Eintrag weiter verarbeiten
Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts
Gespeichert in:
| Veröffentlicht in: | PLOS ONE Vol. 12.2017, 4, art. no. e0174860, insgesamt 16 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| Titel: | Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts/ Tatjana Perisic, Ziyang Zhang, Peter Foehr, Ursula Hopfner, Kathrin Klutz; Rainer H. Burgkart, Alexei Slobodianski, Moritz Goeldner; Hans-Günther Machens, Arndt F. Schilling |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
April 5, 2017
|
| Gesamtaufnahme: |
: PLOS ONE, Vol. 12.2017, 4, art. no. e0174860, insgesamt 16 Seiten
, volume:12 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| LEADER | 06211caa a2200997 4500 | ||
|---|---|---|---|
| 001 | 0-1048353044 | ||
| 003 | DE-627 | ||
| 005 | 20190806145329.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190205s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a urn:nbn:de:gbv:830-882.026123 |2 urn | |
| 024 | 7 | |a 10.15480/882.1993 |2 doi | |
| 024 | 7 | |a 10.1371%2Fjournal.pone.0174860 |2 doi | |
| 024 | 7 | |a 11420/1996 |2 hdl | |
| 035 | |a (DE-627)1048353044 | ||
| 035 | |a (DE-599)GBV1048353044 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 082 | 0 | |a 570: Biowissenschaften, Biologie | |
| 082 | 0 | 4 | |a 570 |
| 100 | 1 | |a Perisic, Tatjana |d 1976- |e VerfasserIn |0 (DE-588)1024389421 |0 (DE-627)719814650 |0 (DE-576)36840966X |4 aut | |
| 245 | 1 | 0 | |a Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts |c Tatjana Perisic, Ziyang Zhang, Peter Foehr, Ursula Hopfner, Kathrin Klutz; Rainer H. Burgkart, Alexei Slobodianski, Moritz Goeldner; Hans-Günther Machens, Arndt F. Schilling |
| 264 | 1 | |c April 5, 2017 | |
| 300 | |b Illustrationen, Diagramme | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Recent advances in gene delivery into cells allow improved therapeutic effects in gene therapy trials. To increase the bioavailability of applied cells, it is of great interest that transfected cells remain at the application site and systemic spread is minimized. In this study, we tested clinically used biodegradable poly(lactic acid-co-glycolic acid) (PLGA) scaffolds (Vicryl & Ethisorb) as transient carriers for genetically modified cells. To this aim, we used human fibroblasts and examined attachment and proliferation of untransfected cells on the scaffolds in vitro, as well as the mechanical properties of the scaffolds at four time points (1, 3, 6 and 9 days) of cultivation. Furthermore, the adherence of cells transfected with green fluorescent protein (GFP) and vascular endothelial growth factor (VEGF165) and also VEGF165 protein secretion were investigated. Our results show that human fibroblasts adhere on both types of PLGA scaffolds. However, proliferation and transgene expression capacity were higher on Ethisorb scaffolds most probably due to a different architecture of the scaffold. Additionally, cultivation of the cells on the scaffolds did not alter their biomechanical properties. The results of this investigation could be potentially exploited in therapeutic regiments with areal delivery of transiently transfected cells and may open the way for a variety of applications of cell-based gene therapy, tissue engineering and regenerative medicine. | ||
| 700 | 1 | |a Zhang, Ziyang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Foehr, Peter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Höpfner, Ursula |d 1949- |e VerfasserIn |0 (DE-588)1061698572 |0 (DE-627)805223193 |0 (DE-576)417815476 |4 aut | |
| 700 | 1 | |a Klutz, Kathrin |d 1975- |e VerfasserIn |0 (DE-588)1018167897 |0 (DE-627)680400826 |0 (DE-576)355165538 |4 aut | |
| 700 | 1 | |a Burgkart, Rainer |e VerfasserIn |0 (DE-588)1124417494 |0 (DE-627)878098518 |0 (DE-576)166428280 |4 aut | |
| 700 | 1 | |a Slobodianski, Alexei |e VerfasserIn |0 (DE-588)13225011X |0 (DE-627)519856740 |0 (DE-576)299031055 |4 aut | |
| 700 | 1 | |a Göldner, Moritz |e VerfasserIn |0 (DE-588)1176457195 |0 (DE-627)1047459280 |0 (DE-576)516645854 |4 aut | |
