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Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium
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| Zeitschriftentitel: | Molecular Biology of the Cell |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Molecular Biology of the Cell, 32, 2021, 5, S. 413-421 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Cell Biology (ASCB)
|
| Schlagwörter: |
| author_facet |
Onken, Michael D. Blumer, Kendall J. Cooper, John A. Onken, Michael D. Blumer, Kendall J. Cooper, John A. |
|---|---|
| author |
Onken, Michael D. Blumer, Kendall J. Cooper, John A. |
| spellingShingle |
Onken, Michael D. Blumer, Kendall J. Cooper, John A. Molecular Biology of the Cell Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium Cell Biology Molecular Biology |
| author_sort |
onken, michael d. |
| spelling |
Onken, Michael D. Blumer, Kendall J. Cooper, John A. 1059-1524 1939-4586 American Society for Cell Biology (ASCB) Cell Biology Molecular Biology http://dx.doi.org/10.1091/mbc.e20-04-0241 <jats:p> Uveal melanoma is highly metastatic and only disseminates hematogenously, so that transendothelial migration is vital to metastasis. Uveal melanoma cells switch from amoeboid to mesenchymal motility, controlled by the Rho and Rac pathways, which act downstream of the oncogenic Gq/11 that drives tumor formation. </jats:p> Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium Molecular Biology of the Cell |
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| title |
Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_unstemmed |
Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_full |
Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_fullStr |
Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_full_unstemmed |
Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_short |
Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_sort |
uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| topic |
Cell Biology Molecular Biology |
| url |
http://dx.doi.org/10.1091/mbc.e20-04-0241 |
| publishDate |
2021 |
| physical |
413-421 |
| description |
<jats:p> Uveal melanoma is highly metastatic and only disseminates hematogenously, so that transendothelial migration is vital to metastasis. Uveal melanoma cells switch from amoeboid to mesenchymal motility, controlled by the Rho and Rac pathways, which act downstream of the oncogenic Gq/11 that drives tumor formation. </jats:p> |
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| author | Onken, Michael D., Blumer, Kendall J., Cooper, John A. |
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| author_sort | onken, michael d. |
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| container_start_page | 413 |
| container_title | Molecular Biology of the Cell |
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| description | <jats:p> Uveal melanoma is highly metastatic and only disseminates hematogenously, so that transendothelial migration is vital to metastasis. Uveal melanoma cells switch from amoeboid to mesenchymal motility, controlled by the Rho and Rac pathways, which act downstream of the oncogenic Gq/11 that drives tumor formation. </jats:p> |
| doi_str_mv | 10.1091/mbc.e20-04-0241 |
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| format | ElectronicArticle |
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| imprint | American Society for Cell Biology (ASCB), 2021 |
| imprint_str_mv | American Society for Cell Biology (ASCB), 2021 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 1059-1524, 1939-4586 |
| issn_str_mv | 1059-1524, 1939-4586 |
| language | English |
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| physical | 413-421 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher | American Society for Cell Biology (ASCB) |
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| recordtype | ai |
| series | Molecular Biology of the Cell |
| source_id | 49 |
| spelling | Onken, Michael D. Blumer, Kendall J. Cooper, John A. 1059-1524 1939-4586 American Society for Cell Biology (ASCB) Cell Biology Molecular Biology http://dx.doi.org/10.1091/mbc.e20-04-0241 <jats:p> Uveal melanoma is highly metastatic and only disseminates hematogenously, so that transendothelial migration is vital to metastasis. Uveal melanoma cells switch from amoeboid to mesenchymal motility, controlled by the Rho and Rac pathways, which act downstream of the oncogenic Gq/11 that drives tumor formation. </jats:p> Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium Molecular Biology of the Cell |
| spellingShingle | Onken, Michael D., Blumer, Kendall J., Cooper, John A., Molecular Biology of the Cell, Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium, Cell Biology, Molecular Biology |
| title | Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_full | Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_fullStr | Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_full_unstemmed | Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_short | Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_sort | uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| title_unstemmed | Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium |
| topic | Cell Biology, Molecular Biology |
| url | http://dx.doi.org/10.1091/mbc.e20-04-0241 |