New therapeutic concepts in bile acid transport and signaling for management of cholestasis

Gespeichert in:

Bibliographische Detailangaben
Zeitschriftentitel:	Hepatology
Personen und Körperschaften:	Trauner, Michael, Fuchs, Claudia Daniela, Halilbasic, Emina, Paumgartner, Gustav
In:	Hepatology, 65, 2017, 4, S. 1393-1404
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Ovid Technologies (Wolters Kluwer Health)
Schlagwörter:	Hepatology

Details
Zusammenfassung:	<jats:p>The identification of the key regulators of bile acid (BA) synthesis and transport within the enterohepatic circulation has revealed potential targets for pharmacological therapies of cholestatic liver diseases. Novel drug targets include the bile BA receptors, farnesoid X receptor and TGR5, the BA‐induced gut hormones, fibroblast growth factor 19 and glucagon‐like peptide 1, and the BA transport systems, apical sodium‐dependent bile acid transporter and Na<jats:sup>+</jats:sup>‐taurocholate cotransporting polypeptide, within the enterohepatic circulation. Moreover, BA derivatives undergoing cholehepatic shunting may allow improved targeting to the bile ducts. This review focuses on the pathophysiological basis, mechanisms of action, and clinical development of novel pharmacological strategies targeting BA transport and signaling in cholestatic liver diseases. (H<jats:sc>epatology</jats:sc> 2017;65:1393‐1404).</jats:p>
Umfang:	1393-1404
ISSN:	0270-9139 1527-3350
DOI:	10.1002/hep.28991