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Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
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| Personen und Körperschaften: | , , , , , , , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 111, 2014, 9, S. 3544-3549 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| author_facet |
Magnus, Nathalie Garnier, Delphine Meehan, Brian McGraw, Serge Lee, Tae Hoon Caron, Maxime Bourque, Guillaume Milsom, Chloe Jabado, Nada Trasler, Jacquetta Pawlinski, Rafal Mackman, Nigel Rak, Janusz Magnus, Nathalie Garnier, Delphine Meehan, Brian McGraw, Serge Lee, Tae Hoon Caron, Maxime Bourque, Guillaume Milsom, Chloe Jabado, Nada Trasler, Jacquetta Pawlinski, Rafal Mackman, Nigel Rak, Janusz |
|---|---|
| author |
Magnus, Nathalie Garnier, Delphine Meehan, Brian McGraw, Serge Lee, Tae Hoon Caron, Maxime Bourque, Guillaume Milsom, Chloe Jabado, Nada Trasler, Jacquetta Pawlinski, Rafal Mackman, Nigel Rak, Janusz |
| spellingShingle |
Magnus, Nathalie Garnier, Delphine Meehan, Brian McGraw, Serge Lee, Tae Hoon Caron, Maxime Bourque, Guillaume Milsom, Chloe Jabado, Nada Trasler, Jacquetta Pawlinski, Rafal Mackman, Nigel Rak, Janusz Proceedings of the National Academy of Sciences Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations Multidisciplinary |
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magnus, nathalie |
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Magnus, Nathalie Garnier, Delphine Meehan, Brian McGraw, Serge Lee, Tae Hoon Caron, Maxime Bourque, Guillaume Milsom, Chloe Jabado, Nada Trasler, Jacquetta Pawlinski, Rafal Mackman, Nigel Rak, Janusz 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1314118111 <jats:title>Significance</jats:title> <jats:p>Our study shows that the clotting protein tissue factor (TF) controls the state of tumor dormancy and does so in conjunction with recruitment of inflammatory cells and blood vessels. We show that indolent glioma cells remain harmless in mice unless rendered TF positive. Our work also demonstrates the ability of TF to indirectly influence the DNA of cancer cells by facilitating gene mutations and silencing. This ability is important because injury, cardiovascular disease, or other conditions may activate the clotting system and contribute to the awakening of occult cancer cells. This understanding also may suggest a prophylactic use of blood thinners in cases where dormant cancer cells and clotting are suspected to coexist (e.g., after surgery).</jats:p> Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations Proceedings of the National Academy of Sciences |
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| title |
Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_unstemmed |
Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_full |
Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_fullStr |
Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_full_unstemmed |
Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_short |
Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_sort |
tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
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Multidisciplinary |
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http://dx.doi.org/10.1073/pnas.1314118111 |
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2014 |
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3544-3549 |
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<jats:title>Significance</jats:title>
<jats:p>Our study shows that the clotting protein tissue factor (TF) controls the state of tumor dormancy and does so in conjunction with recruitment of inflammatory cells and blood vessels. We show that indolent glioma cells remain harmless in mice unless rendered TF positive. Our work also demonstrates the ability of TF to indirectly influence the DNA of cancer cells by facilitating gene mutations and silencing. This ability is important because injury, cardiovascular disease, or other conditions may activate the clotting system and contribute to the awakening of occult cancer cells. This understanding also may suggest a prophylactic use of blood thinners in cases where dormant cancer cells and clotting are suspected to coexist (e.g., after surgery).</jats:p> |
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| author | Magnus, Nathalie, Garnier, Delphine, Meehan, Brian, McGraw, Serge, Lee, Tae Hoon, Caron, Maxime, Bourque, Guillaume, Milsom, Chloe, Jabado, Nada, Trasler, Jacquetta, Pawlinski, Rafal, Mackman, Nigel, Rak, Janusz |
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| description | <jats:title>Significance</jats:title> <jats:p>Our study shows that the clotting protein tissue factor (TF) controls the state of tumor dormancy and does so in conjunction with recruitment of inflammatory cells and blood vessels. We show that indolent glioma cells remain harmless in mice unless rendered TF positive. Our work also demonstrates the ability of TF to indirectly influence the DNA of cancer cells by facilitating gene mutations and silencing. This ability is important because injury, cardiovascular disease, or other conditions may activate the clotting system and contribute to the awakening of occult cancer cells. This understanding also may suggest a prophylactic use of blood thinners in cases where dormant cancer cells and clotting are suspected to coexist (e.g., after surgery).</jats:p> |
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| spelling | Magnus, Nathalie Garnier, Delphine Meehan, Brian McGraw, Serge Lee, Tae Hoon Caron, Maxime Bourque, Guillaume Milsom, Chloe Jabado, Nada Trasler, Jacquetta Pawlinski, Rafal Mackman, Nigel Rak, Janusz 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1314118111 <jats:title>Significance</jats:title> <jats:p>Our study shows that the clotting protein tissue factor (TF) controls the state of tumor dormancy and does so in conjunction with recruitment of inflammatory cells and blood vessels. We show that indolent glioma cells remain harmless in mice unless rendered TF positive. Our work also demonstrates the ability of TF to indirectly influence the DNA of cancer cells by facilitating gene mutations and silencing. This ability is important because injury, cardiovascular disease, or other conditions may activate the clotting system and contribute to the awakening of occult cancer cells. This understanding also may suggest a prophylactic use of blood thinners in cases where dormant cancer cells and clotting are suspected to coexist (e.g., after surgery).</jats:p> Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations Proceedings of the National Academy of Sciences |
| spellingShingle | Magnus, Nathalie, Garnier, Delphine, Meehan, Brian, McGraw, Serge, Lee, Tae Hoon, Caron, Maxime, Bourque, Guillaume, Milsom, Chloe, Jabado, Nada, Trasler, Jacquetta, Pawlinski, Rafal, Mackman, Nigel, Rak, Janusz, Proceedings of the National Academy of Sciences, Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations, Multidisciplinary |
| title | Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_full | Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_fullStr | Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_full_unstemmed | Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_short | Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_sort | tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| title_unstemmed | Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1314118111 |