Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium

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Bibliographische Detailangaben
Zeitschriftentitel:	Proceedings of the National Academy of Sciences
Personen und Körperschaften:	Nociari, Marcelo M., Lehmann, Guillermo L., Perez Bay, Andres E., Radu, Roxana A., Jiang, Zhichun, Goicochea, Shelby, Schreiner, Ryan, Warren, J. David, Shan, Jufang, Adam de Beaumais, Ségolène, Ménand, Mickaël, Sollogoub, Matthieu, Maxfield, Frederick R., Rodriguez-Boulan, Enrique
In:	Proceedings of the National Academy of Sciences, 111, 2014, 14
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	Proceedings of the National Academy of Sciences
Schlagwörter:	Multidisciplinary

Details
Zusammenfassung:	<jats:title>Significance</jats:title> <jats:p>Lipofuscin accumulation in the retinal pigment epithelium (RPE) is a hallmark of aging. High lipofuscin levels in the RPE have been associated with retinal degeneration and blindness in Stargardt disease patients and animal models. Currently, there is no treatment to prevent and/or revert lipofuscin-driven retinal degenerative changes. In this study, we report that beta cyclodextrins, cyclic sugars composed of seven glucose units, can bind retinal lipofuscin, prevent its oxidation and remove it from RPE. This study opens an avenue to develop small drugs against, currently untreatable, lipofuscin-associated blinding disorders.</jats:p>
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.1400530111