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IRFI 042 reduces oxidative stress against kainic acid toxicity in the rat brain
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| Zeitschriftentitel: | Journal of Neurochemistry |
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| Personen und Körperschaften: | , , , , , , , |
| In: | Journal of Neurochemistry, 85, 2003, s2, S. 28-28 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| Zusammenfassung: | <jats:p>We investigated if IRFI 042, an analog of vitamin E, protects the brain against oxidative stress induced by intraperitoneal administration of Kainic acid (KA) (10 mg/kg); sham brain injury rats were used as controls. Animals received either IRFI 042 (20 mg/kg) or its vehicle 30 min before KA injection and after 6 h were sacrificed to measure malonildyaldheide (MDA) and glutathione levels (GSH) in the diencephalon. Behavioral changes were also monitored. Intraperitoneal administration of IRFI decreased MDA (micromol/g wet tissue: KA + vehicle = 22.5 ± 4.2; KA + IRFI = 17.1 ± 1; <jats:italic>P</jats:italic> < 0.005) and prevented GSH loss (nmol/g wet tissue: KA + vehicle = 0.41 ± 0.1; KA + IRFI = 1.86 ± 0.2; <jats:italic>P</jats:italic> < 0.005) in the diencephalon. The latency of occurrence of behavioral signs increased from 39 ± 1 to 62 ± 6 min in IRFI 042 group. The data suggest that IRFI 042 might protect against KA‐induced oxidative stress.</jats:p> |
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| Umfang: | 28-28 |
| ISSN: |
0022-3042
1471-4159 |
| DOI: | 10.1046/j.1471-4159.85.s2.19_1.x |