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Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
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| Personen und Körperschaften: | , , , , , , , , , , , , , |
| In: | Proceedings of the National Academy of Sciences, 111, 2014, 14 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| author_facet |
Nociari, Marcelo M. Lehmann, Guillermo L. Perez Bay, Andres E. Radu, Roxana A. Jiang, Zhichun Goicochea, Shelby Schreiner, Ryan Warren, J. David Shan, Jufang Adam de Beaumais, Ségolène Ménand, Mickaël Sollogoub, Matthieu Maxfield, Frederick R. Rodriguez-Boulan, Enrique Nociari, Marcelo M. Lehmann, Guillermo L. Perez Bay, Andres E. Radu, Roxana A. Jiang, Zhichun Goicochea, Shelby Schreiner, Ryan Warren, J. David Shan, Jufang Adam de Beaumais, Ségolène Ménand, Mickaël Sollogoub, Matthieu Maxfield, Frederick R. Rodriguez-Boulan, Enrique |
|---|---|
| author |
Nociari, Marcelo M. Lehmann, Guillermo L. Perez Bay, Andres E. Radu, Roxana A. Jiang, Zhichun Goicochea, Shelby Schreiner, Ryan Warren, J. David Shan, Jufang Adam de Beaumais, Ségolène Ménand, Mickaël Sollogoub, Matthieu Maxfield, Frederick R. Rodriguez-Boulan, Enrique |
| spellingShingle |
Nociari, Marcelo M. Lehmann, Guillermo L. Perez Bay, Andres E. Radu, Roxana A. Jiang, Zhichun Goicochea, Shelby Schreiner, Ryan Warren, J. David Shan, Jufang Adam de Beaumais, Ségolène Ménand, Mickaël Sollogoub, Matthieu Maxfield, Frederick R. Rodriguez-Boulan, Enrique Proceedings of the National Academy of Sciences Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium Multidisciplinary |
| author_sort |
nociari, marcelo m. |
| spelling |
Nociari, Marcelo M. Lehmann, Guillermo L. Perez Bay, Andres E. Radu, Roxana A. Jiang, Zhichun Goicochea, Shelby Schreiner, Ryan Warren, J. David Shan, Jufang Adam de Beaumais, Ségolène Ménand, Mickaël Sollogoub, Matthieu Maxfield, Frederick R. Rodriguez-Boulan, Enrique 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1400530111 <jats:title>Significance</jats:title> <jats:p>Lipofuscin accumulation in the retinal pigment epithelium (RPE) is a hallmark of aging. High lipofuscin levels in the RPE have been associated with retinal degeneration and blindness in Stargardt disease patients and animal models. Currently, there is no treatment to prevent and/or revert lipofuscin-driven retinal degenerative changes. In this study, we report that beta cyclodextrins, cyclic sugars composed of seven glucose units, can bind retinal lipofuscin, prevent its oxidation and remove it from RPE. This study opens an avenue to develop small drugs against, currently untreatable, lipofuscin-associated blinding disorders.</jats:p> Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium Proceedings of the National Academy of Sciences |
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| title |
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_unstemmed |
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_full |
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_fullStr |
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_full_unstemmed |
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_short |
Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_sort |
beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
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Multidisciplinary |
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http://dx.doi.org/10.1073/pnas.1400530111 |
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2014 |
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|
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<jats:title>Significance</jats:title>
<jats:p>Lipofuscin accumulation in the retinal pigment epithelium (RPE) is a hallmark of aging. High lipofuscin levels in the RPE have been associated with retinal degeneration and blindness in Stargardt disease patients and animal models. Currently, there is no treatment to prevent and/or revert lipofuscin-driven retinal degenerative changes. In this study, we report that beta cyclodextrins, cyclic sugars composed of seven glucose units, can bind retinal lipofuscin, prevent its oxidation and remove it from RPE. This study opens an avenue to develop small drugs against, currently untreatable, lipofuscin-associated blinding disorders.</jats:p> |
