Eintrag weiter verarbeiten
Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium
Gespeichert in:
| Zeitschriftentitel: | Molecular Biology of the Cell |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Molecular Biology of the Cell, 32, 2021, 5, S. 413-421 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Society for Cell Biology (ASCB)
|
| Schlagwörter: |
| Zusammenfassung: | <jats:p> Uveal melanoma is highly metastatic and only disseminates hematogenously, so that transendothelial migration is vital to metastasis. Uveal melanoma cells switch from amoeboid to mesenchymal motility, controlled by the Rho and Rac pathways, which act downstream of the oncogenic Gq/11 that drives tumor formation. </jats:p> |
|---|---|
| Umfang: | 413-421 |
| ISSN: |
1059-1524
1939-4586 |
| DOI: | 10.1091/mbc.e20-04-0241 |