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Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , |
| In: | Proceedings of the National Academy of Sciences, 69, 1972, 8, S. 2184-2188 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Nienhuis, Arthur W. Anderson, W. French Nienhuis, Arthur W. Anderson, W. French |
|---|---|
| author |
Nienhuis, Arthur W. Anderson, W. French |
| spellingShingle |
Nienhuis, Arthur W. Anderson, W. French Proceedings of the National Academy of Sciences Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells Multidisciplinary |
| author_sort |
nienhuis, arthur w. |
| spelling |
Nienhuis, Arthur W. Anderson, W. French 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.69.8.2184 <jats:p> Anemia causes a change in the type of circulating hemoglobin in goats and certain sheep: HbA (α <jats:sub>2</jats:sub> β <jats:sub>2</jats:sub> <jats:sup>A</jats:sup> ) is replaced by HbC (α <jats:sub>2</jats:sub> β <jats:sub>2</jats:sub> <jats:sup>C</jats:sup> ). We have isolated globin mRNA from erythroid cells of anemic and nonanemic animals to investigate the mechanism whereby anemia causes this switch. To study several stages in transition from β <jats:sup>A</jats:sup> to β <jats:sup>C</jats:sup> synthesis, active globin mRNA was isolated from bone marrow cells, as well as from reticulocytes. By assaying these globin mRNAs in a rabbit reticulocyte cell-free system, we have demonstrated that the switch from β <jats:sup>A</jats:sup> to β <jats:sup>C</jats:sup> globin synthesis is mediated via a change in functional globin mRNA. </jats:p> Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells Proceedings of the National Academy of Sciences |
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Proceedings of the National Academy of Sciences, 1972 |
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Proceedings of the National Academy of Sciences, 1972 |
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1972 |
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Proceedings of the National Academy of Sciences |
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49 |
| title |
Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| title_unstemmed |
Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| title_full |
Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| title_fullStr |
Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| title_full_unstemmed |
Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| title_short |
Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| title_sort |
hemoglobin switching in sheep and goats: change in functional globin messenger rna in reticulocytes and bone marrow cells |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.69.8.2184 |
| publishDate |
1972 |
| physical |
2184-2188 |
| description |
<jats:p>
Anemia causes a change in the type of circulating hemoglobin in goats and certain sheep: HbA (α
<jats:sub>2</jats:sub>
β
<jats:sub>2</jats:sub>
<jats:sup>A</jats:sup>
) is replaced by HbC (α
<jats:sub>2</jats:sub>
β
<jats:sub>2</jats:sub>
<jats:sup>C</jats:sup>
). We have isolated globin mRNA from erythroid cells of anemic and nonanemic animals to investigate the mechanism whereby anemia causes this switch. To study several stages in transition from β
<jats:sup>A</jats:sup>
to β
<jats:sup>C</jats:sup>
synthesis, active globin mRNA was isolated from bone marrow cells, as well as from reticulocytes. By assaying these globin mRNAs in a rabbit reticulocyte cell-free system, we have demonstrated that the switch from β
<jats:sup>A</jats:sup>
to β
<jats:sup>C</jats:sup>
globin synthesis is mediated via a change in functional globin mRNA.
</jats:p> |
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| description | <jats:p> Anemia causes a change in the type of circulating hemoglobin in goats and certain sheep: HbA (α <jats:sub>2</jats:sub> β <jats:sub>2</jats:sub> <jats:sup>A</jats:sup> ) is replaced by HbC (α <jats:sub>2</jats:sub> β <jats:sub>2</jats:sub> <jats:sup>C</jats:sup> ). We have isolated globin mRNA from erythroid cells of anemic and nonanemic animals to investigate the mechanism whereby anemia causes this switch. To study several stages in transition from β <jats:sup>A</jats:sup> to β <jats:sup>C</jats:sup> synthesis, active globin mRNA was isolated from bone marrow cells, as well as from reticulocytes. By assaying these globin mRNAs in a rabbit reticulocyte cell-free system, we have demonstrated that the switch from β <jats:sup>A</jats:sup> to β <jats:sup>C</jats:sup> globin synthesis is mediated via a change in functional globin mRNA. </jats:p> |
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| imprint | Proceedings of the National Academy of Sciences, 1972 |
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| physical | 2184-2188 |
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| spelling | Nienhuis, Arthur W. Anderson, W. French 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.69.8.2184 <jats:p> Anemia causes a change in the type of circulating hemoglobin in goats and certain sheep: HbA (α <jats:sub>2</jats:sub> β <jats:sub>2</jats:sub> <jats:sup>A</jats:sup> ) is replaced by HbC (α <jats:sub>2</jats:sub> β <jats:sub>2</jats:sub> <jats:sup>C</jats:sup> ). We have isolated globin mRNA from erythroid cells of anemic and nonanemic animals to investigate the mechanism whereby anemia causes this switch. To study several stages in transition from β <jats:sup>A</jats:sup> to β <jats:sup>C</jats:sup> synthesis, active globin mRNA was isolated from bone marrow cells, as well as from reticulocytes. By assaying these globin mRNAs in a rabbit reticulocyte cell-free system, we have demonstrated that the switch from β <jats:sup>A</jats:sup> to β <jats:sup>C</jats:sup> globin synthesis is mediated via a change in functional globin mRNA. </jats:p> Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells Proceedings of the National Academy of Sciences |
| spellingShingle | Nienhuis, Arthur W., Anderson, W. French, Proceedings of the National Academy of Sciences, Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells, Multidisciplinary |
| title | Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| title_full | Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| title_fullStr | Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| title_full_unstemmed | Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| title_short | Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| title_sort | hemoglobin switching in sheep and goats: change in functional globin messenger rna in reticulocytes and bone marrow cells |
| title_unstemmed | Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.69.8.2184 |