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Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation
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| Veröffentlicht in: | The journal of cell biology 183(2008), 5, Seite 805-818 |
|---|---|
| Personen und Körperschaften: | |
| Titel: | Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation/ Sylvia Erhardt, Barbara G. Mellone, Craig M. Betts, Weiguo Zhang, Gary H. Karpen, and Aaron F. Straight |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
December 1, 2008
|
| Gesamtaufnahme: |
: The journal of cell biology, 183(2008), 5, Seite 805-818
, volume:183 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation |c Sylvia Erhardt, Barbara G. Mellone, Craig M. Betts, Weiguo Zhang, Gary H. Karpen, and Aaron F. Straight |
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| 520 | |a Centromeres are the structural and functional foundation for kinetochore formation, spindle attachment, and chromosome segregation. In this study, we isolated factors required for centromere propagation using genome-wide RNA interference screening for defects in centromere protein A (CENP-A; centromere identifier [CID]) localization in Drosophila melanogaster. We identified the proteins CAL1 and CENP-C as essential factors for CID assembly at the centromere. CID, CAL1, and CENP-C coimmunoprecipitate and are mutually dependent for centromere localization and function. We also identified the mitotic cyclin A (CYCA) and the anaphase-promoting complex (APC) inhibitor RCA1/Emi1 as regulators of centromere propagation. We show that CYCA is centromere localized and that CYCA and RCA1/Emi1 couple centromere assembly to the cell cycle through regulation of the fizzy-related/CDH1 subunit of the APC. Our findings identify essential components of the epigenetic machinery that ensures proper specification and propagation of the centromere and suggest a mechanism for coordinating centromere inheritance with cell division. | ||
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| contents | Centromeres are the structural and functional foundation for kinetochore formation, spindle attachment, and chromosome segregation. In this study, we isolated factors required for centromere propagation using genome-wide RNA interference screening for defects in centromere protein A (CENP-A; centromere identifier [CID]) localization in Drosophila melanogaster. We identified the proteins CAL1 and CENP-C as essential factors for CID assembly at the centromere. CID, CAL1, and CENP-C coimmunoprecipitate and are mutually dependent for centromere localization and function. We also identified the mitotic cyclin A (CYCA) and the anaphase-promoting complex (APC) inhibitor RCA1/Emi1 as regulators of centromere propagation. We show that CYCA is centromere localized and that CYCA and RCA1/Emi1 couple centromere assembly to the cell cycle through regulation of the fizzy-related/CDH1 subunit of the APC. Our findings identify essential components of the epigenetic machinery that ensures proper specification and propagation of the centromere and suggest a mechanism for coordinating centromere inheritance with cell division. |
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| spelling | Erhardt, Sylvia VerfasserIn (DE-588)1130282899 (DE-627)884610047 (DE-576)486722198 aut, Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation Sylvia Erhardt, Barbara G. Mellone, Craig M. Betts, Weiguo Zhang, Gary H. Karpen, and Aaron F. Straight, December 1, 2008, 14, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 15.08.2017, Centromeres are the structural and functional foundation for kinetochore formation, spindle attachment, and chromosome segregation. In this study, we isolated factors required for centromere propagation using genome-wide RNA interference screening for defects in centromere protein A (CENP-A; centromere identifier [CID]) localization in Drosophila melanogaster. We identified the proteins CAL1 and CENP-C as essential factors for CID assembly at the centromere. CID, CAL1, and CENP-C coimmunoprecipitate and are mutually dependent for centromere localization and function. We also identified the mitotic cyclin A (CYCA) and the anaphase-promoting complex (APC) inhibitor RCA1/Emi1 as regulators of centromere propagation. We show that CYCA is centromere localized and that CYCA and RCA1/Emi1 couple centromere assembly to the cell cycle through regulation of the fizzy-related/CDH1 subunit of the APC. Our findings identify essential components of the epigenetic machinery that ensures proper specification and propagation of the centromere and suggest a mechanism for coordinating centromere inheritance with cell division., Enthalten in The journal of cell biology New York, NY : Rockefeller Univ. Press, 1962 183(2008), 5, Seite 805-818 Online-Ressource (DE-627)242065244 (DE-600)1421310-2 (DE-576)065026527 1540-8140 nnns, volume:183 year:2008 number:5 pages:805-818 extent:14, http://dx.doi.org/10.1083/jcb.200806038 Verlag Resolving-System kostenfrei Volltext, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592830/ Verlag kostenfrei Volltext, http://dx.doi.org/10.1083/jcb.200806038 LFER, LFER 2017-09-14T00:00:00Z |
| spellingShingle | Erhardt, Sylvia, Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation, Centromeres are the structural and functional foundation for kinetochore formation, spindle attachment, and chromosome segregation. In this study, we isolated factors required for centromere propagation using genome-wide RNA interference screening for defects in centromere protein A (CENP-A; centromere identifier [CID]) localization in Drosophila melanogaster. We identified the proteins CAL1 and CENP-C as essential factors for CID assembly at the centromere. CID, CAL1, and CENP-C coimmunoprecipitate and are mutually dependent for centromere localization and function. We also identified the mitotic cyclin A (CYCA) and the anaphase-promoting complex (APC) inhibitor RCA1/Emi1 as regulators of centromere propagation. We show that CYCA is centromere localized and that CYCA and RCA1/Emi1 couple centromere assembly to the cell cycle through regulation of the fizzy-related/CDH1 subunit of the APC. Our findings identify essential components of the epigenetic machinery that ensures proper specification and propagation of the centromere and suggest a mechanism for coordinating centromere inheritance with cell division. |
| swb_id_str | 492451931 |
| title | Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation |
| title_auth | Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation |
| title_full | Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation Sylvia Erhardt, Barbara G. Mellone, Craig M. Betts, Weiguo Zhang, Gary H. Karpen, and Aaron F. Straight |
| title_fullStr | Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation Sylvia Erhardt, Barbara G. Mellone, Craig M. Betts, Weiguo Zhang, Gary H. Karpen, and Aaron F. Straight |
| title_full_unstemmed | Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation Sylvia Erhardt, Barbara G. Mellone, Craig M. Betts, Weiguo Zhang, Gary H. Karpen, and Aaron F. Straight |
| title_in_hierarchy | Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation / Sylvia Erhardt, Barbara G. Mellone, Craig M. Betts, Weiguo Zhang, Gary H. Karpen, and Aaron F. Straight, |
| title_short | Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation |
| title_sort | genome wide analysis reveals a cell cycle dependent mechanism controlling centromere propagation |
| url | http://dx.doi.org/10.1083/jcb.200806038, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592830/ |