| 700 | 1 | |a Machens, Hans-Günther |d 1962- |e VerfasserIn |0 (DE-588)133584267 |0 (DE-627)548436657 |0 (DE-576)299950689 |4 aut | |
| 700 | 1 | |a Schilling, Arndt |d 1972- |e VerfasserIn |0 (DE-588)1027855563 |0 (DE-627)729923673 |0 (DE-576)375391894 |4 aut | |
| 710 | 2 | |a Technische Universität Hamburg |e Sonstige Körperschaft |0 (DE-588)1112763473 |0 (DE-627)866918418 |0 (DE-576)476770564 |4 oth | |
| 710 | 2 | |a Technische Universität Hamburg |b Institut für Technologie- und Innovationsmanagement |e Sonstige Körperschaft |0 (DE-588)1117238733 |0 (DE-627)871331497 |0 (DE-576)478877021 |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g Vol. 12.2017, 4, art. no. e0174860, insgesamt 16 Seiten |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2017 |g number:4 |
| 856 | 4 | 0 | |u http://nbn-resolving.de/urn:nbn:de:gbv:830-882.026123 |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.15480/882.1993 |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://hdl.handle.net/11420/1996 |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://doi.org/10.1371%2Fjournal.pone.0174860 |x Verlag |3 Volltext |
| 935 | |i DSpace | ||
| 936 | u | w | |d 12 |j 2017 |e 4 |y Vol. 12.2017, 4, art. no. e0174860, insgesamt 16 Seiten |
| 951 | |a AR | ||
| 856 | 4 | 0 | |u http://nbn-resolving.de/urn:nbn:de:gbv:830-882.026123 |9 LFER |
| 852 | |a LFER |z 2019-05-29T00:00:00Z | ||
| 970 | |c OD | ||
| 971 | |c EBOOK | ||
| 972 | |c EBOOK | ||
| 973 | |c Aufsatz | ||
| 935 | |a lfer | ||
| 900 | |a Machens, H.-G. | ||
| 900 | |a Burgkart, Rainer Hanns Hermann | ||
| 900 | |a Burgkart, Rainer H.H. | ||
| 900 | |a Höpfner-Tabori, Ursula | ||
| 900 | |a Tabori, Ursula Höpfner- | ||
| 900 | |a Goeldner, Moritz | ||
| 900 | |a Schilling, Arndt Friedrich | ||
| 900 | |a Schilling, Friedrich Arndt | ||
| 900 | |a Schilling, Arndt F. | ||
| 900 | |a Schilling, A. F. | ||
| 910 | |a Hamburg University of Technology | ||
| 910 | |a Technical University | ||
| 910 | |a Hamburg | ||
| 910 | |a Université de Technologie de Hambourg | ||
| 910 | |a TU Hamburg | ||
| 910 | |a TUHH | ||
| 910 | |a University of Technology | ||
| 910 | |a Technische Universität Hamburg-Harburg | ||
| 910 | |a Institut für Technologie- und Innovationsmanagement | ||
| 910 | |a Technische Universität Hamburg | ||
| 910 | |a Institute for Technology and Innovation Management | ||
| 910 | |a Institute of Technology and Innovation Management | ||
| 910 | |a Institut pour la gestion de la technologie et de l'innovation | ||
| 910 | |a Université de technologie de Hambourg | ||
| 910 | |a Institut W-7 | ||
| 910 | |a Studiendekanat Management-Wissenschaften und Technologie | ||
| 910 | |a TIM | ||
| 910 | |a TIM/TUHH | ||
| 910 | |a TIM TUHH | ||
| 951 | |b XA-DE | ||
| 980 | |a 1048353044 |b 0 |k 1048353044 |c lfer | ||
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Biodegradable+poly+%28lactic+acid-co-glycolic+acid%29+scaffolds+as+carriers+for+geneticallymodified+fibroblasts&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.creator=Perisic%2C+Tatjana&rft.pub=&rft.format=Journal&rft.language=English&rft.issn=1932-6203 |
|---|
| _version_ | 1785966758784401408 |
|---|---|
| access_facet | Electronic Resources |
| author | Perisic, Tatjana, Zhang, Ziyang, Foehr, Peter, Höpfner, Ursula, Klutz, Kathrin, Burgkart, Rainer, Slobodianski, Alexei, Göldner, Moritz, Machens, Hans-Günther, Schilling, Arndt |
| author_corporate | Technische Universität Hamburg, Technische Universität Hamburg, Technische Universität Hamburg Institut für Technologie- und Innovationsmanagement, Technische Universität Hamburg Institut für Technologie- und Innovationsmanagement |
| author_corporate_role | oth, Sonstige Körperschaft, oth, Sonstige Körperschaft |
