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MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B
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| Veröffentlicht in: | BMC cancer 18(2018) Artikel-Nummer 663, 12 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| Titel: | MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B/ David M. Cordas dos Santos, Juliane Eilers, Alfonso Sosa Vizcaino, Elena Orlova, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Kathleen Börner, Dirk Grimm, Martina U. Muckenthaler, Andreas E. Kulozik and Joachim B. Kunz |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
18 June 2018
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| Gesamtaufnahme: |
: BMC cancer, 18(2018) Artikel-Nummer 663, 12 Seiten
, volume:18 |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B |c David M. Cordas dos Santos, Juliane Eilers, Alfonso Sosa Vizcaino, Elena Orlova, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Kathleen Börner, Dirk Grimm, Martina U. Muckenthaler, Andreas E. Kulozik and Joachim B. Kunz |
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| 520 | |a Deletions of 6q15-16.1 are recurrently found in pediatric T-cell acute lymphoblastic leukemia (T-ALL). This chromosomal region includes the mitogen-activated protein kinase kinase kinase 7 (MAP3K7) gene which has a crucial role in innate immune signaling and was observed to be functionally and prognostically relevant in different cancer entities. Therefore, we correlated the presence of MAP3K7 deletions with clinical parameters in a cohort of 327 pediatric T-ALL patients and investigated the function of MAP3K7 in the T-ALL cell lines CCRF-CEM, Jurkat and MOLT-4. | ||
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| author | Santos, David M. Cordas dos, Eilers, Juliane, Orlova, Elena, Börner, Kathleen, Grimm, Dirk, Muckenthaler, Martina, Kulozik, Andreas, Kunz, Joachim |
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| contents | Deletions of 6q15-16.1 are recurrently found in pediatric T-cell acute lymphoblastic leukemia (T-ALL). This chromosomal region includes the mitogen-activated protein kinase kinase kinase 7 (MAP3K7) gene which has a crucial role in innate immune signaling and was observed to be functionally and prognostically relevant in different cancer entities. Therefore, we correlated the presence of MAP3K7 deletions with clinical parameters in a cohort of 327 pediatric T-ALL patients and investigated the function of MAP3K7 in the T-ALL cell lines CCRF-CEM, Jurkat and MOLT-4. |
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| spelling | Santos, David M. Cordas dos VerfasserIn (DE-588)1162512563 (DE-627)1026614457 (DE-576)507448464 aut, MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B David M. Cordas dos Santos, Juliane Eilers, Alfonso Sosa Vizcaino, Elena Orlova, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Kathleen Börner, Dirk Grimm, Martina U. Muckenthaler, Andreas E. Kulozik and Joachim B. Kunz, κ kappa, 18 June 2018, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 10.07.2018, Deletions of 6q15-16.1 are recurrently found in pediatric T-cell acute lymphoblastic leukemia (T-ALL). This chromosomal region includes the mitogen-activated protein kinase kinase kinase 7 (MAP3K7) gene which has a crucial role in innate immune signaling and was observed to be functionally and prognostically relevant in different cancer entities. Therefore, we correlated the presence of MAP3K7 deletions with clinical parameters in a cohort of 327 pediatric T-ALL patients and investigated the function of MAP3K7 in the T-ALL cell lines CCRF-CEM, Jurkat and MOLT-4., chr6q15 deletion, MAP3K7, T-ALL, T-cell acute lymphoblastic leukemia, TGF-beta activated kinase 1, Eilers, Juliane 1987- VerfasserIn (DE-588)1162512830 (DE-627)1026615674 (DE-576)507448936 