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Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder: first evidence from the South Eastern Europe (SEE)-PTSD study
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| Veröffentlicht in: | The international journal of neuropsychopharmacology 21, 5 (2018), 423–432 |
|---|---|
| Personen und Körperschaften: | , , |
| Titel: | Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder: first evidence from the South Eastern Europe (SEE)-PTSD study/ Christiane Ziegler, Miriam A. Schiele, Katharina Domschke |
| Format: | E-Book Sonderdruck |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge
Univ. Press
2017
Freiburg Albert-Ludwigs-Universität Freiburg 2021 |
| Gesamtaufnahme: |
Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder; 21, 5 (2018), 423–432
|
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder |b first evidence from the South Eastern Europe (SEE)-PTSD study |c Christiane Ziegler, Miriam A. Schiele, Katharina Domschke |
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| 520 | |a Abstract: Background: Posttraumatic stress disorder is characterized by an overactive noradrenergic system conferring core posttraumatic stress disorder symptoms such as hyperarousal and reexperiencing. Monoamine oxidase A is one of the key enzymes mediating the turnover of noradrenaline. Here, DNA methylation of the monoamine oxidase A gene exonI/intronI region was investigated for the first time regarding its role in posttraumatic stress disorder risk and severity.Methods: Monoamine oxidase A methylation was analyzed via direct sequencing of sodium bisulfite-treated DNA extracted from blood cells in a total sample of N = 652 ( 441 male) patients with current posttraumatic stress disorder, patients with remitted posttraumatic stress disorder, and healthy probands (comparison group) recruited at 5 centers in Bosnia-Herzegovina, Croatia, and the Republic of Kosovo. Posttraumatic stress disorder severity was measured by means of the Clinician-Administered Posttraumatic Stress Disorder Scale and its respective subscores representing distinct symptom clusters.Results: In the male, but not the female sample, patients with current posttraumatic stress disorder displayed hypermethylation of 3 CpGs (CpG3 = 43 656 362; CpG12 = 43 656 514; CpG13 = 43 656 553, GRCh38.p2 Assembly) as compared with remitted Posttraumatic Stress Disorder patients and healthy probands. Symptom severity (Clinician-Administered Posttraumatic Stress Disorder Scale scores) in male patients with current posttraumatic stress disorder significantly correlated with monoamine oxidase A methylation. This applied particularly to symptom clusters related to reexperiencing of trauma (cluster B) and hyperarousal (cluster D).Conclusions: The present findings suggest monoamine oxidase A gene hypermethylation, potentially resulting in enhanced noradrenergic signalling, as a disease status and severity marker of current posttraumatic stress disorder in males. If replicated, monoamine oxidase A hypermethylation might serve as a surrogate marker of a hyperadrenergic subtype of posttraumatic stress disorder guiding personalized treatment decisions on the use of antiadrenergic agents | ||
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| contents | Abstract: Background: Posttraumatic stress disorder is characterized by an overactive noradrenergic system conferring core posttraumatic stress disorder symptoms such as hyperarousal and reexperiencing. Monoamine oxidase A is one of the key enzymes mediating the turnover of noradrenaline. Here, DNA methylation of the monoamine oxidase A gene exonI/intronI region was investigated for the first time regarding its role in posttraumatic stress disorder risk and severity.Methods: Monoamine oxidase A methylation was analyzed via direct sequencing of sodium bisulfite-treated DNA extracted from blood cells in a total sample of N = 652 ( 441 male) patients with current posttraumatic stress disorder, patients with remitted posttraumatic stress disorder, and healthy probands (comparison group) recruited at 5 centers in Bosnia-Herzegovina, Croatia, and the Republic of Kosovo. Posttraumatic stress disorder severity was measured by means of the Clinician-Administered Posttraumatic