| author_facet | Perisic, Tatjana, Zhang, Ziyang, Foehr, Peter, Höpfner, Ursula, Klutz, Kathrin, Burgkart, Rainer, Slobodianski, Alexei, Göldner, Moritz, Machens, Hans-Günther, Schilling, Arndt, Technische Universität Hamburg, Technische Universität Hamburg, Technische Universität Hamburg Institut für Technologie- und Innovationsmanagement, Technische Universität Hamburg Institut für Technologie- und Innovationsmanagement |
| author_role | aut, aut, aut, aut, aut, aut, aut, aut, aut, aut |
| author_sort | Perisic, Tatjana 1976- |
| author_variant | t p tp, z z zz, p f pf, u h uh, k k kk, r b rb, a s as, m g mg, h g m hgm, a s as |
| callnumber-sort | |
| collection | lfer |
| container_reference | Vol. 12.2017, 4, art. no. e0174860, insgesamt 16 Seiten |
| container_title | PLOS ONE |
| contents | Recent advances in gene delivery into cells allow improved therapeutic effects in gene therapy trials. To increase the bioavailability of applied cells, it is of great interest that transfected cells remain at the application site and systemic spread is minimized. In this study, we tested clinically used biodegradable poly(lactic acid-co-glycolic acid) (PLGA) scaffolds (Vicryl & Ethisorb) as transient carriers for genetically modified cells. To this aim, we used human fibroblasts and examined attachment and proliferation of untransfected cells on the scaffolds in vitro, as well as the mechanical properties of the scaffolds at four time points (1, 3, 6 and 9 days) of cultivation. Furthermore, the adherence of cells transfected with green fluorescent protein (GFP) and vascular endothelial growth factor (VEGF165) and also VEGF165 protein secretion were investigated. Our results show that human fibroblasts adhere on both types of PLGA scaffolds. However, proliferation and transgene expression capacity were higher on Ethisorb scaffolds most probably due to a different architecture of the scaffold. Additionally, cultivation of the cells on the scaffolds did not alter their biomechanical properties. The results of this investigation could be potentially exploited in therapeutic regiments with areal delivery of transiently transfected cells and may open the way for a variety of applications of cell-based gene therapy, tissue engineering and regenerative medicine. |
| ctrlnum | (DE-627)1048353044, (DE-599)GBV1048353044 |
| dewey-full | 570:BIOWISSENSCHAFTEN,BIOLOGIE, 570 |
| dewey-hundreds | 500 - Science |
| dewey-ones | 570 - Life sciences; biology |
| dewey-raw | 570: Biowissenschaften, Biologie, 570 |
| dewey-search | 570: Biowissenschaften, Biologie, 570 |
| dewey-sort | 3570 BIOWISSENSCHAFTEN BIOLOGIE |
| dewey-tens | 570 - Life sciences; biology |
| doi_str_mv | 10.15480/882.1993, 10.1371%2Fjournal.pone.0174860 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Medizin |
| fincclass_txtF_mv | science-biology |
| format | ElectronicBookComponentPart |
| format_access_txtF_mv | Article, E-Article |
| format_de105 | Ebook |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_del152 | Buch |
| format_detail_txtF_mv | text-online-monograph-child |
| format_dezi4 | e-Book |
| format_finc | Article, E-Article |
| format_legacy | ElectronicBookPart |
| format_strict_txtF_mv | E-Article |
| geogr_code | not assigned |
| geogr_code_person | Germany |
| hierarchy_parent_id | 0-523574592 |
| hierarchy_parent_title | PLOS ONE |
| hierarchy_sequence | Vol. 12.2017, 4, art. no. e0174860, insgesamt 16 Seiten |
| hierarchy_top_id | 0-523574592 |
| hierarchy_top_title | PLOS ONE |
| id | 0-1048353044 |
| illustrated | Not Illustrated |
| imprint | April 5, 2017 |
| imprint_str_mv | April 5, 2017 |
| institution | DE-D117, DE-105, LFER, DE-Ch1, DE-15, DE-14, DE-Zwi2 |
| is_hierarchy_id | 0-1048353044 |
| is_hierarchy_title | Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts |
| issn | 1932-6203 |
| kxp_id_str | 1048353044 |
| language | English |
| last_indexed | 2023-12-22T07:37:05.862Z |
| marc024a_ct_mv | urn:nbn:de:gbv:830-882.026123, 10.15480/882.1993, 10.1371%2Fjournal.pone.0174860, 11420/1996 |
| match_str | perisic2017biodegradablepolylacticacidcoglycolicacidscaffoldsascarriersforgeneticallymodifiedfibroblasts |
