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Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts

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Zeitschriftentitel: Proceedings of the National Academy of Sciences
Personen und Körperschaften: Wang, Zhiyan M., Yang, Hong, Livingston, David M.
In: Proceedings of the National Academy of Sciences, 95, 1998, 26, S. 15583-15586
Format: E-Article
Sprache: Englisch
veröffentlicht:
Proceedings of the National Academy of Sciences
Schlagwörter:
Multidisciplinary
author_facet Wang, Zhiyan M.
Yang, Hong
Livingston, David M.
Wang, Zhiyan M.
Yang, Hong
Livingston, David M.
author Wang, Zhiyan M.
Yang, Hong
Livingston, David M.
spellingShingle Wang, Zhiyan M.
Yang, Hong
Livingston, David M.
Proceedings of the National Academy of Sciences
Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
Multidisciplinary
author_sort wang, zhiyan m.
spelling Wang, Zhiyan M. Yang, Hong Livingston, David M. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.95.26.15583 <jats:p> Much evidence strongly suggests a positive role for one or more E2F species in the control of exit from G <jats:sub>0</jats:sub> /G <jats:sub>1</jats:sub> . Results described here provide direct evidence that endogenous E2F-1, as predicted, contributes to progression from G <jats:sub>0</jats:sub> to S. By contrast, cycling cells lacking an intact E2F-1 gene demonstrated normal cell cycle distribution. Therefore, E2F-1 exerts a unique function leading to timely G <jats:sub>0</jats:sub> exit of resting cultured primary cells, while at the same time being unnecessary for normal G <jats:sub>1</jats:sub> to S phase progression of cycling cells. </jats:p> Endogenous E2F-1 promotes timely G <sub>0</sub> exit of resting mouse embryo fibroblasts Proceedings of the National Academy of Sciences
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title Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
title_unstemmed Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
title_full Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
title_fullStr Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
title_full_unstemmed Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
title_short Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
title_sort endogenous e2f-1 promotes timely g <sub>0</sub> exit of resting mouse embryo fibroblasts
topic Multidisciplinary
url http://dx.doi.org/10.1073/pnas.95.26.15583
publishDate 1998
physical 15583-15586
description <jats:p> Much evidence strongly suggests a positive role for one or more E2F species in the control of exit from G <jats:sub>0</jats:sub> /G <jats:sub>1</jats:sub> . Results described here provide direct evidence that endogenous E2F-1, as predicted, contributes to progression from G <jats:sub>0</jats:sub> to S. By contrast, cycling cells lacking an intact E2F-1 gene demonstrated normal cell cycle distribution. Therefore, E2F-1 exerts a unique function leading to timely G <jats:sub>0</jats:sub> exit of resting cultured primary cells, while at the same time being unnecessary for normal G <jats:sub>1</jats:sub> to S phase progression of cycling cells. </jats:p>
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author Wang, Zhiyan M., Yang, Hong, Livingston, David M.
author_facet Wang, Zhiyan M., Yang, Hong, Livingston, David M., Wang, Zhiyan M., Yang, Hong, Livingston, David M.
author_sort wang, zhiyan m.
container_issue 26
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container_title Proceedings of the National Academy of Sciences
container_volume 95
description <jats:p> Much evidence strongly suggests a positive role for one or more E2F species in the control of exit from G <jats:sub>0</jats:sub> /G <jats:sub>1</jats:sub> . Results described here provide direct evidence that endogenous E2F-1, as predicted, contributes to progression from G <jats:sub>0</jats:sub> to S. By contrast, cycling cells lacking an intact E2F-1 gene demonstrated normal cell cycle distribution. Therefore, E2F-1 exerts a unique function leading to timely G <jats:sub>0</jats:sub> exit of resting cultured primary cells, while at the same time being unnecessary for normal G <jats:sub>1</jats:sub> to S phase progression of cycling cells. </jats:p>
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imprint Proceedings of the National Academy of Sciences, 1998
imprint_str_mv Proceedings of the National Academy of Sciences, 1998
institution DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229
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physical 15583-15586
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publisher Proceedings of the National Academy of Sciences
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spelling Wang, Zhiyan M. Yang, Hong Livingston, David M. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.95.26.15583 <jats:p> Much evidence strongly suggests a positive role for one or more E2F species in the control of exit from G <jats:sub>0</jats:sub> /G <jats:sub>1</jats:sub> . Results described here provide direct evidence that endogenous E2F-1, as predicted, contributes to progression from G <jats:sub>0</jats:sub> to S. By contrast, cycling cells lacking an intact E2F-1 gene demonstrated normal cell cycle distribution. Therefore, E2F-1 exerts a unique function leading to timely G <jats:sub>0</jats:sub> exit of resting cultured primary cells, while at the same time being unnecessary for normal G <jats:sub>1</jats:sub> to S phase progression of cycling cells. </jats:p> Endogenous E2F-1 promotes timely G <sub>0</sub> exit of resting mouse embryo fibroblasts Proceedings of the National Academy of Sciences
spellingShingle Wang, Zhiyan M., Yang, Hong, Livingston, David M., Proceedings of the National Academy of Sciences, Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts, Multidisciplinary
title Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
title_full Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
title_fullStr Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
title_full_unstemmed Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
title_short Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
title_sort endogenous e2f-1 promotes timely g <sub>0</sub> exit of resting mouse embryo fibroblasts
title_unstemmed Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
topic Multidisciplinary
url http://dx.doi.org/10.1073/pnas.95.26.15583