Liver Injury and Failure in Critical Illness

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Bibliographische Detailangaben
Zeitschriftentitel:	Hepatology
Personen und Körperschaften:	Horvatits, Thomas, Drolz, Andreas, Trauner, Michael, Fuhrmann, Valentin
In:	Hepatology, 70, 2019, 6, S. 2204-2215
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Ovid Technologies (Wolters Kluwer Health)
Schlagwörter:	Hepatology

Details
Zusammenfassung:	<jats:p>The frequency of acquired liver injury and failure in critical illness has been significantly increasing over recent decades. Currently, liver injury and failure are observed in up to 20% of patients in intensive care units and are associated with significantly increased morbidity and mortality. Secondary forms of liver injury in critical illness are divided primarily into cholestatic, hypoxic, or mixed forms. Therefore, sufficient knowledge of underlying alterations (e.g., hemodynamic, inflammatory, or drug induced) is key to a better understanding of clinical manifestations, prognostic implications, as well as diagnostic and therapeutic options of acquired liver injury and failure. This review provides a structured approach for the evaluation and treatment of acquired liver injury and failure in critically ill patients.</jats:p>
Umfang:	2204-2215
ISSN:	0270-9139 1527-3350
DOI:	10.1002/hep.30824