Eintrag weiter verarbeiten
I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits
Gespeichert in:
| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 110, 2013, 7 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
|
| Schlagwörter: |
| author_facet |
Ruscic, Katarina J. Miceli, Francesco Villalba-Galea, Carlos A. Dai, Hui Mishina, Yukiko Bezanilla, Francisco Goldstein, Steve A. N. Ruscic, Katarina J. Miceli, Francesco Villalba-Galea, Carlos A. Dai, Hui Mishina, Yukiko Bezanilla, Francisco Goldstein, Steve A. N. |
|---|---|
| author |
Ruscic, Katarina J. Miceli, Francesco Villalba-Galea, Carlos A. Dai, Hui Mishina, Yukiko Bezanilla, Francisco Goldstein, Steve A. N. |
| spellingShingle |
Ruscic, Katarina J. Miceli, Francesco Villalba-Galea, Carlos A. Dai, Hui Mishina, Yukiko Bezanilla, Francisco Goldstein, Steve A. N. Proceedings of the National Academy of Sciences I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits Multidisciplinary |
| author_sort |
ruscic, katarina j. |
| spelling |
Ruscic, Katarina J. Miceli, Francesco Villalba-Galea, Carlos A. Dai, Hui Mishina, Yukiko Bezanilla, Francisco Goldstein, Steve A. N. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1222616110 <jats:title>Significance</jats:title> <jats:p> E1 and Q1 protein subunits assemble to form I <jats:sub>Kslow</jats:sub> channels in the heart and ear. Inherited mutations in either subunit that decrease protein level or alter function can cause life-threatening cardiac arrhythmias and deafness. The mechanism by which E1 slows channel opening has been the subject of active debate. Here, we use gating current measurements and simultaneous recordings of ionic currents and changes in fluorescence of a probe on the Q1 voltage sensors to demonstrate that E1 slows the movement of sensors in a manner that is both necessary and sufficient to determine the slow activation time course of I <jats:sub>Ks</jats:sub> channels. </jats:p> I <sub>Ks</sub> channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits Proceedings of the National Academy of Sciences |
| doi_str_mv |
10.1073/pnas.1222616110 |
| facet_avail |
Online Free |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjEyMjI2MTYxMTA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjEyMjI2MTYxMTA |
| institution |
DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 |
| imprint |
Proceedings of the National Academy of Sciences, 2013 |
| imprint_str_mv |
Proceedings of the National Academy of Sciences, 2013 |
| issn |
0027-8424 1091-6490 |
| issn_str_mv |
0027-8424 1091-6490 |
| language |
English |
| mega_collection |
Proceedings of the National Academy of Sciences (CrossRef) |
| match_str |
ruscic2013ikschannelsopenslowlybecausekcne1accessorysubunitsslowthemovementofs4voltagesensorsinkcnq1poreformingsubunits |
| publishDateSort |
2013 |
| publisher |
Proceedings of the National Academy of Sciences |
| recordtype |
ai |
| record_format |
ai |
| series |
Proceedings of the National Academy of Sciences |
| source_id |
49 |
| title |
I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| title_unstemmed |
I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| title_full |
I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| title_fullStr |
I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| title_full_unstemmed |
I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| title_short |
I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| title_sort |
i
<sub>ks</sub>
channels open slowly because kcne1 accessory subunits slow the movement of s4 voltage sensors in kcnq1 pore-forming subunits |
| topic |
Multidisciplinary |
| url |
http://dx.doi.org/10.1073/pnas.1222616110 |
| publishDate |
2013 |
| physical |
|
| description |
<jats:title>Significance</jats:title>
<jats:p>
E1 and Q1 protein subunits assemble to form I
<jats:sub>Kslow</jats:sub>
channels in the heart and ear. Inherited mutations in either subunit that decrease protein level or alter function can cause life-threatening cardiac arrhythmias and deafness. The mechanism by which E1 slows channel opening has been the subject of active debate. Here, we use gating current measurements and simultaneous recordings of ionic currents and changes in fluorescence of a probe on the Q1 voltage sensors to demonstrate that E1 slows the movement of sensors in a manner that is both necessary and sufficient to determine the slow activation time course of I
<jats:sub>Ks</jats:sub>
channels.