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| author | Nociari, Marcelo M., Lehmann, Guillermo L., Perez Bay, Andres E., Radu, Roxana A., Jiang, Zhichun, Goicochea, Shelby, Schreiner, Ryan, Warren, J. David, Shan, Jufang, Adam de Beaumais, Ségolène, Ménand, Mickaël, Sollogoub, Matthieu, Maxfield, Frederick R., Rodriguez-Boulan, Enrique |
| author_facet | Nociari, Marcelo M., Lehmann, Guillermo L., Perez Bay, Andres E., Radu, Roxana A., Jiang, Zhichun, Goicochea, Shelby, Schreiner, Ryan, Warren, J. David, Shan, Jufang, Adam de Beaumais, Ségolène, Ménand, Mickaël, Sollogoub, Matthieu, Maxfield, Frederick R., Rodriguez-Boulan, Enrique, Nociari, Marcelo M., Lehmann, Guillermo L., Perez Bay, Andres E., Radu, Roxana A., Jiang, Zhichun, Goicochea, Shelby, Schreiner, Ryan, Warren, J. David, Shan, Jufang, Adam de Beaumais, Ségolène, Ménand, Mickaël, Sollogoub, Matthieu, Maxfield, Frederick R., Rodriguez-Boulan, Enrique |
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| description | <jats:title>Significance</jats:title> <jats:p>Lipofuscin accumulation in the retinal pigment epithelium (RPE) is a hallmark of aging. High lipofuscin levels in the RPE have been associated with retinal degeneration and blindness in Stargardt disease patients and animal models. Currently, there is no treatment to prevent and/or revert lipofuscin-driven retinal degenerative changes. In this study, we report that beta cyclodextrins, cyclic sugars composed of seven glucose units, can bind retinal lipofuscin, prevent its oxidation and remove it from RPE. This study opens an avenue to develop small drugs against, currently untreatable, lipofuscin-associated blinding disorders.</jats:p> |
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| spelling | Nociari, Marcelo M. Lehmann, Guillermo L. Perez Bay, Andres E. Radu, Roxana A. Jiang, Zhichun Goicochea, Shelby Schreiner, Ryan Warren, J. David Shan, Jufang Adam de Beaumais, Ségolène Ménand, Mickaël Sollogoub, Matthieu Maxfield, Frederick R. Rodriguez-Boulan, Enrique 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.1400530111 <jats:title>Significance</jats:title> <jats:p>Lipofuscin accumulation in the retinal pigment epithelium (RPE) is a hallmark of aging. High lipofuscin levels in the RPE have been associated with retinal degeneration and blindness in Stargardt disease patients and animal models. Currently, there is no treatment to prevent and/or revert lipofuscin-driven retinal degenerative changes. In this study, we report that beta cyclodextrins, cyclic sugars composed of seven glucose units, can bind retinal lipofuscin, prevent its oxidation and remove it from RPE. This study opens an avenue to develop small drugs against, currently untreatable, lipofuscin-associated blinding disorders.</jats:p> Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium Proceedings of the National Academy of Sciences |
| spellingShingle | Nociari, Marcelo M., Lehmann, Guillermo L., Perez Bay, Andres E., Radu, Roxana A., Jiang, Zhichun, Goicochea, Shelby, Schreiner, Ryan, Warren, J. David, Shan, Jufang, Adam de Beaumais, Ségolène, Ménand, Mickaël, Sollogoub, Matthieu, Maxfield, Frederick R., Rodriguez-Boulan, Enrique, Proceedings of the National Academy of Sciences, Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium, Multidisciplinary |
| title | Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_full | Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_fullStr | Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_full_unstemmed | Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_short | Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_sort | beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| title_unstemmed | Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium |
| topic | Multidisciplinary |
| url | http://dx.doi.org/10.1073/pnas.1400530111 |