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Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition
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| Zeitschriftentitel: | Biochemical Journal |
|---|---|
| Personen und Körperschaften: | , |
| In: | Biochemical Journal, 271, 1990, 2, S. 523-528 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Boyer, B Odessey, R Boyer, B Odessey, R |
|---|---|
| author |
Boyer, B Odessey, R |
| spellingShingle |
Boyer, B Odessey, R Biochemical Journal Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition Cell Biology Molecular Biology Biochemistry |
| author_sort |
boyer, b |
| spelling |
Boyer, B Odessey, R 0264-6021 1470-8728 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj2710523 <jats:p>The potential for branched-chain 2-oxo acid dehydrogenase complex (BCOADC) activity to be controlled by feedback inhibition was investigated by calculating the Elasticity Coefficients for several feedback inhibitors. We suggest that feedback inhibition is a quantitatively important regulatory mechanism by which branched-chain 2-oxo acid dehydrogenase activity is regulated. The potential for control of enzyme activity is greater for NADH than for the acyl-CoA products, and suggests that factors that alter the redox potential may physiologically regulate BCOADC activity through a feedback inhibitory mechanism in vivo. Local pH may also be an important regulatory control factor.</jats:p> Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition Biochemical Journal |
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Portland Press Ltd., 1990 |
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Portland Press Ltd., 1990 |
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0264-6021 1470-8728 |
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0264-6021 1470-8728 |
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1990 |
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Biochemical Journal |
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49 |
| title |
Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_unstemmed |
Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_full |
Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_fullStr |
Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_full_unstemmed |
Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_short |
Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_sort |
quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| topic |
Cell Biology Molecular Biology Biochemistry |
| url |
http://dx.doi.org/10.1042/bj2710523 |
| publishDate |
1990 |
| physical |
523-528 |
| description |
<jats:p>The potential for branched-chain 2-oxo acid dehydrogenase complex (BCOADC) activity to be controlled by feedback inhibition was investigated by calculating the Elasticity Coefficients for several feedback inhibitors. We suggest that feedback inhibition is a quantitatively important regulatory mechanism by which branched-chain 2-oxo acid dehydrogenase activity is regulated. The potential for control of enzyme activity is greater for NADH than for the acyl-CoA products, and suggests that factors that alter the redox potential may physiologically regulate BCOADC activity through a feedback inhibitory mechanism in vivo. Local pH may also be an important regulatory control factor.</jats:p> |
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| author | Boyer, B, Odessey, R |
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| author_sort | boyer, b |
| container_issue | 2 |
| container_start_page | 523 |
| container_title | Biochemical Journal |
| container_volume | 271 |
| description | <jats:p>The potential for branched-chain 2-oxo acid dehydrogenase complex (BCOADC) activity to be controlled by feedback inhibition was investigated by calculating the Elasticity Coefficients for several feedback inhibitors. We suggest that feedback inhibition is a quantitatively important regulatory mechanism by which branched-chain 2-oxo acid dehydrogenase activity is regulated. The potential for control of enzyme activity is greater for NADH than for the acyl-CoA products, and suggests that factors that alter the redox potential may physiologically regulate BCOADC activity through a feedback inhibitory mechanism in vivo. Local pH may also be an important regulatory control factor.</jats:p> |
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| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA0Mi9iajI3MTA1MjM |
| imprint | Portland Press Ltd., 1990 |
| imprint_str_mv | Portland Press Ltd., 1990 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
| issn | 0264-6021, 1470-8728 |
| issn_str_mv | 0264-6021, 1470-8728 |
| language | English |
| last_indexed | 2024-03-01T18:10:43.108Z |
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| mega_collection | Portland Press Ltd. (CrossRef) |
| physical | 523-528 |
| publishDate | 1990 |
| publishDateSort | 1990 |
| publisher | Portland Press Ltd. |
| record_format | ai |
| recordtype | ai |
| series | Biochemical Journal |
| source_id | 49 |
| spelling | Boyer, B Odessey, R 0264-6021 1470-8728 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj2710523 <jats:p>The potential for branched-chain 2-oxo acid dehydrogenase complex (BCOADC) activity to be controlled by feedback inhibition was investigated by calculating the Elasticity Coefficients for several feedback inhibitors. We suggest that feedback inhibition is a quantitatively important regulatory mechanism by which branched-chain 2-oxo acid dehydrogenase activity is regulated. The potential for control of enzyme activity is greater for NADH than for the acyl-CoA products, and suggests that factors that alter the redox potential may physiologically regulate BCOADC activity through a feedback inhibitory mechanism in vivo. Local pH may also be an important regulatory control factor.</jats:p> Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition Biochemical Journal |
| spellingShingle | Boyer, B, Odessey, R, Biochemical Journal, Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition, Cell Biology, Molecular Biology, Biochemistry |
| title | Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_full | Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_fullStr | Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_full_unstemmed | Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_short | Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_sort | quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| title_unstemmed | Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition |
| topic | Cell Biology, Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.1042/bj2710523 |