Eintrag weiter verarbeiten
TGF‐β control of stem cell differentiation genes
Gespeichert in:
| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , |
| In: | FEBS Letters, 586, 2012, 14, S. 1953-1958 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| Zusammenfassung: | <jats:p>The canonical TGF‐β/Smad signaling pathway was delineated in the mid 90s and enriched over the past decade with many findings about its specificity, regulation, networking, and malfunctions in disease. However, a growing understanding of the chromatin status of a critical class of TGF‐β target genes – the genes controlling differentiation of embryonic stem cells – recently prompted a reexamination of this pathway and its critical role in the regulation of stem cell differentiation. The new findings reveal master regulators of the pluripotent state set the stage for Smad‐mediated activation of master regulators of the next differentiation stage. Furthermore, a novel branch of the TGF‐β/Smad pathway has been identified in which a chromatin‐reading Smad complex makes the master differentiation genes accessible to canonical Smad complexes for transcriptional activation. These findings provide exciting new insights into the global role of TGF‐β signaling in the regulators of stem cell fate.</jats:p> |
|---|---|
| Umfang: | 1953-1958 |
| ISSN: |
1873-3468
0014-5793 |
| DOI: | 10.1016/j.febslet.2012.03.023 |