aut, Orlova, Elena VerfasserIn (DE-588)1160458731 (DE-627)1023638908 (DE-576)505907070 aut, Börner, Kathleen VerfasserIn (DE-588)1030276382 (DE-627)734977727 (DE-576)378068806 aut, Grimm, Dirk VerfasserIn (DE-588)1016476671 (DE-627)70553376X (DE-576)352260645 aut, Muckenthaler, Martina VerfasserIn (DE-588)1046124595 (DE-627)775766496 (DE-576)173146813 aut, Kulozik, Andreas 1959- VerfasserIn (DE-588)1025736567 (DE-627)723892032 (DE-576)167091638 aut, Kunz, Joachim 1974- VerfasserIn (DE-588)124297730 (DE-627)085769029 (DE-576)294107703 aut, Enthalten in BMC cancer London : BioMed Central, 2001 18(2018) Artikel-Nummer 663, 12 Seiten Online-Ressource (DE-627)326643710 (DE-600)2041352-X (DE-576)107014645 1471-2407 nnns, volume:18 year:2018, http://dx.doi.org/10.1186/s12885-018-4525-0 Verlag Resolving-System kostenfrei Volltext, https://doi.org/10.1186/s12885-018-4525-0 Verlag kostenfrei Volltext, http://dx.doi.org/10.1186/s12885-018-4525-0 LFER, LFER 2018-08-13T00:00:00Z |
| spellingShingle | Santos, David M. Cordas dos, Eilers, Juliane, Orlova, Elena, Börner, Kathleen, Grimm, Dirk, Muckenthaler, Martina, Kulozik, Andreas, Kunz, Joachim, MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B, Deletions of 6q15-16.1 are recurrently found in pediatric T-cell acute lymphoblastic leukemia (T-ALL). This chromosomal region includes the mitogen-activated protein kinase kinase kinase 7 (MAP3K7) gene which has a crucial role in innate immune signaling and was observed to be functionally and prognostically relevant in different cancer entities. Therefore, we correlated the presence of MAP3K7 deletions with clinical parameters in a cohort of 327 pediatric T-ALL patients and investigated the function of MAP3K7 in the T-ALL cell lines CCRF-CEM, Jurkat and MOLT-4., chr6q15 deletion, MAP3K7, T-ALL, T-cell acute lymphoblastic leukemia, TGF-beta activated kinase 1 |
| swb_id_str | 507451821 |
| title | MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B |
| title_alt | κ kappa |
| title_auth | MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B |
| title_full | MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B David M. Cordas dos Santos, Juliane Eilers, Alfonso Sosa Vizcaino, Elena Orlova, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Kathleen Börner, Dirk Grimm, Martina U. Muckenthaler, Andreas E. Kulozik and Joachim B. Kunz |
| title_fullStr | MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B David M. Cordas dos Santos, Juliane Eilers, Alfonso Sosa Vizcaino, Elena Orlova, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Kathleen Börner, Dirk Grimm, Martina U. Muckenthaler, Andreas E. Kulozik and Joachim B. Kunz |
| title_full_unstemmed | MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B David M. Cordas dos Santos, Juliane Eilers, Alfonso Sosa Vizcaino, Elena Orlova, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Kathleen Börner, Dirk Grimm, Martina U. Muckenthaler, Andreas E. Kulozik and Joachim B. Kunz |
| title_in_hierarchy | MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B / David M. Cordas dos Santos, Juliane Eilers, Alfonso Sosa Vizcaino, Elena Orlova, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Kathleen Börner, Dirk Grimm, Martina U. Muckenthaler, Andreas E. Kulozik and Joachim B. Kunz, |
| title_short | MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-[kappa]B |
| title_sort | map3k7 is recurrently deleted in pediatric t lymphoblastic leukemia and affects cell proliferation independently of nf kappa b |
| topic | chr6q15 deletion, MAP3K7, T-ALL, T-cell acute lymphoblastic leukemia, TGF-beta activated kinase 1 |
| topic_facet | chr6q15 deletion, MAP3K7, T-ALL, T-cell acute lymphoblastic leukemia, TGF-beta activated kinase 1 |
| url | http://dx.doi.org/10.1186/s12885-018-4525-0, https://doi.org/10.1186/s12885-018-4525-0 |