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Endogenous E2F-1 promotes timely G 0 exit of resting mouse embryo fibroblasts
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
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| Personen und Körperschaften: | , , |
| In: | Proceedings of the National Academy of Sciences, 95, 1998, 26, S. 15583-15586 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| Zusammenfassung: | <jats:p> Much evidence strongly suggests a positive role for one or more E2F species in the control of exit from G <jats:sub>0</jats:sub> /G <jats:sub>1</jats:sub> . Results described here provide direct evidence that endogenous E2F-1, as predicted, contributes to progression from G <jats:sub>0</jats:sub> to S. By contrast, cycling cells lacking an intact E2F-1 gene demonstrated normal cell cycle distribution. Therefore, E2F-1 exerts a unique function leading to timely G <jats:sub>0</jats:sub> exit of resting cultured primary cells, while at the same time being unnecessary for normal G <jats:sub>1</jats:sub> to S phase progression of cycling cells. </jats:p> |
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| Umfang: | 15583-15586 |
| ISSN: |
0027-8424
1091-6490 |
| DOI: | 10.1073/pnas.95.26.15583 |