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Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 112, 2015, 42, S. 13115-13120 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| author_facet |
Honkela, Antti Peltonen, Jaakko Topa, Hande Charapitsa, Iryna Matarese, Filomena Grote, Korbinian Stunnenberg, Hendrik G. Reid, George Lawrence, Neil D. Rattray, Magnus Honkela, Antti Peltonen, Jaakko Topa, Hande Charapitsa, Iryna Matarese, Filomena Grote, Korbinian Stunnenberg, Hendrik G. Reid, George Lawrence, Neil D. Rattray, Magnus |
|---|---|
| author |
Honkela, Antti Peltonen, Jaakko Topa, Hande Charapitsa, Iryna Matarese, Filomena Grote, Korbinian Stunnenberg, Hendrik G. Reid, George Lawrence, Neil D. Rattray, Magnus |
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Honkela, Antti Peltonen, Jaakko Topa, Hande Charapitsa, Iryna Matarese, Filomena Grote, Korbinian Stunnenberg, Hendrik G. Reid, George Lawrence, Neil D. Rattray, Magnus Proceedings of the National Academy of Sciences Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays Multidisciplinary |
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Honkela, Antti Peltonen, Jaakko Topa, Hande Charapitsa, Iryna Matarese, Filomena Grote, Korbinian Stunnenberg, Hendrik G. Reid, George Lawrence, Neil D. Rattray, Magnus 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1420404112 <jats:title>Significance</jats:title> <jats:p>Gene transcription is a highly regulated dynamic process. Delays in transcription have important consequences on dynamics of gene expression and consequently on downstream biological function. We model temporal dynamics of transcription using genome-wide time course data measuring transcriptional activity and mRNA concentration. We find a significant number of genes exhibit a long RNA processing delay between transcription termination and mRNA production. These long processing delays are more common for short genes, which would otherwise be expected to transcribe most rapidly. The distribution of intronic reads suggests that these delays are required for splicing to be completed. Understanding such delays is essential for understanding how a rapid cellular response is regulated.</jats:p> Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays Proceedings of the National Academy of Sciences |
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Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
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Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
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Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
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Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
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Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
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Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
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genome-wide modeling of transcription kinetics reveals patterns of rna production delays |
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<jats:title>Significance</jats:title>
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| author | Honkela, Antti, Peltonen, Jaakko, Topa, Hande, Charapitsa, Iryna, Matarese, Filomena, Grote, Korbinian, Stunnenberg, Hendrik G., Reid, George, Lawrence, Neil D., Rattray, Magnus |
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| description | <jats:title>Significance</jats:title> <jats:p>Gene transcription is a highly regulated dynamic process. Delays in transcription have important consequences on dynamics of gene expression and consequently on downstream biological function. We model temporal dynamics of transcription using genome-wide time course data measuring transcriptional activity and mRNA concentration. We find a significant number of genes exhibit a long RNA processing delay between transcription termination and mRNA production. These long processing delays are more common for short genes, which would otherwise be expected to transcribe most rapidly. The distribution of intronic reads suggests that these delays are required for splicing to be completed. Understanding such delays is essential for understanding how a rapid cellular response is regulated.</jats:p> |
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| spelling | Honkela, Antti Peltonen, Jaakko Topa, Hande Charapitsa, Iryna Matarese, Filomena Grote, Korbinian Stunnenberg, Hendrik G. Reid, George Lawrence, Neil D. Rattray, Magnus 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1420404112 <jats:title>Significance</jats:title> <jats:p>Gene transcription is a highly regulated dynamic process. Delays in transcription have important consequences on dynamics of gene expression and consequently on downstream biological function. We model temporal dynamics of transcription using genome-wide time course data measuring transcriptional activity and mRNA concentration. We find a significant number of genes exhibit a long RNA processing delay between transcription termination and mRNA production. These long processing delays are more common for short genes, which would otherwise be expected to transcribe most rapidly. The distribution of intronic reads suggests that these delays are required for splicing to be completed. Understanding such delays is essential for understanding how a rapid cellular response is regulated.</jats:p> Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays Proceedings of the National Academy of Sciences |
| spellingShingle | Honkela, Antti, Peltonen, Jaakko, Topa, Hande, Charapitsa, Iryna, Matarese, Filomena, Grote, Korbinian, Stunnenberg, Hendrik G., Reid, George, Lawrence, Neil D., Rattray, Magnus, Proceedings of the National Academy of Sciences, Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays, Multidisciplinary |
| title | Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
| title_full | Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
| title_fullStr | Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
| title_full_unstemmed | Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
| title_short | Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
| title_sort | genome-wide modeling of transcription kinetics reveals patterns of rna production delays |
| title_unstemmed | Genome-wide modeling of transcription kinetics reveals patterns of RNA production delays |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1420404112 |