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IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain
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| Zeitschriftentitel: | Journal of Neurochemistry |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Journal of Neurochemistry, 85, 2003, s2, S. 28-28 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Adamo, E. B. Marini, H. Marini, R. Bellomo, M. Altavilla, D. Calapai, G. Bitto, A. Squadrito, F. Adamo, E. B. Marini, H. Marini, R. Bellomo, M. Altavilla, D. Calapai, G. Bitto, A. Squadrito, F. |
|---|---|
| author |
Adamo, E. B. Marini, H. Marini, R. Bellomo, M. Altavilla, D. Calapai, G. Bitto, A. Squadrito, F. |
| spellingShingle |
Adamo, E. B. Marini, H. Marini, R. Bellomo, M. Altavilla, D. Calapai, G. Bitto, A. Squadrito, F. Journal of Neurochemistry IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain Cellular and Molecular Neuroscience Biochemistry |
| author_sort |
adamo, e. b. |
| spelling |
Adamo, E. B. Marini, H. Marini, R. Bellomo, M. Altavilla, D. Calapai, G. Bitto, A. Squadrito, F. 0022-3042 1471-4159 Wiley Cellular and Molecular Neuroscience Biochemistry http://dx.doi.org/10.1046/j.1471-4159.85.s2.19_1.x <jats:p>We investigated if IRFI 042, an analog of vitamin E, protects the brain against oxidative stress induced by intraperitoneal administration of Kainic acid (KA) (10 mg/kg); sham brain injury rats were used as controls. Animals received either IRFI 042 (20 mg/kg) or its vehicle 30 min before KA injection and after 6 h were sacrificed to measure malonildyaldheide (MDA) and glutathione levels (GSH) in the diencephalon. Behavioral changes were also monitored. Intraperitoneal administration of IRFI decreased MDA (micromol/g wet tissue: KA + vehicle = 22.5 ± 4.2; KA + IRFI = 17.1 ± 1; <jats:italic>P</jats:italic> < 0.005) and prevented GSH loss (nmol/g wet tissue: KA + vehicle = 0.41 ± 0.1; KA + IRFI = 1.86 ± 0.2; <jats:italic>P</jats:italic> < 0.005) in the diencephalon. The latency of occurrence of behavioral signs increased from 39 ± 1 to 62 ± 6 min in IRFI 042 group. The data suggest that IRFI 042 might protect against KA‐induced oxidative stress.</jats:p> IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain Journal of Neurochemistry |
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10.1046/j.1471-4159.85.s2.19_1.x |
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Online Free |
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Chemie und Pharmazie Biologie Psychologie |
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Wiley, 2003 |
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Wiley, 2003 |
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0022-3042 1471-4159 |
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Journal of Neurochemistry |
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| title |
IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_unstemmed |
IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_full |
IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_fullStr |
IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_full_unstemmed |
IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_short |
IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_sort |
irfi 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| topic |
Cellular and Molecular Neuroscience Biochemistry |
| url |
http://dx.doi.org/10.1046/j.1471-4159.85.s2.19_1.x |
| publishDate |
2003 |
| physical |
28-28 |
| description |
<jats:p>We investigated if IRFI 042, an analog of vitamin E, protects the brain against oxidative stress induced by intraperitoneal administration of Kainic acid (KA) (10 mg/kg); sham brain injury rats were used as controls. Animals received either IRFI 042 (20 mg/kg) or its vehicle 30 min before KA injection and after 6 h were sacrificed to measure malonildyaldheide (MDA) and glutathione levels (GSH) in the diencephalon. Behavioral changes were also monitored. Intraperitoneal administration of IRFI decreased MDA (micromol/g wet tissue: KA + vehicle = 22.5 ± 4.2; KA + IRFI = 17.1 ± 1; <jats:italic>P</jats:italic> < 0.005) and prevented GSH loss (nmol/g wet tissue: KA + vehicle = 0.41 ± 0.1; KA + IRFI = 1.86 ± 0.2; <jats:italic>P</jats:italic> < 0.005) in the diencephalon. The latency of occurrence of behavioral signs increased from 39 ± 1 to 62 ± 6 min in IRFI 042 group. The data suggest that IRFI 042 might protect against KA‐induced oxidative stress.</jats:p> |
