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The segmentation generuntis needed to activateSex-lethal, a gene that controls sex determination and dosage compensation inDrosophila
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| Zeitschriftentitel: | Genetical Research |
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| Personen und Körperschaften: | , |
| In: | Genetical Research, 59, 1992, 3, S. 189-198 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>Summary</jats:title><jats:p>In<jats:italic>Drosophila</jats:italic>, sex is determined by the relative number of X chromosomes to autosomal sets (X: A ratio). The amount of products from several X-linked genes, called<jats:italic>sisterless</jats:italic>elements, is used to indicate to<jats:italic>Sex-lethal</jats:italic>the relative number of X chromosomes present in the cell. In response to the X: A signal,<jats:italic>Sex-lethal</jats:italic>is activated in females but remains inactive in males, being responsible for the control of both sex determination and dosage compensation. Here we find that the X-linked segmentation gene<jats:italic>runt</jats:italic>plays a role in this process. Reduced function of runt results in femalespecific lethality and sexual transformation of XX animals that are heterozygous for<jats:italic>Sxl</jats:italic>or<jats:italic>sis</jats:italic>loss-of-function mutations. These interactions are suppressed by<jats:italic>Sxl</jats:italic><jats:sub><jats:italic>MI</jats:italic></jats:sub>, a mutation that constitutively expresses female<jats:italic>Sex-lethal</jats:italic>functions, and occur at the time when the X: A signal determines<jats:italic>Sex-lethal</jats:italic>activity. Moreover, the presence of a loss-of-function<jats:italic>runt</jats:italic>mutation masculinizes triploid intersexes. On the other hand,<jats:italic>runt</jats:italic>duplications cause a reduction in male viability by ectopic activation of<jats:italic>Sex-lethal</jats:italic>. We conclude that<jats:italic>runt</jats:italic>is needed for the initial step of<jats:italic>Sex-lethal</jats:italic>activation, but does not have a major role as an X-counting element.</jats:p> |
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| Umfang: | 189-198 |
| ISSN: |
0016-6723
1469-5073 |
| DOI: | 10.1017/s0016672300030470 |