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Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma
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| Zeitschriftentitel: | Journal of Cancer Research Updates |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Journal of Cancer Research Updates, 1, 2012, 2, S. 181-188 |
| Format: | E-Article |
| Sprache: | Unbestimmt |
| veröffentlicht: |
Neoplasia Research
|
| author_facet |
Takuma Hayashi Akiko Horiuchi Kenji Sano Gal Gur Hiroyuki Aburatani Osamu Ishiko Nobuo Yaegashi Tanri Shiozawa Yae Kanai Dorit Zharhary Susumu Tonegawa Ikuo Konishi Takuma Hayashi Akiko Horiuchi Kenji Sano Gal Gur Hiroyuki Aburatani Osamu Ishiko Nobuo Yaegashi Tanri Shiozawa Yae Kanai Dorit Zharhary Susumu Tonegawa Ikuo Konishi |
|---|---|
| author |
Takuma Hayashi Akiko Horiuchi Kenji Sano Gal Gur Hiroyuki Aburatani Osamu Ishiko Nobuo Yaegashi Tanri Shiozawa Yae Kanai Dorit Zharhary Susumu Tonegawa Ikuo Konishi |
| spellingShingle |
Takuma Hayashi Akiko Horiuchi Kenji Sano Gal Gur Hiroyuki Aburatani Osamu Ishiko Nobuo Yaegashi Tanri Shiozawa Yae Kanai Dorit Zharhary Susumu Tonegawa Ikuo Konishi Journal of Cancer Research Updates Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| author_sort |
takuma hayashi |
| spelling |
Takuma Hayashi Akiko Horiuchi Kenji Sano Gal Gur Hiroyuki Aburatani Osamu Ishiko Nobuo Yaegashi Tanri Shiozawa Yae Kanai Dorit Zharhary Susumu Tonegawa Ikuo Konishi 1929-2279 Neoplasia Research http://dx.doi.org/10.6000/1929-2279.2012.01.02.4 <jats:p> Uterine leiomyosarcoma (Ut-LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of Ut-LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant Ut-LMS from other uterine mesenchymal tumors including leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with Ut-LMS, to establish a clinical treatment method. Proteasome subunit, low-molecular mass polypeptide(LMP2)/b1i-deficient mice spontaneously develop Ut-LMS, with a disease prevalence of ~40% by 14 months of age. Recent experiments with human and mouse uterine tissues revealed defective LMP2/b1i expression in human Ut-LMS that was traced to the interferon (IFN)-g pathway and a specific effect of Janus kinase (JAK)-1 somatic mutations on LMP2/b1i transcriptional activation. Furthermore, analysis of a human Ut-LMS cell line clarified the biological significance of LMP2/b1i in malignant myometrium transformation and the cell cycle, thus implicating LMP2/b1i as an anti-tumorigenic candidate. Therefore, defective-LMP2/b1i expression may be a risk factor for human Ut-LMS. LMP2/b1i is a potential diagnostic-biomarker for Ut-LMS, and may be a targeted-molecule for a new clinical therapeutic approach. </jats:p> Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma Journal of Cancer Research Updates |
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| title |
Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title_unstemmed |
Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title_full |
Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title_fullStr |
Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title_full_unstemmed |
Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title_short |
Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title_sort |
biological significance of the proteasome subunit lmp2/b1i as a tumor suppressor in human uterine leiomyosarcoma |
| url |
http://dx.doi.org/10.6000/1929-2279.2012.01.02.4 |
| publishDate |
2012 |
| physical |
181-188 |
| description |
<jats:p> Uterine leiomyosarcoma (Ut-LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of Ut-LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant Ut-LMS from other uterine mesenchymal tumors including leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with Ut-LMS, to establish a clinical treatment method. Proteasome subunit, low-molecular mass polypeptide(LMP2)/b1i-deficient mice spontaneously develop Ut-LMS, with a disease prevalence of ~40% by 14 months of age. Recent experiments with human and mouse uterine tissues revealed defective LMP2/b1i expression in human Ut-LMS that was traced to the interferon (IFN)-g pathway and a specific effect of Janus kinase (JAK)-1 somatic mutations on LMP2/b1i transcriptional activation. Furthermore, analysis of a human Ut-LMS cell line clarified the biological significance of LMP2/b1i in malignant myometrium transformation and the cell cycle, thus implicating LMP2/b1i as an anti-tumorigenic candidate. Therefore, defective-LMP2/b1i expression may be a risk factor for human Ut-LMS. LMP2/b1i is a potential diagnostic-biomarker for Ut-LMS, and may be a targeted-molecule for a new clinical therapeutic approach. </jats:p> |
