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Use of reference libraries and hybridisation fingerprinting for relational genome analysis
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| Zeitschriftentitel: | FEBS Letters |
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| Personen und Körperschaften: | , |
| In: | FEBS Letters, 325, 1993, 1-2, S. 118-122 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| Zusammenfassung: | <jats:p>The concept of relational genome analysis by hybridisation has been developed into a working system. Various genomic and cDNA libraries have been generated and are distributed via a reference system. Analysis procedures have been tested successfully in the mapping of the entire <jats:italic>Schizosaccharomyces pombe</jats:italic> genome. In another test‐case for their refinement, analyses on the <jats:italic>Drosophila</jats:italic> genome are well under way. Human and mouse libraries are being studied on all levels, from generating YAC maps to partially sequencing representative cDNA libraries. The automation of the involved processes and the development of improved image detection and analysis are well advanced.</jats:p> |
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| Umfang: | 118-122 |
| ISSN: |
0014-5793
1873-3468 |
| DOI: | 10.1016/0014-5793(93)81426-z |