Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery

Gespeichert in:

Bibliographische Detailangaben
Zeitschriftentitel:	Proceedings of the National Academy of Sciences
Personen und Körperschaften:	Santagata, Sandro, Eberlin, Livia S., Norton, Isaiah, Calligaris, David, Feldman, Daniel R., Ide, Jennifer L., Liu, Xiaohui, Wiley, Joshua S., Vestal, Matthew L., Ramkissoon, Shakti H., Orringer, Daniel A., Gill, Kristen K., Dunn, Ian F., Dias-Santagata, Dora, Ligon, Keith L., Jolesz, Ferenc A., Golby, Alexandra J., Cooks, R. Graham, Agar, Nathalie Y. R.
In:	Proceedings of the National Academy of Sciences, 111, 2014, 30, S. 11121-11126
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Proceedings of the National Academy of Sciences
Schlagwörter:	Multidisciplinary

Details
Zusammenfassung:	<jats:title>Significance</jats:title> <jats:p>The diagnosis of tumors during surgery still relies principally on an approach developed over 150 y ago: frozen section microscopy. We show that a validated molecular marker—2-hydroxyglutarate generated from isocitrate dehydrogenase 1 mutant gliomas—can be rapidly detected from tumors using a form of ambient MS that does not require sample preparation. We use the Advanced Multimodality Image Guided Operating Suite at Brigham and Women’s Hospital to demonstrate that desorption electrospray ionization MS could be used to detect residual tumor that would have been left behind in the patient. The approach paves the way for the clinical testing of MS-based intraoperative monitoring of tumor metabolites, an advance that could revolutionize the care of surgical oncology patients.</jats:p>
Umfang:	11121-11126
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.1404724111