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Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment
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| Veröffentlicht in: | Biophysical journal 102(2012), 5, Seite 1032-1038 |
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| Personen und Körperschaften: | , , |
| Titel: | Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment/ C. Westerhausen, F.G. Strobl, R. Herrmann, A.T. Bauer, S.W. Schneider, A. Reller, A. Wixforth, M.F. Schneider |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
7 March 2012
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| Gesamtaufnahme: |
: Biophysical journal, 102(2012), 5, Seite 1032-1038
, volume:102 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| Zusammenfassung: | The interaction of nanoparticles (NPs) with lipid membranes is an integral step in the interaction of NPs and living cells. During particle uptake, the membrane has to bend. Due to the nature of their phase diagram, the modulus of compression of these membranes can vary by more than one order of magnitude, and thus both the thermodynamic and mechanical aspects of the membrane have to be considered simultaneously. We demonstrate that silica NPs have at least two independent effects on the phase transition of phospholipid membranes: 1), a chemical effect resulting from the finite instability of the NPs in water; and 2), a mechanical effect that originates from a bending of the lipid membrane around the NPs. Here, we report on recent experiments that allowed us to clearly distinguish both effects, and present a thermodynamic model that includes the elastic energy of the membranes and correctly predicts our findings both quantitatively and qualitatively. |
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| Beschreibung: | Gesehen am 16.04.2018 |
| Umfang: | 7 |
| ISSN: |
1542-0086
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| DOI: | 10.1016/j.bpj.2011.12.004 |