| mega_collection | Verbunddaten SWB, Lizenzfreie Online-Ressourcen |
| misc_de105 | EBOOK |
| multipart_link | 281331979 |
| multipart_part | (281331979)Vol. 12.2017, 4, art. no. e0174860, insgesamt 16 Seiten |
| names_id_str_mv | (DE-588)1024389421, (DE-627)719814650, (DE-576)36840966X, (DE-588)1061698572, (DE-627)805223193, (DE-576)417815476, (DE-588)1018167897, (DE-627)680400826, (DE-576)355165538, (DE-588)1124417494, (DE-627)878098518, (DE-576)166428280, (DE-588)13225011X, (DE-627)519856740, (DE-576)299031055, (DE-588)1176457195, (DE-627)1047459280, (DE-576)516645854, (DE-588)133584267, (DE-627)548436657, (DE-576)299950689, (DE-588)1027855563, (DE-627)729923673, (DE-576)375391894, (DE-588)1112763473, (DE-627)866918418, (DE-576)476770564, (DE-588)1117238733, (DE-627)871331497, (DE-576)478877021 |
| physical | Illustrationen, Diagramme |
| publishDate | April 5, 2017 |
| publishDateSort | 2017 |
| publishPlace | |
| publisher | |
| record_format | marcfinc |
| record_id | 1048353044 |
| recordtype | marcfinc |
| rvk_facet | No subject assigned |
| source_id | 0 |
| spelling | Perisic, Tatjana 1976- VerfasserIn (DE-588)1024389421 (DE-627)719814650 (DE-576)36840966X aut, Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts Tatjana Perisic, Ziyang Zhang, Peter Foehr, Ursula Hopfner, Kathrin Klutz; Rainer H. Burgkart, Alexei Slobodianski, Moritz Goeldner; Hans-Günther Machens, Arndt F. Schilling, April 5, 2017, Illustrationen, Diagramme, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Recent advances in gene delivery into cells allow improved therapeutic effects in gene therapy trials. To increase the bioavailability of applied cells, it is of great interest that transfected cells remain at the application site and systemic spread is minimized. In this study, we tested clinically used biodegradable poly(lactic acid-co-glycolic acid) (PLGA) scaffolds (Vicryl & Ethisorb) as transient carriers for genetically modified cells. To this aim, we used human fibroblasts and examined attachment and proliferation of untransfected cells on the scaffolds in vitro, as well as the mechanical properties of the scaffolds at four time points (1, 3, 6 and 9 days) of cultivation. Furthermore, the adherence of cells transfected with green fluorescent protein (GFP) and vascular endothelial growth factor (VEGF165) and also VEGF165 protein secretion were investigated. Our results show that human fibroblasts adhere on both types of PLGA scaffolds. However, proliferation and transgene expression capacity were higher on Ethisorb scaffolds most probably due to a different architecture of the scaffold. Additionally, cultivation of the cells on the scaffolds did not alter their biomechanical properties. The results of this investigation could be potentially exploited in therapeutic regiments with areal delivery of transiently transfected cells and may open the way for a variety of applications of cell-based gene therapy, tissue engineering and regenerative medicine., Zhang, Ziyang VerfasserIn aut, Foehr, Peter VerfasserIn aut, Höpfner, Ursula 1949- VerfasserIn (DE-588)1061698572 (DE-627)805223193 (DE-576)417815476 aut, Klutz, Kathrin 1975- VerfasserIn (DE-588)1018167897 (DE-627)680400826 (DE-576)355165538 aut, Burgkart, Rainer VerfasserIn (DE-588)1124417494 (DE-627)878098518 (DE-576)166428280 aut, Slobodianski, Alexei VerfasserIn (DE-588)13225011X (DE-627)519856740 (DE-576)299031055 aut, Göldner, Moritz VerfasserIn (DE-588)1176457195 (DE-627)1047459280 (DE-576)516645854 aut, Machens, Hans-Günther 1962- VerfasserIn (DE-588)133584267 (DE-627)548436657 (DE-576)299950689 aut, Schilling, Arndt 1972- VerfasserIn (DE-588)1027855563 (DE-627)729923673 (DE-576)375391894 aut, Technische Universität Hamburg Sonstige Körperschaft (DE-588)1112763473 (DE-627)866918418 (DE-576)476770564 oth, Technische Universität Hamburg Institut für Technologie- und Innovationsmanagement Sonstige Körperschaft (DE-588)1117238733 (DE-627)871331497 (DE-576)478877021 oth, Enthalten in PLOS ONE San Francisco, California, US : PLOS, 2006 Vol. 12.2017, 4, art. no. e0174860, insgesamt 16 Seiten Online-Ressource (DE-627)523574592 (DE-600)2267670-3 (DE-576)281331979 1932-6203 nnns, volume:12 year:2017 number:4, http://nbn-resolving.de/urn:nbn:de:gbv:830-882.026123 Resolving-System kostenfrei Volltext, https://doi.org/10.15480/882.1993 Resolving-System kostenfrei Volltext, http://hdl.handle.net/11420/1996 Resolving-System kostenfrei Volltext, https://doi.org/10.1371%2Fjournal.pone.0174860 Verlag Volltext, http://nbn-resolving.de/urn:nbn:de:gbv:830-882.026123 LFER, LFER 2019-05-29T00:00:00Z |
