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Biochemical and genetic characterization of esterase-27 (ES-27), the major plasma cholinesterase of the house mouse (Mus musculus)
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| Zeitschriftentitel: | Genetical Research |
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| Personen und Körperschaften: | , |
| In: | Genetical Research, 57, 1991, 1, S. 61-70 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>Summary</jats:title><jats:p>Esterase-27A (ES-27A) was characterized in strain A/WySnA by a cascade of seven bands seen after disc electrophoresis of serum and subsequent staining for esterase. ES-27A catalyses the hydrolysis of thiocholine butyrate and is strongly inhibited by 100 μ<jats:sc>m</jats:sc> tetraisopropyl pyrophosphamide (isoOMPA). Hence, the enzyme was concluded to be a cholinesterase EC 3.1.1.8. A heat-labile form termed ES-27B was represented by strain AKR/Han. From a three-point cross (AKR/Han, A/Wy) and a five-point cross (AKR/Han, SEG/1), the gene order on chromosome 3 was concluded to be centromere–<jats:italic>Car-2–Es-26–Es-27–Amy-1–Adh-1</jats:italic>.</jats:p> |
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| Umfang: | 61-70 |
| ISSN: |
0016-6723
1469-5073 |
| DOI: | 10.1017/s0016672300029050 |