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Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein

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Bibliographische Detailangaben
Zeitschriftentitel: Molecular Biology of the Cell
Personen und Körperschaften: Nouri-Nejad, Daniel, O’Donnell, Brooke L., Patil, Chetan S., Sanchez-Pupo, Rafael E., Johnston, Danielle, Sayedyahossein, Samar, Jurcic, Kristina, Lau, Rebecca, Gyenis, Laszlo, Litchfield, David W., Jackson, Michael F., Gloor, Gregory B., Penuela, Silvia
In: Molecular Biology of the Cell, 32, 2021, 5, S. 376-390
Format: E-Article
Sprache: Englisch
veröffentlicht:
American Society for Cell Biology (ASCB)
Schlagwörter:
Cell Biology
Molecular Biology
Details
Zusammenfassung: <jats:p> In this study, we discovered the first mutation in a phosphorylation site of pannexin 1 (PANX1) that affects phosphorylation, glycosylation, and trafficking of PANX1 channels in a melanoma patient tumor. We also reported on the ancestral allele of PANX1 that is the most representative variant within human populations. </jats:p>
Umfang: 376-390
ISSN: 1059-1524
1939-4586
DOI: 10.1091/mbc.e19-10-0585