</jats:p> |
| container_issue |
7 |
| container_start_page |
0 |
| container_title |
Proceedings of the National Academy of Sciences |
| container_volume |
110 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792345798552322054 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T17:29:13.63Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=I++++++++++++Ks++++++++++++channels+open+slowly+because+KCNE1+accessory+subunits+slow+the+movement+of+S4+voltage+sensors+in+KCNQ1+pore-forming+subunits&rft.date=2013-02-12&genre=article&issn=1091-6490&volume=110&issue=7&jtitle=Proceedings+of+the+National+Academy+of+Sciences&atitle=I%0A++++++++++++%3Csub%3EKs%3C%2Fsub%3E%0A++++++++++++channels+open+slowly+because+KCNE1+accessory+subunits+slow+the+movement+of+S4+voltage+sensors+in+KCNQ1+pore-forming+subunits&aulast=Goldstein&aufirst=Steve+A.+N.&rft_id=info%3Adoi%2F10.1073%2Fpnas.1222616110&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792345798552322054 |
| author | Ruscic, Katarina J., Miceli, Francesco, Villalba-Galea, Carlos A., Dai, Hui, Mishina, Yukiko, Bezanilla, Francisco, Goldstein, Steve A. N. |
| author_facet | Ruscic, Katarina J., Miceli, Francesco, Villalba-Galea, Carlos A., Dai, Hui, Mishina, Yukiko, Bezanilla, Francisco, Goldstein, Steve A. N., Ruscic, Katarina J., Miceli, Francesco, Villalba-Galea, Carlos A., Dai, Hui, Mishina, Yukiko, Bezanilla, Francisco, Goldstein, Steve A. N. |
| author_sort | ruscic, katarina j. |
| container_issue | 7 |
| container_start_page | 0 |
| container_title | Proceedings of the National Academy of Sciences |
| container_volume | 110 |
| description | <jats:title>Significance</jats:title> <jats:p> E1 and Q1 protein subunits assemble to form I <jats:sub>Kslow</jats:sub> channels in the heart and ear. Inherited mutations in either subunit that decrease protein level or alter function can cause life-threatening cardiac arrhythmias and deafness. The mechanism by which E1 slows channel opening has been the subject of active debate. Here, we use gating current measurements and simultaneous recordings of ionic currents and changes in fluorescence of a probe on the Q1 voltage sensors to demonstrate that E1 slows the movement of sensors in a manner that is both necessary and sufficient to determine the slow activation time course of I <jats:sub>Ks</jats:sub> channels. </jats:p> |
| doi_str_mv | 10.1073/pnas.1222616110 |
| facet_avail | Online, Free |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjEyMjI2MTYxMTA |
| imprint | Proceedings of the National Academy of Sciences, 2013 |
| imprint_str_mv | Proceedings of the National Academy of Sciences, 2013 |
| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1 |
| issn | 0027-8424, 1091-6490 |
| issn_str_mv | 0027-8424, 1091-6490 |
| language | English |
| last_indexed | 2024-03-01T17:29:13.63Z |
| match_str | ruscic2013ikschannelsopenslowlybecausekcne1accessorysubunitsslowthemovementofs4voltagesensorsinkcnq1poreformingsubunits |
| mega_collection | Proceedings of the National Academy of Sciences (CrossRef) |
| physical | |
| publishDate | 2013 |
| publishDateSort | 2013 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | ai |
| recordtype | ai |
| series | Proceedings of the National Academy of Sciences |
| source_id | 49 |
| spelling | Ruscic, Katarina J. Miceli, Francesco Villalba-Galea, Carlos A. Dai, Hui Mishina, Yukiko Bezanilla, Francisco Goldstein, Steve A. N. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1222616110 <jats:title>Significance</jats:title> <jats:p> E1 and Q1 protein subunits assemble to form I <jats:sub>Kslow</jats:sub> channels in the heart and ear. Inherited mutations in either subunit that decrease protein level or alter function can cause life-threatening cardiac arrhythmias and deafness. The mechanism by which E1 slows channel opening has been the subject of active debate. Here, we use gating current measurements and simultaneous recordings of ionic currents and changes in fluorescence of a probe on the Q1 voltage sensors to demonstrate that E1 slows the movement of sensors in a manner that is both necessary and sufficient to determine the slow activation time course of I <jats:sub>Ks</jats:sub> channels. </jats:p> I <sub>Ks</sub> channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits Proceedings of the National Academy of Sciences |
| spellingShingle | Ruscic, Katarina J., Miceli, Francesco, Villalba-Galea, Carlos A., Dai, Hui, Mishina, Yukiko, Bezanilla, Francisco, Goldstein, Steve A. N., Proceedings of the National Academy of Sciences, I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits, Multidisciplinary |
| title | I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| title_full | I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| title_fullStr | I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| title_full_unstemmed | I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| title_short | I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| title_sort | i <sub>ks</sub> channels open slowly because kcne1 accessory subunits slow the movement of s4 voltage sensors in kcnq1 pore-forming subunits |
| title_unstemmed | I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1222616110 |