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Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment
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| Veröffentlicht in: | Biophysical journal 102(2012), 5, Seite 1032-1038 |
|---|---|
| Personen und Körperschaften: | , , |
| Titel: | Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment/ C. Westerhausen, F.G. Strobl, R. Herrmann, A.T. Bauer, S.W. Schneider, A. Reller, A. Wixforth, M.F. Schneider |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
7 March 2012
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| Gesamtaufnahme: |
: Biophysical journal, 102(2012), 5, Seite 1032-1038
, volume:102 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment |c C. Westerhausen, F.G. Strobl, R. Herrmann, A.T. Bauer, S.W. Schneider, A. Reller, A. Wixforth, M.F. Schneider |
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| 520 | |a The interaction of nanoparticles (NPs) with lipid membranes is an integral step in the interaction of NPs and living cells. During particle uptake, the membrane has to bend. Due to the nature of their phase diagram, the modulus of compression of these membranes can vary by more than one order of magnitude, and thus both the thermodynamic and mechanical aspects of the membrane have to be considered simultaneously. We demonstrate that silica NPs have at least two independent effects on the phase transition of phospholipid membranes: 1), a chemical effect resulting from the finite instability of the NPs in water; and 2), a mechanical effect that originates from a bending of the lipid membrane around the NPs. Here, we report on recent experiments that allowed us to clearly distinguish both effects, and present a thermodynamic model that includes the elastic energy of the membranes and correctly predicts our findings both quantitatively and qualitatively. | ||
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| contents | The interaction of nanoparticles (NPs) with lipid membranes is an integral step in the interaction of NPs and living cells. During particle uptake, the membrane has to bend. Due to the nature of their phase diagram, the modulus of compression of these membranes can vary by more than one order of magnitude, and thus both the thermodynamic and mechanical aspects of the membrane have to be considered simultaneously. We demonstrate that silica NPs have at least two independent effects on the phase transition of phospholipid membranes: 1), a chemical effect resulting from the finite instability of the NPs in water; and 2), a mechanical effect that originates from a bending of the lipid membrane around the NPs. Here, we report on recent experiments that allowed us to clearly distinguish both effects, and present a thermodynamic model that includes the elastic energy of the membranes and correctly predicts our findings both quantitatively and qualitatively. |
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| spelling | Westerhausen, Christoph 1984- VerfasserIn (DE-588)1030241376 (DE-627)734959818 (DE-576)378049410 aut, Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment C. Westerhausen, F.G. Strobl, R. Herrmann, A.T. Bauer, S.W. Schneider, A. Reller, A. Wixforth, M.F. Schneider, 7 March 2012, 7, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 16.04.2018, The interaction of nanoparticles (NPs) with lipid membranes is an integral step in the interaction of NPs and living cells. During particle uptake, the membrane has to bend. Due to the nature of their phase diagram, the modulus of compression of these membranes can vary by more than one order of magnitude, and thus both the thermodynamic and mechanical aspects of the membrane have to be considered simultaneously. We demonstrate that silica NPs have at least two independent effects on the phase transition of phospholipid membranes: 1), a chemical effect resulting from the finite instability of the NPs in water; and 2), a mechanical effect that originates from a bending of the lipid membrane around the NPs. Here, we report on recent experiments that allowed us to clearly distinguish both effects, and present a thermodynamic model that includes the elastic energy of the membranes and correctly predicts our findings both quantitatively and qualitatively., Bauer, Alexander 1978- VerfasserIn (DE-588)143496425 (DE-627)646577778 (DE-576)337385572 aut, Schneider, Stefan W. 1966- VerfasserIn (DE-588)137570546 (DE-627)593664868 (DE-576)304124702 aut, Enthalten in Biophysical journal Cambridge, Mass. : Cell Press, 1960 102(2012), 5, Seite 1032-1038 Online-Ressource (DE-627)270425357 (DE-600)1477214-0 (DE-576)091017602 1542-0086 nnns, volume:102 year:2012 number:5 pages:1032-1038 extent:7, http://dx.doi.org/10.1016/j.bpj.2011.12.004 Verlag Resolving-System kostenfrei Volltext, http://www.sciencedirect.com/science/article/pii/S0006349511053707 Verlag kostenfrei Volltext, http://dx.doi.org/10.1016/j.bpj.2011.12.004 LFER, LFER 2018-05-17T00:00:00Z |
| spellingShingle | Westerhausen, Christoph, Bauer, Alexander, Schneider, Stefan W., Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment, The interaction of nanoparticles (NPs) with lipid membranes is an integral step in the interaction of NPs and living cells. During particle uptake, the membrane has to bend. Due to the nature of their phase diagram, the modulus of compression of these membranes can vary by more than one order of magnitude, and thus both the thermodynamic and mechanical aspects of the membrane have to be considered simultaneously. We demonstrate that silica NPs have at least two independent effects on the phase transition of phospholipid membranes: 1), a chemical effect resulting from the finite instability of the NPs in water; and 2), a mechanical effect that originates from a bending of the lipid membrane around the NPs. Here, we report on recent experiments that allowed us to clearly distinguish both effects, and present a thermodynamic model that includes the elastic energy of the membranes and correctly predicts our findings both quantitatively and qualitatively. |
| swb_id_str | 502036001 |
| title | Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment |
| title_auth | Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment |
| title_full | Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment C. Westerhausen, F.G. Strobl, R. Herrmann, A.T. Bauer, S.W. Schneider, A. Reller, A. Wixforth, M.F. Schneider |
| title_fullStr | Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment C. Westerhausen, F.G. Strobl, R. Herrmann, A.T. Bauer, S.W. Schneider, A. Reller, A. Wixforth, M.F. Schneider |
| title_full_unstemmed | Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment C. Westerhausen, F.G. Strobl, R. Herrmann, A.T. Bauer, S.W. Schneider, A. Reller, A. Wixforth, M.F. Schneider |
| title_in_hierarchy | Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment / C. Westerhausen, F.G. Strobl, R. Herrmann, A.T. Bauer, S.W. Schneider, A. Reller, A. Wixforth, M.F. Schneider, |
| title_short | Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment |
| title_sort | chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment |
| url | http://dx.doi.org/10.1016/j.bpj.2011.12.004, http://www.sciencedirect.com/science/article/pii/S0006349511053707 |