:italic>activation, but does not have a major role as an X-counting element.</jats:p> The segmentation gene<i>runt</i>is needed to activate<i>Sex-lethal</i>, a gene that controls sex determination and dosage compensation in<i>Drosophila</i> Genetical Research |
| spellingShingle | Torres, Miguel, Sanchez, Lucas, Genetical Research, The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila, Genetics, General Medicine |
| title | The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| title_full | The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| title_fullStr | The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| title_full_unstemmed | The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| title_short | The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| title_sort | the segmentation gene<i>runt</i>is needed to activate<i>sex-lethal</i>, a gene that controls sex determination and dosage compensation in<i>drosophila</i> |
| title_unstemmed | The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila |
| topic | Genetics, General Medicine |
| url | http://dx.doi.org/10.1017/s0016672300030470 |