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TGF‐β control of stem cell differentiation genes
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| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , |
| In: | FEBS Letters, 586, 2012, 14, S. 1953-1958 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Massagué, Joan Xi, Qiaoran Massagué, Joan Xi, Qiaoran |
|---|---|
| author |
Massagué, Joan Xi, Qiaoran |
| spellingShingle |
Massagué, Joan Xi, Qiaoran FEBS Letters TGF‐β control of stem cell differentiation genes Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
massagué, joan |
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Massagué, Joan Xi, Qiaoran 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/j.febslet.2012.03.023 <jats:p>The canonical TGF‐β/Smad signaling pathway was delineated in the mid 90s and enriched over the past decade with many findings about its specificity, regulation, networking, and malfunctions in disease. However, a growing understanding of the chromatin status of a critical class of TGF‐β target genes – the genes controlling differentiation of embryonic stem cells – recently prompted a reexamination of this pathway and its critical role in the regulation of stem cell differentiation. The new findings reveal master regulators of the pluripotent state set the stage for Smad‐mediated activation of master regulators of the next differentiation stage. Furthermore, a novel branch of the TGF‐β/Smad pathway has been identified in which a chromatin‐reading Smad complex makes the master differentiation genes accessible to canonical Smad complexes for transcriptional activation. These findings provide exciting new insights into the global role of TGF‐β signaling in the regulators of stem cell fate.</jats:p> TGF‐β control of stem cell differentiation genes FEBS Letters |
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Wiley, 2012 |
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Wiley, 2012 |
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FEBS Letters |
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TGF‐β control of stem cell differentiation genes |
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TGF‐β control of stem cell differentiation genes |
| title_full |
TGF‐β control of stem cell differentiation genes |
| title_fullStr |
TGF‐β control of stem cell differentiation genes |
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TGF‐β control of stem cell differentiation genes |
| title_short |
TGF‐β control of stem cell differentiation genes |
| title_sort |
tgf‐β control of stem cell differentiation genes |
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Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
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http://dx.doi.org/10.1016/j.febslet.2012.03.023 |
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2012 |
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1953-1958 |
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<jats:p>The canonical TGF‐β/Smad signaling pathway was delineated in the mid 90s and enriched over the past decade with many findings about its specificity, regulation, networking, and malfunctions in disease. However, a growing understanding of the chromatin status of a critical class of TGF‐β target genes – the genes controlling differentiation of embryonic stem cells – recently prompted a reexamination of this pathway and its critical role in the regulation of stem cell differentiation. The new findings reveal master regulators of the pluripotent state set the stage for Smad‐mediated activation of master regulators of the next differentiation stage. Furthermore, a novel branch of the TGF‐β/Smad pathway has been identified in which a chromatin‐reading Smad complex makes the master differentiation genes accessible to canonical Smad complexes for transcriptional activation. These findings provide exciting new insights into the global role of TGF‐β signaling in the regulators of stem cell fate.</jats:p> |
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| author | Massagué, Joan, Xi, Qiaoran |
| author_facet | Massagué, Joan, Xi, Qiaoran, Massagué, Joan, Xi, Qiaoran |
| author_sort | massagué, joan |
| container_issue | 14 |
| container_start_page | 1953 |
| container_title | FEBS Letters |
| container_volume | 586 |
| description | <jats:p>The canonical TGF‐β/Smad signaling pathway was delineated in the mid 90s and enriched over the past decade with many findings about its specificity, regulation, networking, and malfunctions in disease. However, a growing understanding of the chromatin status of a critical class of TGF‐β target genes – the genes controlling differentiation of embryonic stem cells – recently prompted a reexamination of this pathway and its critical role in the regulation of stem cell differentiation. The new findings reveal master regulators of the pluripotent state set the stage for Smad‐mediated activation of master regulators of the next differentiation stage. Furthermore, a novel branch of the TGF‐β/Smad pathway has been identified in which a chromatin‐reading Smad complex makes the master differentiation genes accessible to canonical Smad complexes for transcriptional activation. These findings provide exciting new insights into the global role of TGF‐β signaling in the regulators of stem cell fate.</jats:p> |
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| imprint | Wiley, 2012 |
| imprint_str_mv | Wiley, 2012 |
| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4 |
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| physical | 1953-1958 |
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| recordtype | ai |
| series | FEBS Letters |
| source_id | 49 |
| spelling | Massagué, Joan Xi, Qiaoran 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/j.febslet.2012.03.023 <jats:p>The canonical TGF‐β/Smad signaling pathway was delineated in the mid 90s and enriched over the past decade with many findings about its specificity, regulation, networking, and malfunctions in disease. However, a growing understanding of the chromatin status of a critical class of TGF‐β target genes – the genes controlling differentiation of embryonic stem cells – recently prompted a reexamination of this pathway and its critical role in the regulation of stem cell differentiation. The new findings reveal master regulators of the pluripotent state set the stage for Smad‐mediated activation of master regulators of the next differentiation stage. Furthermore, a novel branch of the TGF‐β/Smad pathway has been identified in which a chromatin‐reading Smad complex makes the master differentiation genes accessible to canonical Smad complexes for transcriptional activation. These findings provide exciting new insights into the global role of TGF‐β signaling in the regulators of stem cell fate.</jats:p> TGF‐β control of stem cell differentiation genes FEBS Letters |
| spellingShingle | Massagué, Joan, Xi, Qiaoran, FEBS Letters, TGF‐β control of stem cell differentiation genes, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | TGF‐β control of stem cell differentiation genes |
| title_full | TGF‐β control of stem cell differentiation genes |
| title_fullStr | TGF‐β control of stem cell differentiation genes |
| title_full_unstemmed | TGF‐β control of stem cell differentiation genes |
| title_short | TGF‐β control of stem cell differentiation genes |
| title_sort | tgf‐β control of stem cell differentiation genes |
| title_unstemmed | TGF‐β control of stem cell differentiation genes |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1016/j.febslet.2012.03.023 |