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Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro
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| Veröffentlicht in: | Journal of virology 89(2015), 14, Seite 7433-7438 |
|---|---|
| Personen und Körperschaften: | , |
| Titel: | Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro/ Alexander Hoh, Maximilian Heeg, Yi Ni, Anita Schuch, Benedikt Binder, Nadine Hennecke, Hubert E. Blum, Michael Nassal, Ulrike Protzer, Maike Hofmann, Stephan Urban, Robert Thimme |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
15 July 2015
|
| Gesamtaufnahme: |
: Journal of virology, 89(2015), 14, Seite 7433-7438
, volume:89 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 520 | |a CD8+ T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8+ T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2hNTCP cells that endogenously processed viral antigens and presented them to HBV-specific CD8+ T cells. This induced cytolytic and noncytolytic CD8+ T-cell effector functions and reduction of viral loads. | ||
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| contents | CD8+ T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8+ T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2hNTCP cells that endogenously processed viral antigens and presented them to HBV-specific CD8+ T cells. This induced cytolytic and noncytolytic CD8+ T-cell effector functions and reduction of viral loads. |
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| spelling | Hoh, Alexander VerfasserIn (DE-588)1024952711 (DE-627)720811961 (DE-576)369725476 aut, Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro Alexander Hoh, Maximilian Heeg, Yi Ni, Anita Schuch, Benedikt Binder, Nadine Hennecke, Hubert E. Blum, Michael Nassal, Ulrike Protzer, Maike Hofmann, Stephan Urban, Robert Thimme, Hepatitis B virus-infected HepG2 hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8 + T cells in vitro, 15 July 2015, 6, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Im Titel ist „hNTCP“ und "+"hochgestellt, Gesehen am 04.04.2017, CD8+ T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8+ T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2hNTCP cells that endogenously processed viral antigens and presented them to HBV-specific CD8+ T cells. This induced cytolytic and noncytolytic CD8+ T-cell effector functions and reduction of viral loads., Urban, Stephan VerfasserIn (DE-588)1060263599 (DE-627)79935399X (DE-576)174162049 aut, Enthalten in Journal of virology Baltimore, Md. : Soc., 1967 89(2015), 14, Seite 7433-7438 Online-Ressource (DE-627)303614609 (DE-600)1495529-5 (DE-576)08088766X 1098-5514 nnns, volume:89 year:2015 number:14 pages:7433-7438 extent:6, http://dx.doi.org/10.1128/JVI.00605-15 Verlag Resolving-System kostenfrei Volltext, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473563/ Verlag kostenfrei Volltext, http://dx.doi.org/10.1128/JVI.00605-15 LFER, LFER 2017-04-13T00:00:00Z |
| spellingShingle | Hoh, Alexander, Urban, Stephan, Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro, CD8+ T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8+ T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2hNTCP cells that endogenously processed viral antigens and presented them to HBV-specific CD8+ T cells. This induced cytolytic and noncytolytic CD8+ T-cell effector functions and reduction of viral loads. |
| swb_id_str | 486246701 |
| title | Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro |
| title_alt | Hepatitis B virus-infected HepG2 hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8 + T cells in vitro |
| title_auth | Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro |
| title_full | Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro Alexander Hoh, Maximilian Heeg, Yi Ni, Anita Schuch, Benedikt Binder, Nadine Hennecke, Hubert E. Blum, Michael Nassal, Ulrike Protzer, Maike Hofmann, Stephan Urban, Robert Thimme |
| title_fullStr | Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro Alexander Hoh, Maximilian Heeg, Yi Ni, Anita Schuch, Benedikt Binder, Nadine Hennecke, Hubert E. Blum, Michael Nassal, Ulrike Protzer, Maike Hofmann, Stephan Urban, Robert Thimme |
| title_full_unstemmed | Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro Alexander Hoh, Maximilian Heeg, Yi Ni, Anita Schuch, Benedikt Binder, Nadine Hennecke, Hubert E. Blum, Michael Nassal, Ulrike Protzer, Maike Hofmann, Stephan Urban, Robert Thimme |
| title_in_hierarchy | Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro / Alexander Hoh, Maximilian Heeg, Yi Ni, Anita Schuch, Benedikt Binder, Nadine Hennecke, Hubert E. Blum, Michael Nassal, Ulrike Protzer, Maike Hofmann, Stephan Urban, Robert Thimme, |
| title_short | Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro |
| title_sort | hepatitis b virus infected hepg2hntcp cells serve as a novel immunological tool to analyze the antiviral efficacy of cd8 t cells in vitro |
| url | http://dx.doi.org/10.1128/JVI.00605-15, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473563/ |