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The cis‐regulatory code of Hox function in Drosophila
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| Veröffentlicht in: | The EMBO journal 31(2012), 15, Seite 3323-3333 |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| Titel: | The cis‐regulatory code of Hox function in Drosophila/ Sebastian Sorge, Nati Ha, Maria Polychronidou, Jana Friedrich, Daniela Bezdan, Petra Kaspar, Martin H. Schaefer, Stephan Ossowski, Stefan R. Henz, Juliane Mundorf, Jenny Rätzer, Fani Papagiannouli and Ingrid Lohmann |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
10 July 2012
|
| Gesamtaufnahme: |
European Molecular Biology Organization: The EMBO journal, 31(2012), 15, Seite 3323-3333
, volume:31 |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| Errata: |
Sorge, Sebastian: Corrigendum |
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| 520 | |a Precise gene expression is a fundamental aspect of organismal function and depends on the combinatorial interplay of transcription factors (TFs) with cis‐regulatory DNA elements. While much is known about TF function in general, our understanding of their cell type‐specific activities is still poor. To address how widely expressed transcriptional regulators modulate downstream gene activity with high cellular specificity, we have identified binding regions for the Hox TF Deformed (Dfd) in the Drosophila genome. Our analysis of architectural features within Hox cis‐regulatory response elements (HREs) shows that HRE structure is essential for cell type‐specific gene expression. We also find that Dfd and Ultrabithorax (Ubx), another Hox TF specifying different morphological traits, interact with non‐overlapping regions in vivo, despite their similar DNA binding preferences. While Dfd and Ubx HREs exhibit comparable design principles, their motif compositions and motif‐pair associations are distinct, explaining the highly selective interaction of these Hox proteins with the regulatory environment. Thus, our results uncover the regulatory code imprinted in Hox enhancers and elucidate the mechanisms underlying functional specificity of TFs in vivo. | ||
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| author | Sorge, Sebastian, Ha, Nati, Polychronidou, Maria, Friedrich, Jana, Kaspar, Petra, Mundorf, Juliane, Rätzer, Jenny, Papagiannouli, Fani, Lohmann, Ingrid |
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| contents | Precise gene expression is a fundamental aspect of organismal function and depends on the combinatorial interplay of transcription factors (TFs) with cis‐regulatory DNA elements. While much is known about TF function in general, our understanding of their cell type‐specific activities is still poor. To address how widely expressed transcriptional regulators modulate downstream gene activity with high cellular specificity, we have identified binding regions for the Hox TF Deformed (Dfd) in the Drosophila genome. Our analysis of architectural features within Hox cis‐regulatory response elements (HREs) shows that HRE structure is essential for cell type‐specific gene expression. We also find that Dfd and Ultrabithorax (Ubx), another Hox TF specifying different morphological traits, interact with non‐overlapping regions in vivo, despite their similar DNA binding preferences. While Dfd and Ubx HREs exhibit comparable design principles, their motif compositions and motif‐pair associations are distinct, explaining the highly selective interaction of these Hox proteins with the regulatory environment. Thus, our results uncover the regulatory code imprinted in Hox enhancers and elucidate the mechanisms underlying functional specificity of TFs in vivo. |
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| spelling | Sorge, Sebastian VerfasserIn (DE-588)1081403624 (DE-627)846068877 (DE-576)454389558 aut, The cis‐regulatory code of Hox function in Drosophila Sebastian Sorge, Nati Ha, Maria Polychronidou, Jana Friedrich, Daniela Bezdan, Petra Kaspar, Martin H. Schaefer, Stephan Ossowski, Stefan R. Henz, Juliane Mundorf, Jenny Rätzer, Fani Papagiannouli and Ingrid Lohmann, 10 July 2012, 11, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 24.08.2017, Precise gene expression is a fundamental aspect of organismal function and depends on the combinatorial interplay of transcription factors (TFs) with cis‐regulatory DNA elements. While much is known about TF function in general, our understanding of their cell type‐specific activities is still poor. To address how widely expressed transcriptional regulators modulate downstream gene activity with high cellular specificity, we have identified binding regions for the Hox TF Deformed (Dfd) in the Drosophila genome. Our analysis of architectural features within Hox cis‐regulatory response elements (HREs) shows that HRE structure is essential for cell type‐specific gene expression. We also find that Dfd and Ultrabithorax (Ubx), another Hox TF specifying different morphological traits, interact with non‐overlapping regions in