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Hemoglobin Switching in Sheep and Goats: Change in Functional Globin Messenger RNA in Reticulocytes and Bone Marrow Cells
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
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| Personen und Körperschaften: | , |
| In: | Proceedings of the National Academy of Sciences, 69, 1972, 8, S. 2184-2188 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| Zusammenfassung: | <jats:p> Anemia causes a change in the type of circulating hemoglobin in goats and certain sheep: HbA (α <jats:sub>2</jats:sub> β <jats:sub>2</jats:sub> <jats:sup>A</jats:sup> ) is replaced by HbC (α <jats:sub>2</jats:sub> β <jats:sub>2</jats:sub> <jats:sup>C</jats:sup> ). We have isolated globin mRNA from erythroid cells of anemic and nonanemic animals to investigate the mechanism whereby anemia causes this switch. To study several stages in transition from β <jats:sup>A</jats:sup> to β <jats:sup>C</jats:sup> synthesis, active globin mRNA was isolated from bone marrow cells, as well as from reticulocytes. By assaying these globin mRNAs in a rabbit reticulocyte cell-free system, we have demonstrated that the switch from β <jats:sup>A</jats:sup> to β <jats:sup>C</jats:sup> globin synthesis is mediated via a change in functional globin mRNA. </jats:p> |
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| Umfang: | 2184-2188 |
| ISSN: |
0027-8424
1091-6490 |
| DOI: | 10.1073/pnas.69.8.2184 |