Stress Disorder Scale and its respective subscores representing distinct symptom clusters.Results: In the male, but not the female sample, patients with current posttraumatic stress disorder displayed hypermethylation of 3 CpGs (CpG3 = 43 656 362; CpG12 = 43 656 514; CpG13 = 43 656 553, GRCh38.p2 Assembly) as compared with remitted Posttraumatic Stress Disorder patients and healthy probands. Symptom severity (Clinician-Administered Posttraumatic Stress Disorder Scale scores) in male patients with current posttraumatic stress disorder significantly correlated with monoamine oxidase A methylation. This applied particularly to symptom clusters related to reexperiencing of trauma (cluster B) and hyperarousal (cluster D).Conclusions: The present findings suggest monoamine oxidase A gene hypermethylation, potentially resulting in enhanced noradrenergic signalling, as a disease status and severity marker of current posttraumatic stress disorder in males. If replicated, monoamine oxidase A hypermethylation might serve as a surrogate marker of a hyperadrenergic subtype of posttraumatic stress disorder guiding personalized treatment decisions on the use of antiadrenergic agents |
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| spelling | Ziegler, Christiane 1989- VerfasserIn (DE-588)1134988311 (DE-627)889919089 (DE-576)489613543 aut, Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder first evidence from the South Eastern Europe (SEE)-PTSD study Christiane Ziegler, Miriam A. Schiele, Katharina Domschke, Cambridge Univ. Press 2017, Freiburg Albert-Ludwigs-Universität Freiburg 2021, 1 Online-Ressource (10 Seiten) Diagramme, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Abstract: Background: Posttraumatic stress disorder is characterized by an overactive noradrenergic system conferring core posttraumatic stress disorder symptoms such as hyperarousal and reexperiencing. Monoamine oxidase A is one of the key enzymes mediating the turnover of noradrenaline. Here, DNA methylation of the monoamine oxidase A gene exonI/intronI region was investigated for the first time regarding its role in posttraumatic stress disorder risk and severity.Methods: Monoamine oxidase A methylation was analyzed via direct sequencing of sodium bisulfite-treated DNA extracted from blood cells in a total sample of N = 652 ( 441 male) patients with current posttraumatic stress disorder, patients with remitted posttraumatic stress disorder, and healthy probands (comparison group) recruited at 5 centers in Bosnia-Herzegovina, Croatia, and the Republic of Kosovo. Posttraumatic stress disorder severity was measured by means of the Clinician-Administered Posttraumatic Stress Disorder Scale and its respective subscores representing distinct symptom clusters.Results: In the male, but not the female sample, patients with current posttraumatic stress disorder displayed hypermethylation of 3 CpGs (CpG3 = 43 656 362; CpG12 = 43 656 514; CpG13 = 43 656 553, GRCh38.p2 Assembly) as compared with remitted Posttraumatic Stress Disorder patients and healthy probands. Symptom severity (Clinician-Administered Posttraumatic Stress Disorder Scale scores) in male patients with current posttraumatic stress disorder significantly correlated with monoamine oxidase A methylation. This applied particularly to symptom clusters related to reexperiencing of trauma (cluster B) and hyperarousal (cluster D).Conclusions: The present findings suggest monoamine oxidase A gene hypermethylation, potentially resulting in enhanced noradrenergic signalling, as a disease status and severity marker of current posttraumatic stress disorder in males. If replicated, monoamine oxidase A hypermethylation might serve as a surrogate marker of a hyperadrenergic subtype of posttraumatic stress disorder guiding personalized treatment decisions on the use of antiadrenergic agents, Schiele, Miriam A. 1986- VerfasserIn (DE-588)1181272432 (DE-627)1662663358 aut, Domschke, Katharina 1978- VerfasserIn (DE-588)129665525 (DE-627)477109616 (DE-576)297775065 aut, Sonderdruck aus The international journal of neuropsychopharmacology 21, 5 (2018), 423–432 1469-5111, https://nbn-resolving.de/urn:nbn:de:bsz:25-freidok-1751060 application/pdf Resolving-System kostenfrei, https://doi.org/10.1093/ijnp/pyx111 2022-02-07 Resolving-System kostenfrei, https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-1751060 2022-02-07 Resolving-System, https://d-nb.info/1224808738/34 2022-02-07 Langzeitarchivierung Nationalbibliothek, https://freidok.uni-freiburg.de/data/175106 application/pdf 2022-02-07 Verlag kostenfrei, https://doi.org/10.1093/ijnp/pyx111 LFER, https://nbn-resolving.de/urn:nbn:de:bsz:25-freidok-1751060 LFER, LFER 2021-05-04T11:29:42Z |