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| author | Takuma Hayashi, Akiko Horiuchi, Kenji Sano, Gal Gur, Hiroyuki Aburatani, Osamu Ishiko, Nobuo Yaegashi, Tanri Shiozawa, Yae Kanai, Dorit Zharhary, Susumu Tonegawa, Ikuo Konishi |
| author_facet | Takuma Hayashi, Akiko Horiuchi, Kenji Sano, Gal Gur, Hiroyuki Aburatani, Osamu Ishiko, Nobuo Yaegashi, Tanri Shiozawa, Yae Kanai, Dorit Zharhary, Susumu Tonegawa, Ikuo Konishi, Takuma Hayashi, Akiko Horiuchi, Kenji Sano, Gal Gur, Hiroyuki Aburatani, Osamu Ishiko, Nobuo Yaegashi, Tanri Shiozawa, Yae Kanai, Dorit Zharhary, Susumu Tonegawa, Ikuo Konishi |
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| description | <jats:p> Uterine leiomyosarcoma (Ut-LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of Ut-LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant Ut-LMS from other uterine mesenchymal tumors including leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with Ut-LMS, to establish a clinical treatment method. Proteasome subunit, low-molecular mass polypeptide(LMP2)/b1i-deficient mice spontaneously develop Ut-LMS, with a disease prevalence of ~40% by 14 months of age. Recent experiments with human and mouse uterine tissues revealed defective LMP2/b1i expression in human Ut-LMS that was traced to the interferon (IFN)-g pathway and a specific effect of Janus kinase (JAK)-1 somatic mutations on LMP2/b1i transcriptional activation. Furthermore, analysis of a human Ut-LMS cell line clarified the biological significance of LMP2/b1i in malignant myometrium transformation and the cell cycle, thus implicating LMP2/b1i as an anti-tumorigenic candidate. Therefore, defective-LMP2/b1i expression may be a risk factor for human Ut-LMS. LMP2/b1i is a potential diagnostic-biomarker for Ut-LMS, and may be a targeted-molecule for a new clinical therapeutic approach. </jats:p> |
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| imprint | Neoplasia Research, 2012 |
| imprint_str_mv | Neoplasia Research, 2012 |
| institution | DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15 |
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| spelling | Takuma Hayashi Akiko Horiuchi Kenji Sano Gal Gur Hiroyuki Aburatani Osamu Ishiko Nobuo Yaegashi Tanri Shiozawa Yae Kanai Dorit Zharhary Susumu Tonegawa Ikuo Konishi 1929-2279 Neoplasia Research http://dx.doi.org/10.6000/1929-2279.2012.01.02.4 <jats:p> Uterine leiomyosarcoma (Ut-LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of Ut-LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker which distinguishes malignant Ut-LMS from other uterine mesenchymal tumors including leiomyoma (LMA) is yet to be established. Accordingly, it is necessary to analyze risk factors associated with Ut-LMS, to establish a clinical treatment method. Proteasome subunit, low-molecular mass polypeptide(LMP2)/b1i-deficient mice spontaneously develop Ut-LMS, with a disease prevalence of ~40% by 14 months of age. Recent experiments with human and mouse uterine tissues revealed defective LMP2/b1i expression in human Ut-LMS that was traced to the interferon (IFN)-g pathway and a specific effect of Janus kinase (JAK)-1 somatic mutations on LMP2/b1i transcriptional activation. Furthermore, analysis of a human Ut-LMS cell line clarified the biological significance of LMP2/b1i in malignant myometrium transformation and the cell cycle, thus implicating LMP2/b1i as an anti-tumorigenic candidate. Therefore, defective-LMP2/b1i expression may be a risk factor for human Ut-LMS. LMP2/b1i is a potential diagnostic-biomarker for Ut-LMS, and may be a targeted-molecule for a new clinical therapeutic approach. </jats:p> Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma Journal of Cancer Research Updates |
| spellingShingle | Takuma Hayashi, Akiko Horiuchi, Kenji Sano, Gal Gur, Hiroyuki Aburatani, Osamu Ishiko, Nobuo Yaegashi, Tanri Shiozawa, Yae Kanai, Dorit Zharhary, Susumu Tonegawa, Ikuo Konishi, Journal of Cancer Research Updates, Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title | Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title_full | Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title_fullStr | Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title_full_unstemmed | Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title_short | Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| title_sort | biological significance of the proteasome subunit lmp2/b1i as a tumor suppressor in human uterine leiomyosarcoma |
| title_unstemmed | Biological Significance of the Proteasome Subunit LMP2/b1i as a Tumor Suppressor in Human Uterine Leiomyosarcoma |
| url | http://dx.doi.org/10.6000/1929-2279.2012.01.02.4 |