vivo, despite their similar DNA binding preferences. While Dfd and Ubx HREs exhibit comparable design principles, their motif compositions and motif‐pair associations are distinct, explaining the highly selective interaction of these Hox proteins with the regulatory environment. Thus, our results uncover the regulatory code imprinted in Hox enhancers and elucidate the mechanisms underlying functional specificity of TFs in vivo., ChIP‐seq, Deformed, Drosophila, Hox, transcriptional gene regulation, Ha, Nati VerfasserIn (DE-588)1035472090 (DE-627)749337613 (DE-576)383063256 aut, Polychronidou, Maria VerfasserIn (DE-588)1132146267 (DE-627)887440738 (DE-576)357857607 aut, Friedrich, Jana VerfasserIn (DE-588)1081403594 (DE-627)846060418 (DE-576)454389434 aut, Kaspar, Petra 1979- VerfasserIn (DE-588)139007040 (DE-627)607763752 (DE-576)28831963X aut, Mundorf, Juliane VerfasserIn (DE-588)1138800600 (DE-627)896385027 (DE-576)492701741 aut, Rätzer, Jenny 1987- VerfasserIn (DE-588)1138800961 (DE-627)89638568X (DE-576)492702144 aut, Papagiannouli, Fani 1975- VerfasserIn (DE-588)128951923 (DE-627)386139385 (DE-576)187785260 aut, Lohmann, Ingrid VerfasserIn (DE-588)1047761831 (DE-627)779177215 (DE-576)401571688 aut, Enthalten in European Molecular Biology Organization The EMBO journal Heidelberg : EMBO Press, 1982 31(2012), 15, Seite 3323-3333 (DE-627)266022529 (DE-600)1467419-1 (DE-576)075961377 1460-2075 nnns, volume:31 year:2012 number:15 pages:3323-3333 extent:11, Errata Sorge, Sebastian Corrigendum 2015 (DE-627)170113313X, http://dx.doi.org/10.1038/emboj.2012.179 Verlag Resolving-System kostenfrei Volltext, http://embojnl.embopress.org/content/31/15/3323 Verlag kostenfrei Volltext, http://dx.doi.org/10.1038/emboj.2012.179 LFER, LFER 2017-09-14T00:00:00Z |
| spellingShingle | Sorge, Sebastian, Ha, Nati, Polychronidou, Maria, Friedrich, Jana, Kaspar, Petra, Mundorf, Juliane, Rätzer, Jenny, Papagiannouli, Fani, Lohmann, Ingrid, The cis‐regulatory code of Hox function in Drosophila, Precise gene expression is a fundamental aspect of organismal function and depends on the combinatorial interplay of transcription factors (TFs) with cis‐regulatory DNA elements. While much is known about TF function in general, our understanding of their cell type‐specific activities is still poor. To address how widely expressed transcriptional regulators modulate downstream gene activity with high cellular specificity, we have identified binding regions for the Hox TF Deformed (Dfd) in the Drosophila genome. Our analysis of architectural features within Hox cis‐regulatory response elements (HREs) shows that HRE structure is essential for cell type‐specific gene expression. We also find that Dfd and Ultrabithorax (Ubx), another Hox TF specifying different morphological traits, interact with non‐overlapping regions in vivo, despite their similar DNA binding preferences. While Dfd and Ubx HREs exhibit comparable design principles, their motif compositions and motif‐pair associations are distinct, explaining the highly selective interaction of these Hox proteins with the regulatory environment. Thus, our results uncover the regulatory code imprinted in Hox enhancers and elucidate the mechanisms underlying functional specificity of TFs in vivo., ChIP‐seq, Deformed, Drosophila, Hox, transcriptional gene regulation |
| swb_id_str | 492702454 |
| title | The cis‐regulatory code of Hox function in Drosophila |
| title_auth | The cis‐regulatory code of Hox function in Drosophila |
| title_full | The cis‐regulatory code of Hox function in Drosophila Sebastian Sorge, Nati Ha, Maria Polychronidou, Jana Friedrich, Daniela Bezdan, Petra Kaspar, Martin H. Schaefer, Stephan Ossowski, Stefan R. Henz, Juliane Mundorf, Jenny Rätzer, Fani Papagiannouli and Ingrid Lohmann |
| title_fullStr | The cis‐regulatory code of Hox function in Drosophila Sebastian Sorge, Nati Ha, Maria Polychronidou, Jana Friedrich, Daniela Bezdan, Petra Kaspar, Martin H. Schaefer, Stephan Ossowski, Stefan R. Henz, Juliane Mundorf, Jenny Rätzer, Fani Papagiannouli and Ingrid Lohmann |
| title_full_unstemmed | The cis‐regulatory code of Hox function in Drosophila Sebastian Sorge, Nati Ha, Maria Polychronidou, Jana Friedrich, Daniela Bezdan, Petra Kaspar, Martin H. Schaefer, Stephan Ossowski, Stefan R. Henz, Juliane Mundorf, Jenny Rätzer, Fani Papagiannouli and Ingrid Lohmann |
| title_in_hierarchy | The cis‐regulatory code of Hox function in Drosophila / Sebastian Sorge, Nati Ha, Maria Polychronidou, Jana Friedrich, Daniela Bezdan, Petra Kaspar, Martin H. Schaefer, Stephan Ossowski, Stefan R. Henz, Juliane Mundorf, Jenny Rätzer, Fani Papagiannouli and Ingrid Lohmann, |
| title_short | The cis‐regulatory code of Hox function in Drosophila |
| title_sort | cis regulatory code of hox function in drosophila |
| topic | ChIP‐seq, Deformed, Drosophila, Hox, transcriptional gene regulation |
| topic_facet | ChIP‐seq, Deformed, Drosophila, Hox, transcriptional gene regulation |
| url | http://dx.doi.org/10.1038/emboj.2012.179, http://embojnl.embopress.org/content/31/15/3323 |