| spellingShingle | Perisic, Tatjana, Zhang, Ziyang, Foehr, Peter, Höpfner, Ursula, Klutz, Kathrin, Burgkart, Rainer, Slobodianski, Alexei, Göldner, Moritz, Machens, Hans-Günther, Schilling, Arndt, Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts, Recent advances in gene delivery into cells allow improved therapeutic effects in gene therapy trials. To increase the bioavailability of applied cells, it is of great interest that transfected cells remain at the application site and systemic spread is minimized. In this study, we tested clinically used biodegradable poly(lactic acid-co-glycolic acid) (PLGA) scaffolds (Vicryl & Ethisorb) as transient carriers for genetically modified cells. To this aim, we used human fibroblasts and examined attachment and proliferation of untransfected cells on the scaffolds in vitro, as well as the mechanical properties of the scaffolds at four time points (1, 3, 6 and 9 days) of cultivation. Furthermore, the adherence of cells transfected with green fluorescent protein (GFP) and vascular endothelial growth factor (VEGF165) and also VEGF165 protein secretion were investigated. Our results show that human fibroblasts adhere on both types of PLGA scaffolds. However, proliferation and transgene expression capacity were higher on Ethisorb scaffolds most probably due to a different architecture of the scaffold. Additionally, cultivation of the cells on the scaffolds did not alter their biomechanical properties. The results of this investigation could be potentially exploited in therapeutic regiments with areal delivery of transiently transfected cells and may open the way for a variety of applications of cell-based gene therapy, tissue engineering and regenerative medicine. |
| title | Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts |
| title_auth | Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts |
| title_full | Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts Tatjana Perisic, Ziyang Zhang, Peter Foehr, Ursula Hopfner, Kathrin Klutz; Rainer H. Burgkart, Alexei Slobodianski, Moritz Goeldner; Hans-Günther Machens, Arndt F. Schilling |
| title_fullStr | Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts Tatjana Perisic, Ziyang Zhang, Peter Foehr, Ursula Hopfner, Kathrin Klutz; Rainer H. Burgkart, Alexei Slobodianski, Moritz Goeldner; Hans-Günther Machens, Arndt F. Schilling |
| title_full_unstemmed | Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts Tatjana Perisic, Ziyang Zhang, Peter Foehr, Ursula Hopfner, Kathrin Klutz; Rainer H. Burgkart, Alexei Slobodianski, Moritz Goeldner; Hans-Günther Machens, Arndt F. Schilling |
| title_in_hierarchy | Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts / Tatjana Perisic, Ziyang Zhang, Peter Foehr, Ursula Hopfner, Kathrin Klutz; Rainer H. Burgkart, Alexei Slobodianski, Moritz Goeldner; Hans-Günther Machens, Arndt F. Schilling, |
| title_short | Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts |
| title_sort | biodegradable poly lactic acid co glycolic acid scaffolds as carriers for geneticallymodified fibroblasts |
| title_unstemmed | Biodegradable poly (lactic acid-co-glycolic acid) scaffolds as carriers for geneticallymodified fibroblasts |
| url | http://nbn-resolving.de/urn:nbn:de:gbv:830-882.026123, https://doi.org/10.15480/882.1993, http://hdl.handle.net/11420/1996, https://doi.org/10.1371%2Fjournal.pone.0174860 |
| urn | urn:nbn:de:gbv:830-882.026123 |