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Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder: first evidence from the South Eastern Europe (SEE)-PTSD study
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| Veröffentlicht in: | The international journal of neuropsychopharmacology 21, 5 (2018), 423–432 |
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| Personen und Körperschaften: | , , |
| Titel: | Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder: first evidence from the South Eastern Europe (SEE)-PTSD study/ Christiane Ziegler, Miriam A. Schiele, Katharina Domschke |
| Format: | E-Book Sonderdruck |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge
Univ. Press
2017
Freiburg Albert-Ludwigs-Universität Freiburg 2021 |
| Gesamtaufnahme: |
Monoamine oxidase a gene methylation and its role in posttraumatic stress disorder; 21, 5 (2018), 423–432
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| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| Zusammenfassung: | Abstract: Background: Posttraumatic stress disorder is characterized by an overactive noradrenergic system conferring core posttraumatic stress disorder symptoms such as hyperarousal and reexperiencing. Monoamine oxidase A is one of the key enzymes mediating the turnover of noradrenaline. Here, DNA methylation of the monoamine oxidase A gene exonI/intronI region was investigated for the first time regarding its role in posttraumatic stress disorder risk and severity.Methods: Monoamine oxidase A methylation was analyzed via direct sequencing of sodium bisulfite-treated DNA extracted from blood cells in a total sample of N = 652 ( 441 male) patients with current posttraumatic stress disorder, patients with remitted posttraumatic stress disorder, and healthy probands (comparison group) recruited at 5 centers in Bosnia-Herzegovina, Croatia, and the Republic of Kosovo. Posttraumatic stress disorder severity was measured by means of the Clinician-Administered Posttraumatic Stress Disorder Scale and its respective subscores representing distinct symptom clusters.Results: In the male, but not the female sample, patients with current posttraumatic stress disorder displayed hypermethylation of 3 CpGs (CpG3 = 43 656 362; CpG12 = 43 656 514; CpG13 = 43 656 553, GRCh38.p2 Assembly) as compared with remitted Posttraumatic Stress Disorder patients and healthy probands. Symptom severity (Clinician-Administered Posttraumatic Stress Disorder Scale scores) in male patients with current posttraumatic stress disorder significantly correlated with monoamine oxidase A methylation. This applied particularly to symptom clusters related to reexperiencing of trauma (cluster B) and hyperarousal (cluster D).Conclusions: The present findings suggest monoamine oxidase A gene hypermethylation, potentially resulting in enhanced noradrenergic signalling, as a disease status and severity marker of current posttraumatic stress disorder in males. If replicated, monoamine oxidase A hypermethylation might serve as a surrogate marker of a hyperadrenergic subtype of posttraumatic stress disorder guiding personalized treatment decisions on the use of antiadrenergic agents |
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| Umfang: | 1 Online-Ressource (10 Seiten); Diagramme |
| ISSN: |
1469-5111
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| DOI: | 10.1093/ijnp/pyx111 |