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| author | Adamo, E. B., Marini, H., Marini, R., Bellomo, M., Altavilla, D., Calapai, G., Bitto, A., Squadrito, F. |
| author_facet | Adamo, E. B., Marini, H., Marini, R., Bellomo, M., Altavilla, D., Calapai, G., Bitto, A., Squadrito, F., Adamo, E. B., Marini, H., Marini, R., Bellomo, M., Altavilla, D., Calapai, G., Bitto, A., Squadrito, F. |
| author_sort | adamo, e. b. |
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| description | <jats:p>We investigated if IRFI 042, an analog of vitamin E, protects the brain against oxidative stress induced by intraperitoneal administration of Kainic acid (KA) (10 mg/kg); sham brain injury rats were used as controls. Animals received either IRFI 042 (20 mg/kg) or its vehicle 30 min before KA injection and after 6 h were sacrificed to measure malonildyaldheide (MDA) and glutathione levels (GSH) in the diencephalon. Behavioral changes were also monitored. Intraperitoneal administration of IRFI decreased MDA (micromol/g wet tissue: KA + vehicle = 22.5 ± 4.2; KA + IRFI = 17.1 ± 1; <jats:italic>P</jats:italic> < 0.005) and prevented GSH loss (nmol/g wet tissue: KA + vehicle = 0.41 ± 0.1; KA + IRFI = 1.86 ± 0.2; <jats:italic>P</jats:italic> < 0.005) in the diencephalon. The latency of occurrence of behavioral signs increased from 39 ± 1 to 62 ± 6 min in IRFI 042 group. The data suggest that IRFI 042 might protect against KA‐induced oxidative stress.</jats:p> |
| doi_str_mv | 10.1046/j.1471-4159.85.s2.19_1.x |
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| imprint_str_mv | Wiley, 2003 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 28-28 |
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| spelling | Adamo, E. B. Marini, H. Marini, R. Bellomo, M. Altavilla, D. Calapai, G. Bitto, A. Squadrito, F. 0022-3042 1471-4159 Wiley Cellular and Molecular Neuroscience Biochemistry http://dx.doi.org/10.1046/j.1471-4159.85.s2.19_1.x <jats:p>We investigated if IRFI 042, an analog of vitamin E, protects the brain against oxidative stress induced by intraperitoneal administration of Kainic acid (KA) (10 mg/kg); sham brain injury rats were used as controls. Animals received either IRFI 042 (20 mg/kg) or its vehicle 30 min before KA injection and after 6 h were sacrificed to measure malonildyaldheide (MDA) and glutathione levels (GSH) in the diencephalon. Behavioral changes were also monitored. Intraperitoneal administration of IRFI decreased MDA (micromol/g wet tissue: KA + vehicle = 22.5 ± 4.2; KA + IRFI = 17.1 ± 1; <jats:italic>P</jats:italic> < 0.005) and prevented GSH loss (nmol/g wet tissue: KA + vehicle = 0.41 ± 0.1; KA + IRFI = 1.86 ± 0.2; <jats:italic>P</jats:italic> < 0.005) in the diencephalon. The latency of occurrence of behavioral signs increased from 39 ± 1 to 62 ± 6 min in IRFI 042 group. The data suggest that IRFI 042 might protect against KA‐induced oxidative stress.</jats:p> IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain Journal of Neurochemistry |
| spellingShingle | Adamo, E. B., Marini, H., Marini, R., Bellomo, M., Altavilla, D., Calapai, G., Bitto, A., Squadrito, F., Journal of Neurochemistry, IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain, Cellular and Molecular Neuroscience, Biochemistry |
| title | IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_full | IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_fullStr | IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_full_unstemmed | IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_short | IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_sort | irfi 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| title_unstemmed | IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain |
| topic | Cellular and Molecular Neuroscience, Biochemistry |
| url | http://dx.doi.org/10.1046/j.1471-4159.85.s2.19_1.x |