Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations

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Bibliographische Detailangaben
Zeitschriftentitel:	Proceedings of the National Academy of Sciences
Personen und Körperschaften:	Magnus, Nathalie, Garnier, Delphine, Meehan, Brian, McGraw, Serge, Lee, Tae Hoon, Caron, Maxime, Bourque, Guillaume, Milsom, Chloe, Jabado, Nada, Trasler, Jacquetta, Pawlinski, Rafal, Mackman, Nigel, Rak, Janusz
In:	Proceedings of the National Academy of Sciences, 111, 2014, 9, S. 3544-3549
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Proceedings of the National Academy of Sciences
Schlagwörter:	Multidisciplinary

Details
Zusammenfassung:	<jats:title>Significance</jats:title> <jats:p>Our study shows that the clotting protein tissue factor (TF) controls the state of tumor dormancy and does so in conjunction with recruitment of inflammatory cells and blood vessels. We show that indolent glioma cells remain harmless in mice unless rendered TF positive. Our work also demonstrates the ability of TF to indirectly influence the DNA of cancer cells by facilitating gene mutations and silencing. This ability is important because injury, cardiovascular disease, or other conditions may activate the clotting system and contribute to the awakening of occult cancer cells. This understanding also may suggest a prophylactic use of blood thinners in cases where dormant cancer cells and clotting are suspected to coexist (e.g., after surgery).</jats:p>
Umfang:	3544-3549
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.1314118111