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Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 111, 2014, 30, S. 11121-11126 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| author_facet |
Santagata, Sandro Eberlin, Livia S. Norton, Isaiah Calligaris, David Feldman, Daniel R. Ide, Jennifer L. Liu, Xiaohui Wiley, Joshua S. Vestal, Matthew L. Ramkissoon, Shakti H. Orringer, Daniel A. Gill, Kristen K. Dunn, Ian F. Dias-Santagata, Dora Ligon, Keith L. Jolesz, Ferenc A. Golby, Alexandra J. Cooks, R. Graham Agar, Nathalie Y. R. Santagata, Sandro Eberlin, Livia S. Norton, Isaiah Calligaris, David Feldman, Daniel R. Ide, Jennifer L. Liu, Xiaohui Wiley, Joshua S. Vestal, Matthew L. Ramkissoon, Shakti H. Orringer, Daniel A. Gill, Kristen K. Dunn, Ian F. Dias-Santagata, Dora Ligon, Keith L. Jolesz, Ferenc A. Golby, Alexandra J. Cooks, R. Graham Agar, Nathalie Y. R. |
|---|---|
| author |
Santagata, Sandro Eberlin, Livia S. Norton, Isaiah Calligaris, David Feldman, Daniel R. Ide, Jennifer L. Liu, Xiaohui Wiley, Joshua S. Vestal, Matthew L. Ramkissoon, Shakti H. Orringer, Daniel A. Gill, Kristen K. Dunn, Ian F. Dias-Santagata, Dora Ligon, Keith L. Jolesz, Ferenc A. Golby, Alexandra J. Cooks, R. Graham Agar, Nathalie Y. R. |
| spellingShingle |
Santagata, Sandro Eberlin, Livia S. Norton, Isaiah Calligaris, David Feldman, Daniel R. Ide, Jennifer L. Liu, Xiaohui Wiley, Joshua S. Vestal, Matthew L. Ramkissoon, Shakti H. Orringer, Daniel A. Gill, Kristen K. Dunn, Ian F. Dias-Santagata, Dora Ligon, Keith L. Jolesz, Ferenc A. Golby, Alexandra J. Cooks, R. Graham Agar, Nathalie Y. R. Proceedings of the National Academy of Sciences Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery Multidisciplinary |
| author_sort |
santagata, sandro |
| spelling |
Santagata, Sandro Eberlin, Livia S. Norton, Isaiah Calligaris, David Feldman, Daniel R. Ide, Jennifer L. Liu, Xiaohui Wiley, Joshua S. Vestal, Matthew L. Ramkissoon, Shakti H. Orringer, Daniel A. Gill, Kristen K. Dunn, Ian F. Dias-Santagata, Dora Ligon, Keith L. Jolesz, Ferenc A. Golby, Alexandra J. Cooks, R. Graham Agar, Nathalie Y. R. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1404724111 <jats:title>Significance</jats:title> <jats:p>The diagnosis of tumors during surgery still relies principally on an approach developed over 150 y ago: frozen section microscopy. We show that a validated molecular marker—2-hydroxyglutarate generated from isocitrate dehydrogenase 1 mutant gliomas—can be rapidly detected from tumors using a form of ambient MS that does not require sample preparation. We use the Advanced Multimodality Image Guided Operating Suite at Brigham and Women’s Hospital to demonstrate that desorption electrospray ionization MS could be used to detect residual tumor that would have been left behind in the patient. The approach paves the way for the clinical testing of MS-based intraoperative monitoring of tumor metabolites, an advance that could revolutionize the care of surgical oncology patients.</jats:p> Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery Proceedings of the National Academy of Sciences |
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| title |
Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| title_unstemmed |
Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| title_full |
Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
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Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| title_full_unstemmed |
Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| title_short |
Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| title_sort |
intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
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Multidisciplinary |
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http://dx.doi.org/10.1073/pnas.1404724111 |
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2014 |
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11121-11126 |
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<jats:title>Significance</jats:title>
<jats:p>The diagnosis of tumors during surgery still relies principally on an approach developed over 150 y ago: frozen section microscopy. We show that a validated molecular marker—2-hydroxyglutarate generated from isocitrate dehydrogenase 1 mutant gliomas—can be rapidly detected from tumors using a form of ambient MS that does not require sample preparation. We use the Advanced Multimodality Image Guided Operating Suite at Brigham and Women’s Hospital to demonstrate that desorption electrospray ionization MS could be used to detect residual tumor that would have been left behind in the patient. The approach paves the way for the clinical testing of MS-based intraoperative monitoring of tumor metabolites, an advance that could revolutionize the care of surgical oncology patients.</jats:p> |
