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I Ks channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
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| Personen und Körperschaften: | , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 110, 2013, 7 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| Zusammenfassung: | <jats:title>Significance</jats:title> <jats:p> E1 and Q1 protein subunits assemble to form I <jats:sub>Kslow</jats:sub> channels in the heart and ear. Inherited mutations in either subunit that decrease protein level or alter function can cause life-threatening cardiac arrhythmias and deafness. The mechanism by which E1 slows channel opening has been the subject of active debate. Here, we use gating current measurements and simultaneous recordings of ionic currents and changes in fluorescence of a probe on the Q1 voltage sensors to demonstrate that E1 slows the movement of sensors in a manner that is both necessary and sufficient to determine the slow activation time course of I <jats:sub>Ks</jats:sub> channels. </jats:p> |
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| ISSN: |
0027-8424
1091-6490 |
| DOI: | 10.1073/pnas.1222616110 |