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Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition
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| Zeitschriftentitel: | Biochemical Journal |
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| Personen und Körperschaften: | , |
| In: | Biochemical Journal, 271, 1990, 2, S. 523-528 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
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| Schlagwörter: |
| Zusammenfassung: | <jats:p>The potential for branched-chain 2-oxo acid dehydrogenase complex (BCOADC) activity to be controlled by feedback inhibition was investigated by calculating the Elasticity Coefficients for several feedback inhibitors. We suggest that feedback inhibition is a quantitatively important regulatory mechanism by which branched-chain 2-oxo acid dehydrogenase activity is regulated. The potential for control of enzyme activity is greater for NADH than for the acyl-CoA products, and suggests that factors that alter the redox potential may physiologically regulate BCOADC activity through a feedback inhibitory mechanism in vivo. Local pH may also be an important regulatory control factor.</jats:p> |
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| Umfang: | 523-528 |
| ISSN: |
0264-6021
1470-8728 |
| DOI: | 10.1042/bj2710523 |