| spellingShingle | Ziegler, Christiane, Schiele, Miriam A., Domschke, Katharina, Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder: first evidence from the South Eastern Europe (SEE)-PTSD study, Abstract: Background: Posttraumatic stress disorder is characterized by an overactive noradrenergic system conferring core posttraumatic stress disorder symptoms such as hyperarousal and reexperiencing. Monoamine oxidase A is one of the key enzymes mediating the turnover of noradrenaline. Here, DNA methylation of the monoamine oxidase A gene exonI/intronI region was investigated for the first time regarding its role in posttraumatic stress disorder risk and severity.Methods: Monoamine oxidase A methylation was analyzed via direct sequencing of sodium bisulfite-treated DNA extracted from blood cells in a total sample of N = 652 ( 441 male) patients with current posttraumatic stress disorder, patients with remitted posttraumatic stress disorder, and healthy probands (comparison group) recruited at 5 centers in Bosnia-Herzegovina, Croatia, and the Republic of Kosovo. Posttraumatic stress disorder severity was measured by means of the Clinician-Administered Posttraumatic Stress Disorder Scale and its respective subscores representing distinct symptom clusters.Results: In the male, but not the female sample, patients with current posttraumatic stress disorder displayed hypermethylation of 3 CpGs (CpG3 = 43 656 362; CpG12 = 43 656 514; CpG13 = 43 656 553, GRCh38.p2 Assembly) as compared with remitted Posttraumatic Stress Disorder patients and healthy probands. Symptom severity (Clinician-Administered Posttraumatic Stress Disorder Scale scores) in male patients with current posttraumatic stress disorder significantly correlated with monoamine oxidase A methylation. This applied particularly to symptom clusters related to reexperiencing of trauma (cluster B) and hyperarousal (cluster D).Conclusions: The present findings suggest monoamine oxidase A gene hypermethylation, potentially resulting in enhanced noradrenergic signalling, as a disease status and severity marker of current posttraumatic stress disorder in males. If replicated, monoamine oxidase A hypermethylation might serve as a surrogate marker of a hyperadrenergic subtype of posttraumatic stress disorder guiding personalized treatment decisions on the use of antiadrenergic agents |
| title | Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder: first evidence from the South Eastern Europe (SEE)-PTSD study |
| title_auth | Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder first evidence from the South Eastern Europe (SEE)-PTSD study |
| title_full | Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder first evidence from the South Eastern Europe (SEE)-PTSD study Christiane Ziegler, Miriam A. Schiele, Katharina Domschke |
| title_fullStr | Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder first evidence from the South Eastern Europe (SEE)-PTSD study Christiane Ziegler, Miriam A. Schiele, Katharina Domschke |
| title_full_unstemmed | Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder first evidence from the South Eastern Europe (SEE)-PTSD study Christiane Ziegler, Miriam A. Schiele, Katharina Domschke |
| title_in_hierarchy | |
| title_short | Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder |
| title_sort | monoamine oxidase a gene methylation and its role in posttraumatic stress disorder first evidence from the south eastern europe see ptsd study |
| title_sub | first evidence from the South Eastern Europe (SEE)-PTSD study |
| url | https://nbn-resolving.de/urn:nbn:de:bsz:25-freidok-1751060, https://doi.org/10.1093/ijnp/pyx111, https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-1751060, https://d-nb.info/1224808738/34, https://freidok.uni-freiburg.de/data/175106 |
| urn | urn:nbn:de:bsz:25-freidok-1751060 |