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New therapeutic concepts in bile acid transport and signaling for management of cholestasis
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| Zeitschriftentitel: | Hepatology |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Hepatology, 65, 2017, 4, S. 1393-1404 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
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Trauner, Michael Fuchs, Claudia Daniela Halilbasic, Emina Paumgartner, Gustav Trauner, Michael Fuchs, Claudia Daniela Halilbasic, Emina Paumgartner, Gustav |
|---|---|
| author |
Trauner, Michael Fuchs, Claudia Daniela Halilbasic, Emina Paumgartner, Gustav |
| spellingShingle |
Trauner, Michael Fuchs, Claudia Daniela Halilbasic, Emina Paumgartner, Gustav Hepatology New therapeutic concepts in bile acid transport and signaling for management of cholestasis Hepatology |
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trauner, michael |
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Trauner, Michael Fuchs, Claudia Daniela Halilbasic, Emina Paumgartner, Gustav 0270-9139 1527-3350 Ovid Technologies (Wolters Kluwer Health) Hepatology http://dx.doi.org/10.1002/hep.28991 <jats:p>The identification of the key regulators of bile acid (BA) synthesis and transport within the enterohepatic circulation has revealed potential targets for pharmacological therapies of cholestatic liver diseases. Novel drug targets include the bile BA receptors, farnesoid X receptor and TGR5, the BA‐induced gut hormones, fibroblast growth factor 19 and glucagon‐like peptide 1, and the BA transport systems, apical sodium‐dependent bile acid transporter and Na<jats:sup>+</jats:sup>‐taurocholate cotransporting polypeptide, within the enterohepatic circulation. Moreover, BA derivatives undergoing cholehepatic shunting may allow improved targeting to the bile ducts. This review focuses on the pathophysiological basis, mechanisms of action, and clinical development of novel pharmacological strategies targeting BA transport and signaling in cholestatic liver diseases. (H<jats:sc>epatology</jats:sc> 2017;65:1393‐1404).</jats:p> New therapeutic concepts in bile acid transport and signaling for management of cholestasis Hepatology |
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| title |
New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_unstemmed |
New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_full |
New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_fullStr |
New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_full_unstemmed |
New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_short |
New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_sort |
new therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| topic |
Hepatology |
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http://dx.doi.org/10.1002/hep.28991 |
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2017 |
| physical |
1393-1404 |
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<jats:p>The identification of the key regulators of bile acid (BA) synthesis and transport within the enterohepatic circulation has revealed potential targets for pharmacological therapies of cholestatic liver diseases. Novel drug targets include the bile BA receptors, farnesoid X receptor and TGR5, the BA‐induced gut hormones, fibroblast growth factor 19 and glucagon‐like peptide 1, and the BA transport systems, apical sodium‐dependent bile acid transporter and Na<jats:sup>+</jats:sup>‐taurocholate cotransporting polypeptide, within the enterohepatic circulation. Moreover, BA derivatives undergoing cholehepatic shunting may allow improved targeting to the bile ducts. This review focuses on the pathophysiological basis, mechanisms of action, and clinical development of novel pharmacological strategies targeting BA transport and signaling in cholestatic liver diseases. (H<jats:sc>epatology</jats:sc> 2017;65:1393‐1404).</jats:p> |
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| description | <jats:p>The identification of the key regulators of bile acid (BA) synthesis and transport within the enterohepatic circulation has revealed potential targets for pharmacological therapies of cholestatic liver diseases. Novel drug targets include the bile BA receptors, farnesoid X receptor and TGR5, the BA‐induced gut hormones, fibroblast growth factor 19 and glucagon‐like peptide 1, and the BA transport systems, apical sodium‐dependent bile acid transporter and Na<jats:sup>+</jats:sup>‐taurocholate cotransporting polypeptide, within the enterohepatic circulation. Moreover, BA derivatives undergoing cholehepatic shunting may allow improved targeting to the bile ducts. This review focuses on the pathophysiological basis, mechanisms of action, and clinical development of novel pharmacological strategies targeting BA transport and signaling in cholestatic liver diseases. (H<jats:sc>epatology</jats:sc> 2017;65:1393‐1404).</jats:p> |
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| physical | 1393-1404 |
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| spelling | Trauner, Michael Fuchs, Claudia Daniela Halilbasic, Emina Paumgartner, Gustav 0270-9139 1527-3350 Ovid Technologies (Wolters Kluwer Health) Hepatology http://dx.doi.org/10.1002/hep.28991 <jats:p>The identification of the key regulators of bile acid (BA) synthesis and transport within the enterohepatic circulation has revealed potential targets for pharmacological therapies of cholestatic liver diseases. Novel drug targets include the bile BA receptors, farnesoid X receptor and TGR5, the BA‐induced gut hormones, fibroblast growth factor 19 and glucagon‐like peptide 1, and the BA transport systems, apical sodium‐dependent bile acid transporter and Na<jats:sup>+</jats:sup>‐taurocholate cotransporting polypeptide, within the enterohepatic circulation. Moreover, BA derivatives undergoing cholehepatic shunting may allow improved targeting to the bile ducts. This review focuses on the pathophysiological basis, mechanisms of action, and clinical development of novel pharmacological strategies targeting BA transport and signaling in cholestatic liver diseases. (H<jats:sc>epatology</jats:sc> 2017;65:1393‐1404).</jats:p> New therapeutic concepts in bile acid transport and signaling for management of cholestasis Hepatology |
| spellingShingle | Trauner, Michael, Fuchs, Claudia Daniela, Halilbasic, Emina, Paumgartner, Gustav, Hepatology, New therapeutic concepts in bile acid transport and signaling for management of cholestasis, Hepatology |
| title | New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_full | New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_fullStr | New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_full_unstemmed | New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_short | New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_sort | new therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| title_unstemmed | New therapeutic concepts in bile acid transport and signaling for management of cholestasis |
| topic | Hepatology |
| url | http://dx.doi.org/10.1002/hep.28991 |