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Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro
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| Veröffentlicht in: | Journal of virology 89(2015), 14, Seite 7433-7438 |
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| Personen und Körperschaften: | , |
| Titel: | Hepatitis B virus-infected HepG2hNTCP cells serve as a novel immunological tool to analyze the antiviral efficacy of CD8+ T cells in vitro/ Alexander Hoh, Maximilian Heeg, Yi Ni, Anita Schuch, Benedikt Binder, Nadine Hennecke, Hubert E. Blum, Michael Nassal, Ulrike Protzer, Maike Hofmann, Stephan Urban, Robert Thimme |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
15 July 2015
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| Gesamtaufnahme: |
: Journal of virology, 89(2015), 14, Seite 7433-7438
, volume:89 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| Zusammenfassung: | CD8+ T cells are the main effector lymphocytes in the control of hepatitis B virus (HBV) infection. However, limitations of model systems, such as low infection rates, restrict mechanistic studies of HBV-specific CD8+ T cells. Here, we established a novel immunological cell culture model based on HBV-infected HepG2hNTCP cells that endogenously processed viral antigens and presented them to HBV-specific CD8+ T cells. This induced cytolytic and noncytolytic CD8+ T-cell effector functions and reduction of viral loads. |
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| Beschreibung: |
Im Titel ist „hNTCP“ und "+"hochgestellt Gesehen am 04.04.2017 |
| Umfang: | 6 |
| ISSN: |
1098-5514
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| DOI: | 10.1128/JVI.00605-15 |