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| author | Santagata, Sandro, Eberlin, Livia S., Norton, Isaiah, Calligaris, David, Feldman, Daniel R., Ide, Jennifer L., Liu, Xiaohui, Wiley, Joshua S., Vestal, Matthew L., Ramkissoon, Shakti H., Orringer, Daniel A., Gill, Kristen K., Dunn, Ian F., Dias-Santagata, Dora, Ligon, Keith L., Jolesz, Ferenc A., Golby, Alexandra J., Cooks, R. Graham, Agar, Nathalie Y. R. |
| author_facet | Santagata, Sandro, Eberlin, Livia S., Norton, Isaiah, Calligaris, David, Feldman, Daniel R., Ide, Jennifer L., Liu, Xiaohui, Wiley, Joshua S., Vestal, Matthew L., Ramkissoon, Shakti H., Orringer, Daniel A., Gill, Kristen K., Dunn, Ian F., Dias-Santagata, Dora, Ligon, Keith L., Jolesz, Ferenc A., Golby, Alexandra J., Cooks, R. Graham, Agar, Nathalie Y. R., Santagata, Sandro, Eberlin, Livia S., Norton, Isaiah, Calligaris, David, Feldman, Daniel R., Ide, Jennifer L., Liu, Xiaohui, Wiley, Joshua S., Vestal, Matthew L., Ramkissoon, Shakti H., Orringer, Daniel A., Gill, Kristen K., Dunn, Ian F., Dias-Santagata, Dora, Ligon, Keith L., Jolesz, Ferenc A., Golby, Alexandra J., Cooks, R. Graham, Agar, Nathalie Y. R. |
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| description | <jats:title>Significance</jats:title> <jats:p>The diagnosis of tumors during surgery still relies principally on an approach developed over 150 y ago: frozen section microscopy. We show that a validated molecular marker—2-hydroxyglutarate generated from isocitrate dehydrogenase 1 mutant gliomas—can be rapidly detected from tumors using a form of ambient MS that does not require sample preparation. We use the Advanced Multimodality Image Guided Operating Suite at Brigham and Women’s Hospital to demonstrate that desorption electrospray ionization MS could be used to detect residual tumor that would have been left behind in the patient. The approach paves the way for the clinical testing of MS-based intraoperative monitoring of tumor metabolites, an advance that could revolutionize the care of surgical oncology patients.</jats:p> |
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| spelling | Santagata, Sandro Eberlin, Livia S. Norton, Isaiah Calligaris, David Feldman, Daniel R. Ide, Jennifer L. Liu, Xiaohui Wiley, Joshua S. Vestal, Matthew L. Ramkissoon, Shakti H. Orringer, Daniel A. Gill, Kristen K. Dunn, Ian F. Dias-Santagata, Dora Ligon, Keith L. Jolesz, Ferenc A. Golby, Alexandra J. Cooks, R. Graham Agar, Nathalie Y. R. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1404724111 <jats:title>Significance</jats:title> <jats:p>The diagnosis of tumors during surgery still relies principally on an approach developed over 150 y ago: frozen section microscopy. We show that a validated molecular marker—2-hydroxyglutarate generated from isocitrate dehydrogenase 1 mutant gliomas—can be rapidly detected from tumors using a form of ambient MS that does not require sample preparation. We use the Advanced Multimodality Image Guided Operating Suite at Brigham and Women’s Hospital to demonstrate that desorption electrospray ionization MS could be used to detect residual tumor that would have been left behind in the patient. The approach paves the way for the clinical testing of MS-based intraoperative monitoring of tumor metabolites, an advance that could revolutionize the care of surgical oncology patients.</jats:p> Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery Proceedings of the National Academy of Sciences |
| spellingShingle | Santagata, Sandro, Eberlin, Livia S., Norton, Isaiah, Calligaris, David, Feldman, Daniel R., Ide, Jennifer L., Liu, Xiaohui, Wiley, Joshua S., Vestal, Matthew L., Ramkissoon, Shakti H., Orringer, Daniel A., Gill, Kristen K., Dunn, Ian F., Dias-Santagata, Dora, Ligon, Keith L., Jolesz, Ferenc A., Golby, Alexandra J., Cooks, R. Graham, Agar, Nathalie Y. R., Proceedings of the National Academy of Sciences, Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery, Multidisciplinary |
| title | Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| title_full | Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| title_fullStr | Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| title_full_unstemmed | Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| title_short | Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| title_sort | intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| title_unstemmed | Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1404724111 |